Publications

Targeting Th17cells in HIV-1 remission / cure interventions
July 2022
Fert A, Marchand LR, Wiche Salinas T R, Ancuta P

 


Bryostatin-1 Decreases HIV-1 Infection and Viral Production in
Human Primary Macrophages.

February 2022
Hany L, Turmel M, Barat COuellet M, Tremblay M J




T cell migration potentiates HIV infection by enhancing viral fusion and integration. 
February 2022
Lopex P, Ajibola O, Pagiluzza A, Zayats R, Hon Koh W, Herschhorn A, Chomont N, Murooka T





Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth
 

November 2021

Salinas TRW, Zhang Y, Sarnello D, Zhyvoloup A, Raymond Marchanda L, Planas D, Lodha M, Chatterjee D, Karwacz K, Oxenford S, Routy JP, Madsen H, Ancuta P, and Fassati A. PNAS

LILAC pilot study: Effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy

March 2021

Planas DPagliuzza APonte RFert AMarchand L.R, Massanella M, Gosselin A, Mehraj VDupuy F.P, Isnard S, Goulet J-P, Lesage S, , Ghali M.P, Angel JChomont NRouty J-PAncuta P. EBioMedicine.

Beyond the Absence of CD4 T-Cell Count: A Novel Genetic CD4 T-Cell Deficiency Disorder With a Contingency Plan

Routy J-PIsnard S. J Infect Dis.

February 24 2021


Differences in HIV burden in the inflamed and non-inflamed colon from a person living with HIV and ulcerative colitis

Peng X, Isnard S, Lin J, Fombuena B, Bessissow T, Chomont NRouty J-P. J Virus Erad.

February 15 2021

Peculiar Phenotypic and Cytotoxic Features of Pulmonary Mucosal CD8 T Cells in People Living with HIV Receiving Long-Term Antiretroviral Therapy

December 14 2020

Early Antiretroviral Therapy Prevents Viral Infection of Monocytes and Inflammation in Simian Immunodeficiency Virus-Infected Rhesus Macaques

October 27 2020

Pharmacological Inhibition of PPARy Boosts HIV Reactivation and Th17 Effector Functions, While Preventing Progeny Virion Release and de novo Infection

September 30 2020

Interleukin-1β Triggers p53-Mediated Downmodulation of CCR5 and HIV-1 Entry in Macrophages through MicroRNAs 103 and 107

September 29 2020

HIV enters deep sleep in people who naturally control the virus

September 2020

Distinct viral reservoirs in individuals with spontaneous control of HIV-1

September 2020

Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont NBar KJ, Yu XG, Lichterfeld M, Alcami JHazuda D, Bushman F, Siliciano JD, Betts MR,Spivak AM, Planelles V, Hahn BH, Smith DM, Ho Y, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJKostman J, Mounzer K, Caskey M, Fox L, Frank I,Riley JL, Tebas P, Montaner LJ. Nature Med.

Recommendations for measuring HIV reservoir size in cure-directed clinical trials

September 7, 2020

Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont NBar KJ, Yu XG, Lichterfeld M, Alcami JHazuda D, Bushman F, Siliciano JD, Betts MR,Spivak AM, Planelles V, Hahn BH, Smith DM, Ho Y, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJKostman J, Mounzer K, Caskey M, Fox L, Frank I,Riley JL, Tebas P, Montaner LJ. Nature Med.

HIV-Captured DCs Regulate T Cell Migration and Cell-Cell Contact Dynamics to Enhance Viral Spread.

August 21, 2020

Hon Koh W, Lopez P, Ajibola O, Parvarchian R, Mohammad U, Hnatiuk R, Kindrachuk J, Murooka TT. iScienc.

Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART

August 14, 2020

Gantner P, Pagliuzza A, Pardons M, Ramgopal M, Routy JP, Fromentin R and Chomont N. Nature Communications

Improving HIV Outgrowth by Optimizing Cell-Culture Conditions and Supplementing With all-trans Retinoic Acid.

