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September 7, 2020

Recommendations for measuring HIV reservoir size in cure-directed clinical trials

Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont NBar KJ, Yu XG, Lichterfeld M, Alcami JHazuda D, Bushman F, Siliciano JD, Betts MR,Spivak AM, Planelles V, Hahn BH, Smith DM, Ho Y, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJKostman J, Mounzer K, Caskey M, Fox L, Frank I,Riley JL, Tebas P, Montaner LJ. Nature Med.

Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART

Gantner P, Pagliuzza A, Pardons M, Ramgopal M, Routy JP, Fromentin R and Chomont N. Nature Communications

August 14, 2020

May 15, 2020

Improving HIV Outgrowth by Optimizing Cell-Culture Conditions and Supplementing With all-trans Retinoic Acid.

Zhang Y, Planas D, Marchand LR, Massanella M, Chen H, Wacleche VS, Gosselin A, Goulet J-P, Filion M, Routy J-PChomont N and Ancuta P. Frontiers in Microbiology

Despite early antiretroviral therapy effector memory and follicular helper CD4 T cells are major reservoirs in visceral lymphoid tissues of SIV-infected macaques.

November 14th, 2019

Differential Dynamics of Regulatory T-Cell and Th17 Cell Balance in Mesenteric Lymph Nodes and Blood following Early Antiretroviral Initiation during Acute Simian Immunodeficiency Virus Infection.

September 12th, 2019

HIV Infection Stabilizes Macrophage-T Cell Interactions To Promote Cell-Cell HIV Spread.

Lopez PKoh WHHnatiuk RMurooka TT. J. Virology

August 28th, 2019

HIV diversity and genetic compartmentalization in blood and testes during suppressive antiretroviral therapy.

June 12th, 2019

Expression of MDM2 in Macrophages Promotes the Early Postentry Steps of HIV-1 Infection through Inhibition of p53.

March 21st, 2019

HIV-1 is rarely detected in blood and colon myeloid cells during viral-suppressive antiretroviral therapy.

March 11th, 2019

Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection.

February 27th, 2019

PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals.

February 18th, 2019

Host mRNA decay proteins influence HIV-1 replication and viral gene expression in primary monocyte-derived macrophages.

February 7th, 2019

Shringar Rao, Raquel Amorim, Meijuan Niu, Yann Breton, Michel J. Tremblay and Andrew J. Mouland. Retrovirology.

Genetic complexity in the replication-competent latent HIV reservoir increases with untreated infection duration in infected youth.

February 1st, 2019

Medical Assistance in Death as a Unique Opportunity to Advance HIV Cure Research.

January 31rst, 2019

HIV-1 Balances the Fitness Costs and Benefits of Disrupting the Host Cell Actin Cytoskeleton Early after Mucosal Transmission.

January 9th, 2019

HIV subtype and Nef-mediated immune evasion function correlate with viral reservoir size in early-treated individuals.

January 2nd, 2019

Implications of HIV-1 Nef for "Shock and Kill" Strategies to Eliminate Latent Viral Reservoirs.

November 30th, 2018

Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants

November 27th, 2018

HIV Cure Research: An example of successful advocacy by scientists for science 

November 3rd, 2018

Angel, JB. Clint Invest. Med. 

Phylogenetic approach to recover integration dates of latent HIV sequences within-host

September 5th, 2018

Bradley R. Jones, Natalie N. Kinloch, Joshua Horacsek, Bruce Ganase, Marianne Harris, P. Richard Harrigan, R. Brad Jones, Mark A. Brockman, Jeffrey B. Joy, Art F. Y. Poon, and Zabrina L. Brumme. PNAS

The RNA surveillance protein UPF1, UPF2 and SMG6 affects HIV-1 reactivation at post-transcriptional level.

June 28, 2018

Rao S, Amorin R, Niu M, Temzi A, Mouland A.  Retrovirology

Identification of Novel HIV-1 Latency-Reversing Agents from a Library of Marine Natural Products.

