Publications
Targeting Th17cells in HIV-1 remission / cure interventions
July 2022
Fert A, Marchand LR, Wiche Salinas T R, Ancuta P
Bryostatin-1 Decreases HIV-1 Infection and Viral Production in
Human Primary Macrophages.
February 2022
Hany L, Turmel M, Barat C, Ouellet M, Tremblay M J
T cell migration potentiates HIV infection by enhancing viral fusion and integration.
February 2022
Lopex P, Ajibola O, Pagiluzza A, Zayats R, Hon Koh W, Herschhorn A, Chomont N, Murooka T
Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth
November 2021
Salinas TRW, Zhang Y, Sarnello D, Zhyvoloup A, Raymond Marchanda L, Planas D, Lodha M, Chatterjee D, Karwacz K, Oxenford S, Routy JP, Madsen H, Ancuta P, and Fassati A. PNAS
LILAC pilot study: Effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy
March 2021
February 24 2021
February 15 2021
Peculiar Phenotypic and Cytotoxic Features of Pulmonary Mucosal CD8 T Cells in People Living with HIV Receiving Long-Term Antiretroviral Therapy
December 14 2020
HIV Infection and Persistence in Pulmonary Mucosal Double Negative T Cells In Vivo
November 23 2020
Early Antiretroviral Therapy Prevents Viral Infection of Monocytes and Inflammation in Simian Immunodeficiency Virus-Infected Rhesus Macaques
October 27 2020
Pharmacological Inhibition of PPARy Boosts HIV Reactivation and Th17 Effector Functions, While Preventing Progeny Virion Release and de novo Infection
September 30 2020
Interleukin-1β Triggers p53-Mediated Downmodulation of CCR5 and HIV-1 Entry in Macrophages through MicroRNAs 103 and 107
September 29 2020
HIV enters deep sleep in people who naturally control the virus
September 2020
Distinct viral reservoirs in individuals with spontaneous control of HIV-1
September 2020
Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont N, Bar KJ, Yu XG, Lichterfeld M, Alcami J, Hazuda D, Bushman F, Siliciano JD, Betts MR,Spivak AM, Planelles V, Hahn BH, Smith DM, Ho Y, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJ, Kostman J, Mounzer K, Caskey M, Fox L, Frank I,Riley JL, Tebas P, Montaner LJ. Nature Med.
Recommendations for measuring HIV reservoir size in cure-directed clinical trials
September 7, 2020
Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont N, Bar KJ, Yu XG, Lichterfeld M, Alcami J, Hazuda D, Bushman F, Siliciano JD, Betts MR,Spivak AM, Planelles V, Hahn BH, Smith DM, Ho Y, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJ, Kostman J, Mounzer K, Caskey M, Fox L, Frank I,Riley JL, Tebas P, Montaner LJ. Nature Med.
HIV-Captured DCs Regulate T Cell Migration and Cell-Cell Contact Dynamics to Enhance Viral Spread.
August 21, 2020
Hon Koh W, Lopez P, Ajibola O, Parvarchian R, Mohammad U, Hnatiuk R, Kindrachuk J, Murooka TT. iScienc.
Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART
August 14, 2020
Gantner P, Pagliuzza A, Pardons M, Ramgopal M, Routy JP, Fromentin R and Chomont N. Nature Communications
Improving HIV Outgrowth by Optimizing Cell-Culture Conditions and Supplementing With all-trans Retinoic Acid.
May 15, 2020
Zhang Y, Planas D, Marchand LR, Massanella M, Chen H, Wacleche VS, Gosselin A, Goulet J-P, Filion M, Routy J-P, Chomont N and Ancuta P. Frontiers in Microbiology
The Bacterium Akkermansia muciniphila: A Sentinel for Gut Permeability and Its Relevance to HIV-Related Inflammation.
April 9, 2020
Ouyang J, Lin J, Isnard S, Fombuena B, Peng X, Marette A, Routy B, Messaoudene M, Chen Y, Routy J-P. Frontiers in Immunology.
The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies.
April 8, 2020
Cohn LB, Chomont N, Deeks SG. Cell Host Microbe.
Metformin effect on gut microbiota: insights for HIV-related inflammation
Ouyang J, Isnard S, Lin J, Fombuena B, Marette A, Routy B, Chen Y, Routy JP. AIDS research and Therapy.
March 10, 2020
Plasma Levels of C-Type Lectin REG3α and Gut Damage in People With Human Immunodeficiency Virus
January 1, 2020
Despite early antiretroviral therapy effector memory and follicular helper CD4 T cells are major reservoirs in visceral lymphoid tissues of SIV-infected macaques.