May 15, 2020

Zhang Y, Planas D, Marchand LR, Massanella M, Chen H, Wacleche VS, Gosselin A, Goulet J-P, Filion M, Routy J-PChomont N and Ancuta P. Frontiers in Microbiology

The Bacterium Akkermansia muciniphila: A Sentinel for Gut Permeability and Its Relevance to HIV-Related Inflammation.

April 9, 2020

Ouyang J, Lin J, Isnard S, Fombuena B, Peng X, Marette A, Routy B, Messaoudene M, Chen Y, Routy J-P. Frontiers in Immunology. 

The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies.

April 8, 2020

Cohn LB, Chomont N, Deeks SG. Cell Host Microbe. 

Metformin effect on gut microbiota: insights for HIV-related inflammation

Ouyang J, Isnard S, Lin J, Fombuena B, Marette A, Routy B, Chen Y, Routy JP. AIDS research and Therapy. 

March 10, 2020

January 1, 2020

Despite early antiretroviral therapy effector memory and follicular helper CD4 T cells are major reservoirs in visceral lymphoid tissues of SIV-infected macaques.

November 14th, 2019

Differential Dynamics of Regulatory T-Cell and Th17 Cell Balance in Mesenteric Lymph Nodes and Blood following Early Antiretroviral Initiation during Acute Simian Immunodeficiency Virus Infection.

September 12th, 2019

HIV Infection Stabilizes Macrophage-T Cell Interactions To Promote Cell-Cell HIV Spread.

Lopez PKoh WHHnatiuk RMurooka TT. J. Virology

August 28th, 2019

HIV diversity and genetic compartmentalization in blood and testes during suppressive antiretroviral therapy.

June 12th, 2019

Expression of MDM2 in Macrophages Promotes the Early Postentry Steps of HIV-1 Infection through Inhibition of p53.

March 21st, 2019

HIV-1 is rarely detected in blood and colon myeloid cells during viral-suppressive antiretroviral therapy.

March 11th, 2019

Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection.

February 27th, 2019

PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals.

February 18th, 2019

Host mRNA decay proteins influence HIV-1 replication and viral gene expression in primary monocyte-derived macrophages.

February 7th, 2019

Shringar Rao, Raquel Amorim, Meijuan Niu, Yann Breton, Michel J. Tremblay and Andrew J. Mouland. Retrovirology.

Genetic complexity in the replication-competent latent HIV reservoir increases with untreated infection duration in infected youth.

February 1st, 2019

Medical Assistance in Death as a Unique Opportunity to Advance HIV Cure Research.

January 31rst, 2019

HIV-1 Balances the Fitness Costs and Benefits of Disrupting the Host Cell Actin Cytoskeleton Early after Mucosal Transmission.

January 9th, 2019

HIV subtype and Nef-mediated immune evasion function correlate with viral reservoir size in early-treated individuals.

January 2nd, 2019

Implications of HIV-1 Nef for "Shock and Kill" Strategies to Eliminate Latent Viral Reservoirs.

November 30th, 2018

Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants

November 27th, 2018

HIV Cure Research: An example of successful advocacy by scientists for science 

November 3rd, 2018

Angel, JB. Clint Invest. Med. 

Phylogenetic approach to recover integration dates of latent HIV sequences within-host

September 5th, 2018

Bradley R. Jones, Natalie N. Kinloch, Joshua Horacsek, Bruce Ganase, Marianne Harris, P. Richard Harrigan, R. Brad Jones, Mark A. Brockman, Jeffrey B. Joy, Art F. Y. Poon, and Zabrina L. Brumme. PNAS

The RNA surveillance protein UPF1, UPF2 and SMG6 affects HIV-1 reactivation at post-transcriptional level.

June 28, 2018

Rao S, Amorin R, Niu M, Temzi A, Mouland A.  Retrovirology

Identification of Novel HIV-1 Latency-Reversing Agents from a Library of Marine Natural Products.