June 27, 2018

Richard K, Williams DE, de Silva ED, Brockman MA, Brummer ZL, Andersen RJ, Tietjen I. Viruses

cIAP1/2-TRAF2-SHP-1-Src-MyD88 Complex Regulates Lipopolysaccaride-Induced IL-27 Production through NF-kB Activation in Human Macrophages.

March 1, 2018

Busca A, Konarski Y, Gajanayaka N, O'Hara S, Angel J, Kozlowski M, Kumar A. J Immunology

Socio-economic status and time trends associated with early ART initiation following primary HIV infection in Montreal, Canada: 1996 to 2015.

Feb 6, 2018

Mehraj V, Cox J, Lebouché B, Costiniuk C, Cao W, Li T, Ponte R, Thomas R, Szabo J, Baril JG, Trottier B, Côté P, LeBlanc R, Bruneau J, Tremblay C, Routy JP; Montreal Primary HIV-Infection Study Group.  J Int AIDS Soc. 2018 Feb;21(2). doi: 10.1002/jia2.25034.

Inhibition of NF-κB-dependent HIV-1 replication by the marine natural product bengamide A.

April 15, 2018

Tietjen I, Williams DE, Read S, Kuang XT, Mwimanzi P, Wilhelm E, Markle T, Kinloch NN, Naphen CN, Tenney K, Mesplède T, Wainberg MA, Crews P, Bell B5, Andersen RJ, Brumme ZL, Brockman MA. Antiviral Res. 152:94-103. doi: 10.1016/j.antiviral.

ADAR1 and PKR, interferon stimulated genes with clashing effects on HIV-1 replication. 

March 26, 2018

Radetskyy R, Daher A, Gatignol A. Cytokine Growth Factor Rev.  pii: S1359-6101(18)30032-7. doi: 10.1016/j.cytogfr.2018.03.007. [Epub ahead of print]

Use of (1→3)-β-D-Glucan for diagnosis and management of invasive mycoses in HIV-infected patients.

May 31st, 2018

Farhour Z, Mehraj V, Chen J, Ramendra R, Lu H, Routy JP.  Mycoses. 2018 May 31;. [Epub ahead of print]

Contrasting effect of the latency-reversing agents bryostatin-1 and JQ1 on astrocyte-mediated neuroinflammation and brain neutrophil invasion.

Dec 11, 2017

The Biology of Monocytes and Dendritic Cells: Contribution to HIV Pathogenesis. 

Feb 6, 2018

Wacleche VS, Tremblay CL, Routy JPAncuta P. Viruses. 10(2). pii: E65. doi: 10.3390/v10020065.

Regulation of CD4 Receptor and HIV-1 Entry by MicroRNAs-221 and -222 during Differentiation of THP-1 Cells.

Dec 30, 2017

Lodge R, Gilmore JC, Ferreira Barbosa JA, Lombard-Vadnais F, Cohen ÉA. Viruses. 10(1). pii: E13. doi: 10.3390/v10010013.

Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling.

Jan 16, 2018

Wong RW, Lingwood CA, Ostrowski MA, Cabral T, Cochrane A.  Sci Rep. 8(1):850. doi: 10.1038/s41598-018-19298-x.

cIAP1/2-TRAF2-SHP-1-Src-MyD88 Complex Regulates Lipopolysaccharide-Induced IL-27 Production through NF-κB Activation in Human Macrophages. 

Jan 22, 2018

Busca A, Konarski Y, Gajanayaka N, O'Hara S, Angel J, Kozlowski M, Kumar A J Immunol.pii: ji1700199. doi: 10.4049/jimmunol.1700199. [Epub ahead of print]

Inducible HIV RNA transcription assays to measure HIV persistence: pros and cons of a compromise. 

Jan 17, 2018

Plantin J, Massanella M, Chomont N. Retrovirology.15(1):9. doi: 10.1186/s12977-017-0385-y.

The oncolytic virus, MG1, targets and eliminates latently HIV-1-infected cells: implications for an HIV cure.

Dec 8, 2017

Ranganath N, Sandstrom TS, Burke Schinkel SC, Côté SC, Angel JB. The Journal of Infectious Diseases.