November 14th, 2019
Differential Dynamics of Regulatory T-Cell and Th17 Cell Balance in Mesenteric Lymph Nodes and Blood following Early Antiretroviral Initiation during Acute Simian Immunodeficiency Virus Infection.
Yero A, Farnos O, Rabezanahary H, Racine G, Estaquier J, Jenabian MA. J. Virology
September 12th, 2019
HIV Infection Stabilizes Macrophage-T Cell Interactions To Promote Cell-Cell HIV Spread.
Lopez P, Koh WH, Hnatiuk R, Murooka TT. J. Virology
August 28th, 2019
HIV diversity and genetic compartmentalization in blood and testes during suppressive antiretroviral therapy.
Miller RL, Ponte R, Jones BR, Kinloch NN, Omondi FH, Jenabian MA, Dupuy FP, Fromentin R, Brassard P, Mehraj V, Chomont N, Poon AFY, Joy JB, Brumme Z, Routy JP; ORCHID study group. J. Virology
June 12th, 2019
Expression of MDM2 in Macrophages Promotes the Early Postentry Steps of HIV-1 Infection through Inhibition of p53.
March 21st, 2019
Breton Y, Desrosiers V, Ouellet M, Deshiere A, Torresilla C, Cohen ÉA, Tremblay MJ. J. Virology
HIV-1 is rarely detected in blood and colon myeloid cells during viral-suppressive antiretroviral therapy.
March 11th, 2019
Cattin A, Salinas TRW, Gosselin A, Planas D, Shacklett B, Cohen ÉA, Ghali MP, Routy JP, Ancuta P. AIDS
Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection.
February 27th, 2019
Pardons M, Baxter AE, Massanella M, Pagliuzza A, Fromentin R, Dufour C, Leyre L, Routy JP, Kaufmann DE, Chomont N. PLoS Pathogen.
PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals.
February 18th, 2019
Fromentin R, DaFonseca S, Costiniuk CT, El-Far M, Procopio FA, Hecht FM, Hoh R, Deeks SG, Hazuda DJ6, Lewin SR, Routy JP, Sékaly RP, Chomont N. Nature Communications.
Genetic complexity in the replication-competent latent HIV reservoir increases with untreated infection duration in infected youth.
February 1st, 2019
Medical Assistance in Death as a Unique Opportunity to Advance HIV Cure Research.
January 31rst, 2019
HIV-1 Balances the Fitness Costs and Benefits of Disrupting the Host Cell Actin Cytoskeleton Early after Mucosal Transmission.
January 9th, 2019
HIV subtype and Nef-mediated immune evasion function correlate with viral reservoir size in early-treated individuals.
January 2nd, 2019
Omondi FH, Chandrarathna S, Mujib S, Brumme CJ, Jin SW, Sudderuddin H, Miller R, Rahimi A, Laeyendecker O, Bonner P, Yue FY, Benko E, Kovacs CM, Brockman MA, Ostrowski M, Brumme ZL. J. Virology
Implications of HIV-1 Nef for "Shock and Kill" Strategies to Eliminate Latent Viral Reservoirs.
November 30th, 2018
Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants
November 27th, 2018
Phylogenetic approach to recover integration dates of latent HIV sequences within-host
September 5th, 2018
Bradley R. Jones, Natalie N. Kinloch, Joshua Horacsek, Bruce Ganase, Marianne Harris, P. Richard Harrigan, R. Brad Jones, Mark A. Brockman, Jeffrey B. Joy, Art F. Y. Poon, and Zabrina L. Brumme. PNAS
Socio-economic status and time trends associated with early ART initiation following primary HIV infection in Montreal, Canada: 1996 to 2015.
Feb 6, 2018
Mehraj V, Cox J, Lebouché B, Costiniuk C, Cao W, Li T, Ponte R, Thomas R, Szabo J, Baril JG, Trottier B, Côté P, LeBlanc R, Bruneau J, Tremblay C, Routy JP; Montreal Primary HIV-Infection Study Group. J Int AIDS Soc. 2018 Feb;21(2). doi: 10.1002/jia2.25034.
Inhibition of NF-κB-dependent HIV-1 replication by the marine natural product bengamide A.
April 15, 2018
Tietjen I, Williams DE, Read S, Kuang XT, Mwimanzi P, Wilhelm E, Markle T, Kinloch NN, Naphen CN, Tenney K, Mesplède T, Wainberg MA, Crews P, Bell B5, Andersen RJ, Brumme ZL, Brockman MA. Antiviral Res. 152:94-103. doi: 10.1016/j.antiviral.
ADAR1 and PKR, interferon stimulated genes with clashing effects on HIV-1 replication.