June 27, 2018

Richard K, Williams DE, de Silva ED, Brockman MA, Brummer ZL, Andersen RJ, Tietjen I. Viruses

cIAP1/2-TRAF2-SHP-1-Src-MyD88 Complex Regulates Lipopolysaccaride-Induced IL-27 Production through NF-kB Activation in Human Macrophages.

March 1, 2018

Busca A, Konarski Y, Gajanayaka N, O'Hara S, Angel J, Kozlowski M, Kumar A. J Immunology

Socio-economic status and time trends associated with early ART initiation following primary HIV infection in Montreal, Canada: 1996 to 2015.

Feb 6, 2018

Mehraj V, Cox J, Lebouché B, Costiniuk C, Cao W, Li T, Ponte R, Thomas R, Szabo J, Baril JG, Trottier B, Côté P, LeBlanc R, Bruneau J, Tremblay C, Routy JP; Montreal Primary HIV-Infection Study Group.  J Int AIDS Soc. 2018 Feb;21(2). doi: 10.1002/jia2.25034.

Inhibition of NF-κB-dependent HIV-1 replication by the marine natural product bengamide A.

April 15, 2018

Tietjen I, Williams DE, Read S, Kuang XT, Mwimanzi P, Wilhelm E, Markle T, Kinloch NN, Naphen CN, Tenney K, Mesplède T, Wainberg MA, Crews P, Bell B5, Andersen RJ, Brumme ZL, Brockman MA. Antiviral Res. 152:94-103. doi: 10.1016/j.antiviral.

ADAR1 and PKR, interferon stimulated genes with clashing effects on HIV-1 replication. 

March 26, 2018

Radetskyy R, Daher A, Gatignol A. Cytokine Growth Factor Rev.  pii: S1359-6101(18)30032-7. doi: 10.1016/j.cytogfr.2018.03.007. [Epub ahead of print]

Use of (1→3)-β-D-Glucan for diagnosis and management of invasive mycoses in HIV-infected patients.

May 31st, 2018

Farhour Z, Mehraj V, Chen J, Ramendra R, Lu H, Routy JP.  Mycoses. 2018 May 31;. [Epub ahead of print]

Contrasting effect of the latency-reversing agents bryostatin-1 and JQ1 on astrocyte-mediated neuroinflammation and brain neutrophil invasion.

Dec 11, 2017

The Biology of Monocytes and Dendritic Cells: Contribution to HIV Pathogenesis. 

Feb 6, 2018

Wacleche VS, Tremblay CL, Routy JPAncuta P. Viruses. 10(2). pii: E65. doi: 10.3390/v10020065.

Regulation of CD4 Receptor and HIV-1 Entry by MicroRNAs-221 and -222 during Differentiation of THP-1 Cells.

Dec 30, 2017

Lodge R, Gilmore JC, Ferreira Barbosa JA, Lombard-Vadnais F, Cohen ÉA. Viruses. 10(1). pii: E13. doi: 10.3390/v10010013.

Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling.

Jan 16, 2018

Wong RW, Lingwood CA, Ostrowski MA, Cabral T, Cochrane A.  Sci Rep. 8(1):850. doi: 10.1038/s41598-018-19298-x.

cIAP1/2-TRAF2-SHP-1-Src-MyD88 Complex Regulates Lipopolysaccharide-Induced IL-27 Production through NF-κB Activation in Human Macrophages. 

Jan 22, 2018

Busca A, Konarski Y, Gajanayaka N, O'Hara S, Angel J, Kozlowski M, Kumar A J Immunol.pii: ji1700199. doi: 10.4049/jimmunol.1700199. [Epub ahead of print]

Inducible HIV RNA transcription assays to measure HIV persistence: pros and cons of a compromise. 

Jan 17, 2018

Plantin J, Massanella M, Chomont N. Retrovirology.15(1):9. doi: 10.1186/s12977-017-0385-y.

The oncolytic virus, MG1, targets and eliminates latently HIV-1-infected cells: implications for an HIV cure.

Dec 8, 2017

Ranganath N, Sandstrom TS, Burke Schinkel SC, Côté SC, Angel JB. The Journal of Infectious Diseases.