Xenobiotic Nuclear Receptors Pregnane X Receptor and Constitutive Androstane Receptor Regulate Antiretroviral Drug Efflux Transporters at the Blood-Testis Barrier.

December, 2017

Managing Expectations of an HIV Cure: What Should We Expect?

Nov 22, 2017

Reinhard, RJ.  AIDS Res Hum Retroviruses. doi: 10.1089/AID.2017.0247. [Epub ahead of print]

HIV-1 NC-induced stress granule assembly and translation arrest are inhibited by the dsRNA binding protein Staufen1.

Nov 10, 2017

Rao S, Cinti A, Temzi A, Amorim R, You JC, Mouland AJ. HIV-1 NC-induced stress granule assembly and translation arrest are inhibited by the dsRNA binding protein Staufen1. RNA. 2017 Nov 10. pii: rna.064618.117. doi: 10.1261/rna.064618.117. [Epub ahead of print]

Very early antiretroviral therapy permits CD8 T cells to keep HIV reservoirs at bay.

Nov 5, 2017

Routy JP, Mehraj V. Ann Transl Med. 2017 Nov;5(21):434. doi: 10.21037/atm.2017.08.38.

The Interferon-induced Protein Kinase R: the base of a riboprotein scaffolding regulating the Human Immunodeficiency Virus.

Nov 2017

The Th17 Lineage: From Barrier Surfaces homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis.

Oct 19, 2017

Sue Waclech V, Landay A, Routy JP, Ancuta PViruses.  19;9(10). pii: E303. doi: 10.3390/v9100303.

Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain.

Oct 16, 2017

Characterization of myeloid cell populations in human testes collected after sex reassignment surgery.

Oct 11, 2017

Host MicroRNAs-221 and -222 Inhibit HIV-1 Entry in Macrophages by Targeting the CD4 Viral Receptor.

Oct 3, 2017

The evaluation of risk-benefit ratio for gut tissue sampling in HIV cure research.

Oct 1, 2017

The Croton megalobotrys Müll Arg. traditional medicine in HIV/AIDS management: Documentation of patient use, in vitro activation of latent HIV-1 provirus, and isolation of active phorbol esters.

Sept 29, 2017

Tietjen I, Ngwenya BN, Fotso G, Williams DE, Simonambango S, Ngadjui BT, Andersen RJ, Brockman MA, Brumme ZL,Andrae-Marobela K. J Ethnopharmacol. 29;211:267-277. doi: 10.1016/j.jep.2017.09.038. [Epub ahead of print]

Antiviral Activity of Bictegravir and Cabotegravir Against Integrase Inhibitor Resistant SIVmac239 and HIV-1.

Sept 18, 2017

Hassounah SA, Alikhani A, Oliveira M, Bharaj S, Ibanescu RI, Osman N, Xu HT, Brenner BG, Mesplède T, Wainberg MA. Antimicrob Agents Chemorther, 18 sept 2017.  doi: 10.1128/AAC.01695-17. [Epub ahead of print]

RNA flow cytometric FISH for investigations into HIV immunology, vaccination and cure strategies.

Sept 12, 2017

Baxter AE, Niessl J, Morou A, Kaufmann DE.  AIDS Res Ther 2017 DOI 10.1186/s12981-017-0171-x

Potential contribution of gut microbiota and systemic inflammation on HIV vaccine effectiveness and vaccine design.

Sept 12, 2017

Routy JP and Mehraj V. AIDS Res Ther 2017. DOI 10.1186/s12981-017-0164-9

Multiparametric characterization of rare HIV-infected cells using an RNA-flow FISH technique.

Sept 7, 2017

Pharmacologic HIV-1 Nef blockade promotes CD8 T cell–mediated elimination of latently HIV-1–infected cells in vitro.

Sept 7, 2017

HIV-1 selectively targets gut-homing CCR6+CD4+ T-cells via mTOR-dependent mechanisms.

Aug 3, 2017

Comprehensive cross-clade characterization of antibody-mediated recognition, complement-mediated lysis and cell-mediated cytotoxicity of HIV-1 envelope specific antibodies towards the eradication of the HIV-1 reservoir.

