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Theme 2 is aimed to define the direct contribution of long-lived self-renewing tissue-resident myeloid cells to HIV/SIV persistence during ART.

Theme 3 is aimed to further develop innovative CanCURE 1.0 therapeutic interventions that target the VR in both T-cells and MØ and translate new discoveries into therapeutic strategies.

The Animal Models Core develops animal models to test therapeutic approaches against persistent HIV viral reservoirs (VR) during antiretroviral therapy (ART). The Team benefits from models in simian immunodeficiency virus (SIV)-infected primates and humanized mice.

 
 
 
 

The Clinical Core provides access to clinical samples and offers strong management, analytical and biostatistical skills through CanCURE’s partnership with the CIHR Canadian HIV Trials Network (CTN).

 
 
 

Theme 1 is aimed to uncover mechanisms by which specific antigens and antigen presenting cells of myeloid lineage lead to the establishment and persistence of VR in Tm-cells.

 

Cores

 
 

©2019 CanCURE

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