Xenobiotic Nuclear Receptors Pregnane X Receptor and Constitutive Androstane Receptor Regulate Antiretroviral Drug Efflux Transporters at the Blood-Testis Barrier.

December, 2017

Managing Expectations of an HIV Cure: What Should We Expect?

Nov 22, 2017

Reinhard, RJ.  AIDS Res Hum Retroviruses. doi: 10.1089/AID.2017.0247. [Epub ahead of print]

HIV-1 NC-induced stress granule assembly and translation arrest are inhibited by the dsRNA binding protein Staufen1.

Nov 10, 2017

Rao S, Cinti A, Temzi A, Amorim R, You JC, Mouland AJ. HIV-1 NC-induced stress granule assembly and translation arrest are inhibited by the dsRNA binding protein Staufen1. RNA. 2017 Nov 10. pii: rna.064618.117. doi: 10.1261/rna.064618.117. [Epub ahead of print]

Very early antiretroviral therapy permits CD8 T cells to keep HIV reservoirs at bay.

Nov 5, 2017

Routy JP, Mehraj V. Ann Transl Med. 2017 Nov;5(21):434. doi: 10.21037/atm.2017.08.38.

The Interferon-induced Protein Kinase R: the base of a riboprotein scaffolding regulating the Human Immunodeficiency Virus.

Nov 2017

The Th17 Lineage: From Barrier Surfaces homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis.

Oct 19, 2017

Sue Waclech V, Landay A, Routy JP, Ancuta PViruses.  19;9(10). pii: E303. doi: 10.3390/v9100303.

Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain.

Oct 16, 2017

Characterization of myeloid cell populations in human testes collected after sex reassignment surgery.

Oct 11, 2017

Host MicroRNAs-221 and -222 Inhibit HIV-1 Entry in Macrophages by Targeting the CD4 Viral Receptor.

Oct 3, 2017

The evaluation of risk-benefit ratio for gut tissue sampling in HIV cure research.

Oct 1, 2017

The Croton megalobotrys Müll Arg. traditional medicine in HIV/AIDS management: Documentation of patient use, in vitro activation of latent HIV-1 provirus, and isolation of active phorbol esters.

Sept 29, 2017

Tietjen I, Ngwenya BN, Fotso G, Williams DE, Simonambango S, Ngadjui BT, Andersen RJ, Brockman MA, Brumme ZL,Andrae-Marobela K. J Ethnopharmacol. 29;211:267-277. doi: 10.1016/j.jep.2017.09.038. [Epub ahead of print]

Antiviral Activity of Bictegravir and Cabotegravir Against Integrase Inhibitor Resistant SIVmac239 and HIV-1.

Sept 18, 2017

Hassounah SA, Alikhani A, Oliveira M, Bharaj S, Ibanescu RI, Osman N, Xu HT, Brenner BG, Mesplède T, Wainberg MA. Antimicrob Agents Chemorther, 18 sept 2017.  doi: 10.1128/AAC.01695-17. [Epub ahead of print]

RNA flow cytometric FISH for investigations into HIV immunology, vaccination and cure strategies.

Sept 12, 2017

Baxter AE, Niessl J, Morou A, Kaufmann DE.  AIDS Res Ther 2017 DOI 10.1186/s12981-017-0171-x

Potential contribution of gut microbiota and systemic inflammation on HIV vaccine effectiveness and vaccine design.

Sept 12, 2017

Routy JP and Mehraj V. AIDS Res Ther 2017. DOI 10.1186/s12981-017-0164-9

Multiparametric characterization of rare HIV-infected cells using an RNA-flow FISH technique.

Sept 7, 2017

Pharmacologic HIV-1 Nef blockade promotes CD8 T cell–mediated elimination of latently HIV-1–infected cells in vitro.

Sept 7, 2017

HIV-1 selectively targets gut-homing CCR6+CD4+ T-cells via mTOR-dependent mechanisms.

Aug 3, 2017

Comprehensive cross-clade characterization of antibody-mediated recognition, complement-mediated lysis and cell-mediated cytotoxicity of HIV-1 envelope specific antibodies towards the eradication of the HIV-1 reservoir.