Jul 27, 2017

Mujib S, Liu J, Rahman AKMN, Schwartz JA, Bonner P, Yue FY, Ostrowski MAJ Virol. 27;91(16). pii: e00634-17. doi: 10.1128/JVI.00634-17. Print 2017 Aug 15.​

HIV-1 enhances mTORC1 activity and repositions lysosomes to the periphery by co-opting Rag GTPase.

Jul 14 2017

Global mapping of the macrophage-HIV-1 transcriptome reveals that productive infection induces remodeling of host cell DNA and chromatin.

Jul 12 2017

HIV-1 and HIV-Tat inhibit LPS-induced IL-27 production in human macrophages by distinct intracellular signaling pathway.

Jul 11, 2017

Impairment of the type I interferon response by HIV-1: Potential targets for HIV eradication.

Apr 24, 2017

Sandstrom TS, Ranganath N, Angel JB. Cytokine Growth Factor Rev. 37:1-16. doi: 10.1016/j.cytogfr.2017.04.004. Epub 2017 Apr 24.

Tim-3 is a marker of plasmacytoid dendritic cell dysfunction during HIV infection and is associated with the recruitment of IRF7 and p85 into lysosomes and with the submembrane displacement of TLR9.

Mar 6, 2017

Schwartz JA, Clayton KL, Mujib S, Zhang H, Rahman AK, Liu J, Yue FY, Benko E, Kovacs C, Ostrowski MA. J Immunol. 2017 Apr 15;198(8):3181-3194. doi: 10.4049/jimmunol.1601298. Epub 2017 Mar 6.

HIV-1 Vpu downmodulates ICAM-1 expression resulting in decreased killing of infected CD4+ T cells by NK cells.

Mar 29, 2017

Sugden SM, Pham TN, Cohen EA. Journal of virology, 91(8): e02442-16.

CD4 T follicular helper cells and HIV infection: Friends or enemies?

Feb 20, 2017

HIV persists in CCR6+CD4+ T-cells from colon and blood during antiretroviral therapy.

Jan 2, 2017

Gosselin A, Wiche Salinas TR, Planas D, Wacleche VS, Zhang Y, Fromentin R, Chomont N, Cohen EA, Shacklett B, Mehraj V, Ghali MP, Routy JPAncuta P. AIDS2017, 31(1): 35-48.​​

Ebola virus VP35 blocks stress granule assembly.

Dec 23, 2016

Le Sage V, Cinti A, McCarthy S, Amorim R, Rao S, Daino GL, Tramontano E, Branch DR, Mouland AJ. Virology. 2017 Feb;502:73-83. doi: 10.1016/j.virol.2016.12.012. Epub 2016 Dec 23.

HIV-1 latency-reversing agents prostratin and bryostatin-1 induce blood-brain barrier disruption/inflammation and modulate leukocyte adhesion/transmigration.

Dec 19, 2016

Dental C, Proust A, Ouellet M, Barat C, Tremblay MJ. J Immunol. Feb 1;198(3):1229-1241. doi: 10.4049/jimmunol.1600742. Epub 2016 Dec 19.

Immune tolerance properties of the testicular tissue as a viral sanctuary site in ART-treated HIV-infected adults.

Nov 28, 2016

Enhancing virion tethering by BST2 sensitizes productively and latently HIV-infected T cells to ADCC mediated by broadly neutralizing antibodies.

Nov 17, 2016

Pham TN, Lukhele S, Dallaire F, Perron G, Cohen EA. Scientific reports, 6: 37225.​

AMPK in Pathogens.

Nov 4, 2016

Differential control of BST2 restriction and plasmacytoid dendritic cell antiviral response by antagonists encoded by HIV-1 group M and O strains.

Oct 28, 2016

Bego MG, Cong L, Mack K, Kirchhoff F, Cohen EA. Journal of virology  2016, 90(22): 10236-10246.

Type I interferon responses are impaired in latently HIV infected cells.

Sept 9, 2016

Ranganath N, Sandstrom TS, Fadel S, Cote SC, Angel JB.  Retrovirology  2016, 13(1): 66.

Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals.

Aug 18, 2016

Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Charlebois R, Massanella M, Brassard N, Alsahafi N, Delgado G-G,Routy JP, Walker BD, Finzi A, Chomont NKaufmann DE.  Cell Host Microbe.  2016 Sep 14;20(3):368-380. doi: 10.1016/j.chom.2016.07.015. Epub 2016 Aug 18.

Kynurenine Reduces Memory CD4 T-Cell Survival by Interfering with Interleukin-2 Signaling Early during HIV-1 Infection.

Aug 12, 2016

Dagenais-Lussier X, Aounallah M, Mehraj V, El-Far M, Tremblay C, Sekaly RP, Routy JP, van Grevenynghe J; for the Montreal Primary Infection Study Group.  Journal of virology, 90(17): 7967-7979

Role and modulation of drug transporters in HIV-1 therapy.

May 13, 2016

Alam C, Whyte-Allman SK, Omeragic A, Bendayan R. Adv Drug Deliv Rev. Aug 1;103:121-43. doi: 10.1016/j.addr.2016.05.001. Epub 2016 May 13.

Publications

Antiretroviral drug transporters and metabolic enzymes in human testicular tissue: potential contribution to HIV-1 sanctuary site.

April 13, 2016

Huang Y, Hoque MT, Jenabian MA, Vyboh K, Whyte SK, Sheehan NL, Brassard P, Belanger M, Chomont N, Fletcher CV, Routy JPBendayan RJ Antimicrob Chemother. 2016 Jul;71(7):1954-65. doi: 10.1093/jac/dkw046. Epub 2016 Apr 13.

The plasma levels of soluble ST2 as a marker of gut mucosal damage in early HIV infection.

June 19, 2016

Mehraj V, Jenabian MA, Ponte R, Lebouche B, Costiniuk C, Thomas R, Baril JG, Leblanc R, Cox J, Tremblay C, Routy JP, for the Primary HIV Infection and the Long-Term Non-Progressors Study Groups. AIDS  2016, 30(10): 1617-1627.

Adapting the stress response: viral subversion of the mTOR signaling pathway.

May 24, 2016

Le Sage V, Cinti A, Amorim R, Mouland AJ. Viruses  2016, 8(6): 152

Indoleamine 2,3-dioxygenase-expressing aortic plasmacytoid dendritic cells protect against atherosclerosis by induction of regulatory T cells.

May 10, 2016

HIV-1-mediated BAFF secretion in macrophages does not require endosomal TLRs, type-I IFN, and Nef, but depends on the cellular phenotype status.

Mar 28, 2017

Gomez AM, Ouellet M, Deshiere A, Breton Y, Tremblay MJ. Journal of immunology  2016, 196(9): 3806-3817.  

Bacterial DNA protects monocytic cells against HIV-Vpr-induced mitochondrial membrane depolarization.

Mar 11, 2016

Saxena M, Busca A, Holcik M, Kumar A. Journal of immunology  2016, 196(9): 3754-3767.

Dendritic cell immunotherapy for HIV-1 infection using autologous HIV-1 RNA: a randomized, double-blind, placebo-controlled clinical trial.

May 1, 2016

Jacobson JM, Routy JP, Welles S, DeBenedette M, Tcherepanova I, Angel JB, Asmuth DM, Stein DK, Baril JG, McKellar M, Margolis DM, Trottier B, Wood K, Nicolette C. Journal of acquired immune deficiency syndromes  2016, 72(1): 31-38.

HIV-1 Gag blocks selenite-induced stress granule assembly by altering the mRNA cap-binding complex.

Mar 29, 2016

Cinti A, Le Sage V, Ghanem M, Mouland AJ. mBio  2016, 7(2):e00329-16.

Elevation and persistence of CD8 T-cells in HIV infection: the Achilles heel in the ART era.

Oct 3, 2017

Cao W, Mehraj V, Kaufmann DE, Li T, Routy JP.  Journal of the International AIDS Society  2016, 19(1): 20697.