Jul 27, 2017

Mujib S, Liu J, Rahman AKMN, Schwartz JA, Bonner P, Yue FY, Ostrowski MAJ Virol. 27;91(16). pii: e00634-17. doi: 10.1128/JVI.00634-17. Print 2017 Aug 15.​

HIV-1 enhances mTORC1 activity and repositions lysosomes to the periphery by co-opting Rag GTPase.

Jul 14 2017

Global mapping of the macrophage-HIV-1 transcriptome reveals that productive infection induces remodeling of host cell DNA and chromatin.

Jul 12 2017

HIV-1 and HIV-Tat inhibit LPS-induced IL-27 production in human macrophages by distinct intracellular signaling pathway.

Jul 11, 2017

Impairment of the type I interferon response by HIV-1: Potential targets for HIV eradication.

Apr 24, 2017

Sandstrom TS, Ranganath N, Angel JB. Cytokine Growth Factor Rev. 37:1-16. doi: 10.1016/j.cytogfr.2017.04.004. Epub 2017 Apr 24.

Tim-3 is a marker of plasmacytoid dendritic cell dysfunction during HIV infection and is associated with the recruitment of IRF7 and p85 into lysosomes and with the submembrane displacement of TLR9.

Mar 6, 2017

Schwartz JA, Clayton KL, Mujib S, Zhang H, Rahman AK, Liu J, Yue FY, Benko E, Kovacs C, Ostrowski MA. J Immunol. 2017 Apr 15;198(8):3181-3194. doi: 10.4049/jimmunol.1601298. Epub 2017 Mar 6.

HIV-1 Vpu downmodulates ICAM-1 expression resulting in decreased killing of infected CD4+ T cells by NK cells.

Mar 29, 2017

Sugden SM, Pham TN, Cohen EA. Journal of virology, 91(8): e02442-16.

CD4 T follicular helper cells and HIV infection: Friends or enemies?

Feb 20, 2017

HIV persists in CCR6+CD4+ T-cells from colon and blood during antiretroviral therapy.

Jan 2, 2017

Gosselin A, Wiche Salinas TR, Planas D, Wacleche VS, Zhang Y, Fromentin R, Chomont N, Cohen EA, Shacklett B, Mehraj V, Ghali MP, Routy JPAncuta P. AIDS2017, 31(1): 35-48.​​

Ebola virus VP35 blocks stress granule assembly.

Dec 23, 2016

Le Sage V, Cinti A, McCarthy S, Amorim R, Rao S, Daino GL, Tramontano E, Branch DR, Mouland AJ. Virology. 2017 Feb;502:73-83. doi: 10.1016/j.virol.2016.12.012. Epub 2016 Dec 23.

HIV-1 latency-reversing agents prostratin and bryostatin-1 induce blood-brain barrier disruption/inflammation and modulate leukocyte adhesion/transmigration.

Dec 19, 2016

Dental C, Proust A, Ouellet M, Barat C, Tremblay MJ. J Immunol. Feb 1;198(3):1229-1241. doi: 10.4049/jimmunol.1600742. Epub 2016 Dec 19.

Immune tolerance properties of the testicular tissue as a viral sanctuary site in ART-treated HIV-infected adults.

Nov 28, 2016

Enhancing virion tethering by BST2 sensitizes productively and latently HIV-infected T cells to ADCC mediated by broadly neutralizing antibodies.

Nov 17, 2016

Pham TN, Lukhele S, Dallaire F, Perron G, Cohen EA. Scientific reports, 6: 37225.​

AMPK in Pathogens.

Nov 4, 2016

Differential control of BST2 restriction and plasmacytoid dendritic cell antiviral response by antagonists encoded by HIV-1 group M and O strains.

Oct 28, 2016

Bego MG, Cong L, Mack K, Kirchhoff F, Cohen EA. Journal of virology  2016, 90(22): 10236-10246.

Type I interferon responses are impaired in latently HIV infected cells.