Reversing gut damage in HIV infection: using non-human primate models to instruct clinical research.

Jan 26, 2016

Reversing gut damage in HIV infection: using non-human primate models to instruct clinical research.

Dec 2, 2015

HIV immunotherapy comes of age: implications for prevention, treatment and cure.

Dec 2, 2015

Routy JP, Mehraj V, Cao W. Expert review of clinical immunology  2016, 12(2): 91-94.

Early initiation rather than prolonged duration of antiretroviral therapy in HIV infection contributes to the normalization of CD8+ T-cell counts.

Sept 8, 2015

Cao W, Mehraj V, Trottier B, Baril JG, Leblanc R, Lebouche B, Cox J, Tremblay C, Lu W, Singer J, Li T, Routy JP, and the Montreal Primary HIV infection Study Group. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America  2016, 62(2): 250-257.

Characterization of in vitro generated human polarized macrophages.

Dec 21, 2015

Iqbal S, Kumar A. Journal of clinical & cellular immunology  2015, 6(6): 380.

 Early loss of splenic Tfh cells in SIV-infected rhesus macaques. 

Dec 7, 2015

 Differential evolution of a CXCR4-using HIV-1 strain in CCR5wt/wt and CCR5∆32/∆32 hosts revealed by longitudinal deep sequencing and phylogenetic reconstruction.

Dec 3, 2015

Characterization of the drug resistance profiles of integrase strand transfer inhibitors in simian immunodeficiency virus SIVmac239.

Sept 16, 2015

Attacking the supply lines: HIV-1 restricts alanine uptake to prevent T cell activation.

Nov 11, 2015

Sugden S, Cohen EA. Cell host & microbe  2015, 18(5): 514-517.

A robust and scalable TCR-based reporter cell assay to measure HIV-1 Nef-mediated T cell immune evasion.

Aug 28, 2015

HIV-1 recruits UPF1 but excludes UPF2 to promote nucleocytoplasmic export of the genomic RNA.

Oct 20, 2015

Challenges and opportunities for T-cell-mediated strategies to eliminate HIV reservoirs.

2 oct 2015

Brockman MA, Jones RB, Brumme ZL.  Frontiers in immunology  2015, 6:506. 

Overcoming the challenge of diagnosis of early HIV infection: a stepping stone to optimal patient management.

Sept 11, 2015

Routy JP, Cao W, Mehraj V. Expert review of anti-infective therapy, 13(10): 1189-1193.

Proteomic analysis of HIV-1 Gag interacting partners using proximity-dependent biotinylation.

Sept 11, 2015

Le Sage V, Cinti A, Valiente-Echeverria F, Mouland AJ.  Virology journal  2015, 12(1): 138.

 Immunosuppressive tryptophan catabolism and gut mucosal dysfunction following early HIV infection.

Jan 23, 2015

Jenabian MA, El-Far M, Vyboh K, Kema I, Costiniuk CT, Thomas R, Baril JG, LeBlanc R, Kanagaratham C, Radzioch D, Allam O, Ahmad A, Lebouche B, Tremblay C, Ancuta PRouty JP; for the Montreal Primary infection and Slow Progressor Study Groups. The Journal of infectious diseases  2015, 212:(3): 355-366.

Vpu exploits the cross-talk between BST2 and the ILT7 receptor to suppress anti-HIV-1 responses by plasmacytoid dendritic cells.

Jul 14, 2015

Bego MG, Côté E, Aschman N, Mercier J, Weissenhorn W, Cohen EA.  PLoS pathogens  2015, 11(7): e1005024.

CD4:CD8 ratio as a frontier marker for clinical outcome, immune dysfunction and viral reservoir size in virologically suppressed HIV-positive patients.

Jun 29, 2015

Lu W, Mehraj V, Vyboh K, Cao W, Li T, Routy JP. Journal of the International AIDS Society, 18: 20052.

Clinical relevance of kynurenine pathway in HIV/AIDS: An immune checkpoint at the crossroads of metabolism and inflammation.

May 6, 2015

Routy JP, Mehraj V, Vyboh K, Cao W, Kema I, Jenabian MA.  AIDS reviews, 17(2): 96-106.

Impaired Th17 polarization of phenotypically naive CD4+ T-cells during chronic HIV-1 infection and potential restoration with early ART.

Apr 30, 2015

HIV-1-triggered release of type I IFN by plasmacytoid dendritic cells induces BAFF production in monocytes.

Mar 1, 2015

Gomez AM, Ouellet M, Tremblay MJ. Journal of immunology, 194(5): 2300-2308.

Elevated expression of LAG-3, but not PD-1, is associated with impaired iNKT cytokine production during chronic HIV-1 infection and treatment.

Feb 13, 2015

PI3K/Akt regulates survival during differentiation of human macrophages by maintaining NF-kB-dependent expression of antiapoptotic Bcl-xL.

Sept 15, 2014

Busca A, Saxena M, Iqbal S, Angel J, Kumar A. Journal of leukocyte biology, 96(6): 1011-1022.

eEF2 and Ras-GAP SH3 domain-binding protein (G3BP1) modulate stress granule assembly during HIV-1 infection.

Sep 17, 2014

Effect of HIV-1 integrase resistance mutations when introduced into SIVmac239 on susceptibility to integrase strand transfer inhibitors.

Sept 1, 2014

Hassounah SA, Mesplede T, Quashie PK, Oliveira M, Sandstrom PA, Wainberg MA. Journal of virology2014, 88(17): 9683-9692.

A conserved target site in HIV-1 Gag RNA is accessible to inhibition by both an HDV ribozyme and a short hairpin RNA.

Jul 29, 2014

Scarborough RJ, Levesque MV, Boudrias-Dalle E, Chute IC, Daniels SM, Ouellette RJ, Perreault JP, Gatignol A.  Molecular therapy nucleic acids, 3: e178.

An evaluation of phylogenetic methods for reconstructing transmitted HIV variants using longitudinal clonal HIV sequence data.

Mar 19, 2014

McCloskey RM, Liang RH, Harrigan PR, Brumme ZLPoon AF.  Journal of virology, 88(11): 6181-6194.

Flt3L dependence helps define an uncharacterized subset of murine cutaneous dendritic cells.

Nov 28, 2013

Mollah SA, Dobrin JS, Feder RE, Tse SW, Matos IG, Cheong C, Steinman RM, Anandasabapathy N.  The Journal of investigative dermatology, 134(5): 1265-1275.

Role of P-glycoprotein in the distribution of the HIV protease inhibitor atazanavir in the brain and male genital tract.

Dec 30, 2013

Robillard KR, Chan GN, Zhang G, la Porte C, Cameron W, Bendayan R.  Antimicrobial agents and chemotherapy, 58(3): 1713-1722.

Control of dendritic cell migration, T cell-dependent immunity, and autoimmunity by protein tyrosine phosphatase PTPN12 expressed in dendritic cells.

Dec 23, 2013

Rhee I, Zhong MC, Reizis B, Cheong C, Veillette A. Molecular and cellular biology  2014, 34(5): 888-899.

From arrest to escape: HIV-1 Vpr cuts a deal.

Feb 12, 2014

Cohen EA. Cell host & microbe  2014, 15(2): 125-127

HIV Nef and Vpu protect HIV-infected CD4+ T cells from antibody-mediated cell lysis through down-modulation of CD4 and BST2.

Feb 6, 2014

Pham TN, Lukhele S, Hajjar F, Routy JPCohen EA. Retrovirology  2014, 11: 15

Deamination intensity profiling of human APOBEC3 protein activity along the near full-length genomes of HIV-1 and MoMLV by HyperHRM analysis.

Jan 4, 2014

Belanger K, Savoie M, Aydin H, Renner TM, Montazeri Z, Langlois MA. Virology  2014, 448: 168-175.

Transcriptional profiling reveals molecular signatures associated with HIV permissiveness in Th1Th17 cells and identifies peroxisome proliferator-activated receptor gamma as an intrinsic negative regulator of viral replication.