Sept 9, 2016

Ranganath N, Sandstrom TS, Fadel S, Cote SC, Angel JB.  Retrovirology  2016, 13(1): 66.

Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals.

Aug 18, 2016

Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Charlebois R, Massanella M, Brassard N, Alsahafi N, Delgado G-G,Routy JP, Walker BD, Finzi A, Chomont NKaufmann DE.  Cell Host Microbe.  2016 Sep 14;20(3):368-380. doi: 10.1016/j.chom.2016.07.015. Epub 2016 Aug 18.

Kynurenine Reduces Memory CD4 T-Cell Survival by Interfering with Interleukin-2 Signaling Early during HIV-1 Infection.

Aug 12, 2016

Dagenais-Lussier X, Aounallah M, Mehraj V, El-Far M, Tremblay C, Sekaly RP, Routy JP, van Grevenynghe J; for the Montreal Primary Infection Study Group.  Journal of virology, 90(17): 7967-7979

Role and modulation of drug transporters in HIV-1 therapy.

May 13, 2016

Alam C, Whyte-Allman SK, Omeragic A, Bendayan R. Adv Drug Deliv Rev. Aug 1;103:121-43. doi: 10.1016/j.addr.2016.05.001. Epub 2016 May 13.

Bryostatin-1 Decreases HIV-1 Infection and Viral Production in
Human Primary Macrophages.

February 2022

T cell migration potentiates HIV infection by enhancing viral fusion and integration. 
February 2022
Lopex P, Ajibola O, Pagiluzza A, Zayats R, Hon Koh W,Herschhorn A, Chomont N, Murooka T




Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth

November 2021

Salinas TRW, Zhang Y, Sarnello D, Zhyvoloup A, Raymond Marchanda L, Planas D, Lodha M, Chatterjee D, Karwacz K, Oxenford S, Routy JP, Madsen H, Ancuta P, and Fassati A. PNAS

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LILAC pilot study: Effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy

March 2021

Planas DPagliuzza APonte RFert AMarchand L.R, Massanella M, Gosselin A, Mehraj VDupuy F.P, Isnard S, Goulet J-P, Lesage S, , Ghali M.P, Angel JChomont NRouty J-PAncuta P. EBioMedicine.

Beyond the Absence of CD4 T-Cell Count: A Novel Genetic CD4 T-Cell Deficiency Disorder With a Contingency Plan

Routy J-PIsnard S. J Infect Dis.

February 24 2021

Differences in HIV burden in the inflamed and non-inflamed colon from a person living with HIV and ulcerative colitis

Peng X, Isnard S, Lin J, Fombuena B, Bessissow T, Chomont NRouty J-P. J Virus Erad.

February 15 2021

Peculiar Phenotypic and Cytotoxic Features of Pulmonary Mucosal CD8 T Cells in People Living with HIV Receiving Long-Term Antiretroviral Therapy

December 14 2020

Early Antiretroviral Therapy Prevents Viral Infection of Monocytes and Inflammation in Simian Immunodeficiency Virus-Infected Rhesus Macaques

October 27 2020

Pharmacological Inhibition of PPARy Boosts HIV Reactivation and Th17 Effector Functions, While Preventing Progeny Virion Release and de novo Infection

September 30 2020

Interleukin-1β Triggers p53-Mediated Downmodulation of CCR5 and HIV-1 Entry in Macrophages through MicroRNAs 103 and 107

September 29 2020

HIV enters deep sleep in people who naturally control the virus

September 2020

Distinct viral reservoirs in individuals with spontaneous control of HIV-1

September 2020

Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont NBar KJ, Yu XG, Lichterfeld M, Alcami JHazuda D, Bushman F, Siliciano JD, Betts MR,Spivak AM, Planelles V, Hahn BH, Smith DM, Ho Y, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJKostman J, Mounzer K, Caskey M, Fox L, Frank I,Riley JL, Tebas P, Montaner LJ. Nature Med.