Dec 21, 2013

Bernier A, Cleret-Buhot A, Zhang Y, Goulet JP, Monteiro P, Gosselin A, DaFonseca S, Wacleche VS, Jenabian MA, Routy JP, Tremblay C, Ancuta P. Retrovirology  2013, 10: 160.

Efficient BST2 antagonism by Vpu is critical for early HIV-1 dissemination in humanized mice.

Nov 6, 2013

Dave VP, Hajjar F, Dieng MM, Haddad ECohen EA. Retrovirology  2013, 10: 128.

Selective recognition of viral promoters by host cell transcription complexes: challenges and opportunities to control latency.

Jul 1, 2013

Wilhelm E, Bell B. Current opinion in virology  2013, 3(4): 380-386

Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells.

Jun 14, 2013

Youngblood B, Noto A, Porichis F, Akondy RS, Ndhlovu ZM, Austin JW, Bordi R, Procopio FA, Miura T, Allen TM, Sidney J, Sette A, Walker BD, Ahmed R, Boss JM, Sekaly RP, Kaufmann DE. Journal of immunology  2013, 191(2): 540-544.

Interleukin-7 promotes HIV persistence during antiretroviral therapy.

Apr 15, 2013

Vandergeeten C, Fromentin R, DaFonseca S, Lawani MB, Sereti I, Lederman MM, Ramgopal M, Routy JP, Sekaly RP, Chomont N. Blood  2013, 121(21): 4321-4329.

Role of drug efflux and uptake transporters in atazanavir intestinal permeability and drug-drug interactions.

Dec 7, 2012

Kis O, Zastre JA, Hoque MT, Walmsley SL, Bendayan R. Pharmaceutical research  2013, 30(4): 1050-1064.

High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control.

Dec 11, 2012

Ndhlovu ZM, Chibnik LB, Proudfoot J, Vine S, McMullen A, Cesa K, Porichis F, Jones RB, Alvino DM, Hart MG, Stampouloglou E, Piechocka-Trocha A, Kadie C, Pereyra F, Heckerman D, De Jager PL, Walker BD, Kaufmann DE. Blood  2013, 121(5): 801-811.

Modulation of HIV reservoirs by host HLA: bridging the gap between vaccine and cure.

Aug 29, 2012

Brumme ZL, Chopera DR, Brockman MA. Current opinion in virology  2012, 2(5): 599-605.

Differential HIV-1 endocytosis and susceptibility to virus infection in human macrophages correlate with cell activation status.

Jul 11, 2012

Gobeil LA, Lodge R, Tremblay MJ. Journal of virology  2012, 86(19): 10399-10407.

Exon level transcriptomic profiling of HIV-1-infected CD4(+) T cells reveals virus-induced genes and host environment favorable for viral replication.

Aug 2, 2012

Imbeault M, Giguere K, Ouellet M, Tremblay MJ. PLoS pathogens  2012, 8(8): e1002861.

CTGC motifs within the HIV core promoter specify Tat-responsive pre-initiation complexes.

Jul 26, 2012

Wilhelm E, Doyle MC, Nzaramba I, Magdzinski A, Dumais N, Bell B.  Retrovirology, 9: 62.

Towards an HIV cure: a global scientific strategy.

Jul 20, 2012

The International AIDS Society Scientific Working Group on HIV Cure: Deeks SG, Autran B, Berkhout B, Benkirane M, Cairns S, Chomont N, Chun TW, Churchill M, Di Mascio M, Katlama C, Lafeuillade A, Landay A, Lederman M, Lewin SR, Maldarelli F, Margolis D, Markowitz M, Martinez-Picado J, Mullins JI, Mellors J, Moreno S, O'Doherty U, Palmer S, Penicaud MC, Peterlin M, Poli G, Routy JP, Rouzioux C, Silvestri G, Stevenson M, Telenti A, Van Lint C, Verdin E, Woolfrey A, Zaia J, Barre-Sinoussi F. Nature reviews immunology, 12(8): 607-614.