Recommendations for measuring HIV reservoir size in cure-directed clinical trials

September 7, 2020

Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont NBar KJ, Yu XG, Lichterfeld M, Alcami JHazuda D, Bushman F, Siliciano JD, Betts MR,Spivak AM, Planelles V, Hahn BH, Smith DM, Ho Y, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJKostman J, Mounzer K, Caskey M, Fox L, Frank I,Riley JL, Tebas P, Montaner LJ. Nature Med.

HIV-Captured DCs Regulate T Cell Migration and Cell-Cell Contact Dynamics to Enhance Viral Spread.

August 21, 2020

Hon Koh W, Lopez P, Ajibola O, Parvarchian R, Mohammad U, Hnatiuk R, Kindrachuk J, Murooka TT. iScienc.

Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART

August 14, 2020

Gantner P, Pagliuzza A, Pardons M, Ramgopal M, Routy JP, Fromentin R and Chomont N. Nature Communications

Improving HIV Outgrowth by Optimizing Cell-Culture Conditions and Supplementing With all-trans Retinoic Acid.

May 15, 2020

Zhang Y, Planas D, Marchand LR, Massanella M, Chen H, Wacleche VS, Gosselin A, Goulet J-P, Filion M, Routy J-PChomont N and Ancuta P. Frontiers in Microbiology

The Bacterium Akkermansia muciniphila: A Sentinel for Gut Permeability and Its Relevance to HIV-Related Inflammation.

April 9, 2020

Ouyang J, Lin J, Isnard S, Fombuena B, Peng X, Marette A, Routy B, Messaoudene M, Chen Y, Routy J-P. Frontiers in Immunology. 

The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies.

April 8, 2020

Cohn LB, Chomont N, Deeks SG. Cell Host Microbe. 

Metformin effect on gut microbiota: insights for HIV-related inflammation

Ouyang J, Isnard S, Lin J, Fombuena B, Marette A, Routy B, Chen Y, Routy JP. AIDS research and Therapy. 

March 10, 2020

January 1, 2020

Despite early antiretroviral therapy effector memory and follicular helper CD4 T cells are major reservoirs in visceral lymphoid tissues of SIV-infected macaques.

November 14th, 2019

Differential Dynamics of Regulatory T-Cell and Th17 Cell Balance in Mesenteric Lymph Nodes and Blood following Early Antiretroviral Initiation during Acute Simian Immunodeficiency Virus Infection.

September 12th, 2019

HIV Infection Stabilizes Macrophage-T Cell Interactions To Promote Cell-Cell HIV Spread.

Lopez PKoh WHHnatiuk RMurooka TT. J. Virology

August 28th, 2019

HIV diversity and genetic compartmentalization in blood and testes during suppressive antiretroviral therapy.

June 12th, 2019

Expression of MDM2 in Macrophages Promotes the Early Postentry Steps of HIV-1 Infection through Inhibition of p53.

March 21st, 2019

HIV-1 is rarely detected in blood and colon myeloid cells during viral-suppressive antiretroviral therapy.

March 11th, 2019

Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection.

February 27th, 2019

PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals.

February 18th, 2019

Host mRNA decay proteins influence HIV-1 replication and viral gene expression in primary monocyte-derived macrophages.

February 7th, 2019

Shringar Rao, Raquel Amorim, Meijuan Niu, Yann Breton, Michel J. Tremblay and Andrew J. Mouland. Retrovirology.

Genetic complexity in the replication-competent latent HIV reservoir increases with untreated infection duration in infected youth.

February 1st, 2019

Medical Assistance in Death as a Unique Opportunity to Advance HIV Cure Research.

January 31rst, 2019

HIV-1 Balances the Fitness Costs and Benefits of Disrupting the Host Cell Actin Cytoskeleton Early after Mucosal Transmission.

January 9th, 2019

HIV subtype and Nef-mediated immune evasion function correlate with viral reservoir size in early-treated individuals.

January 2nd, 2019

Implications of HIV-1 Nef for "Shock and Kill" Strategies to Eliminate Latent Viral Reservoirs.

November 30th, 2018

Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants

November 27th, 2018