March 26, 2018
Radetskyy R, Daher A, Gatignol A. Cytokine Growth Factor Rev. pii: S1359-6101(18)30032-7. doi: 10.1016/j.cytogfr.2018.03.007. [Epub ahead of print]
Use of (1→3)-β-D-Glucan for diagnosis and management of invasive mycoses in HIV-infected patients.
May 31st, 2018
Farhour Z, Mehraj V, Chen J, Ramendra R, Lu H, Routy JP. Mycoses. 2018 May 31;. [Epub ahead of print]
Contrasting effect of the latency-reversing agents bryostatin-1 and JQ1 on astrocyte-mediated neuroinflammation and brain neutrophil invasion.
Dec 11, 2017
Proust A, Barat C, Leboeuf M, Drouin J, Tremblay MJ. J Neuroinflammation. 2017 Dec 11;14(1):242. doi: 10.1186/s12974-017-1019-y.
The Biology of Monocytes and Dendritic Cells: Contribution to HIV Pathogenesis.
Feb 6, 2018
Wacleche VS, Tremblay CL, Routy JP, Ancuta P. Viruses. 10(2). pii: E65. doi: 10.3390/v10020065.
Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling.
Jan 16, 2018
Wong RW, Lingwood CA, Ostrowski MA, Cabral T, Cochrane A. Sci Rep. 8(1):850. doi: 10.1038/s41598-018-19298-x.
cIAP1/2-TRAF2-SHP-1-Src-MyD88 Complex Regulates Lipopolysaccharide-Induced IL-27 Production through NF-κB Activation in Human Macrophages.
Jan 22, 2018
Busca A, Konarski Y, Gajanayaka N, O'Hara S, Angel J, Kozlowski M, Kumar A. J Immunol.pii: ji1700199. doi: 10.4049/jimmunol.1700199. [Epub ahead of print]
Inducible HIV RNA transcription assays to measure HIV persistence: pros and cons of a compromise.
Jan 17, 2018
Plantin J, Massanella M, Chomont N. Retrovirology.15(1):9. doi: 10.1186/s12977-017-0385-y.
The oncolytic virus, MG1, targets and eliminates latently HIV-1-infected cells: implications for an HIV cure.
Dec 8, 2017
Ranganath N, Sandstrom TS, Burke Schinkel SC, Côté SC, Angel JB. The Journal of Infectious Diseases.
Xenobiotic Nuclear Receptors Pregnane X Receptor and Constitutive Androstane Receptor Regulate Antiretroviral Drug Efflux Transporters at the Blood-Testis Barrier.
December, 2017
Managing Expectations of an HIV Cure: What Should We Expect?
Nov 22, 2017
Reinhard, RJ. AIDS Res Hum Retroviruses. doi: 10.1089/AID.2017.0247. [Epub ahead of print]
HIV-1 NC-induced stress granule assembly and translation arrest are inhibited by the dsRNA binding protein Staufen1.
Nov 10, 2017
Rao S, Cinti A, Temzi A, Amorim R, You JC, Mouland AJ. HIV-1 NC-induced stress granule assembly and translation arrest are inhibited by the dsRNA binding protein Staufen1. RNA. 2017 Nov 10. pii: rna.064618.117. doi: 10.1261/rna.064618.117. [Epub ahead of print]
Very early antiretroviral therapy permits CD8 T cells to keep HIV reservoirs at bay.
Nov 5, 2017
Routy JP, Mehraj V. Ann Transl Med. 2017 Nov;5(21):434. doi: 10.21037/atm.2017.08.38.
The Interferon-induced Protein Kinase R: the base of a riboprotein scaffolding regulating the Human Immunodeficiency Virus.
Nov 2017
The Th17 Lineage: From Barrier Surfaces homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis.
Oct 19, 2017
Sue Waclech V, Landay A, Routy JP, Ancuta P. Viruses. 19;9(10). pii: E303. doi: 10.3390/v9100303.
Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain.
Oct 16, 2017
Asahchop EL, Meziane O, Mamik MK, Chan WF, Branton WG, Resch L, Gill MJ, Haddad E, Guimond JV, Wainberg MA, Baker GB, Cohen EA, Power C. Retrovirology. 16;14(1):47. doi: 10.1186/s12977-017-0370-5.
Characterization of myeloid cell populations in human testes collected after sex reassignment surgery.
Oct 11, 2017
Ponte R, Dupuy F, Brimo F, Mehraj V, Brassard P, Belanger M, Yurchenko E, Ali Jenabian M, Bernard NF, Routy JP, for the ORCHID study group. Journal of Reproductive Immunology. (2018) 16-24. doi: 10.1016/j.jri.2017.10.043
Host MicroRNAs-221 and -222 Inhibit HIV-1 Entry in Macrophages by Targeting the CD4 Viral Receptor.
Oct 3, 2017
Lodge R, Ferreira Barbosa JA, Lombard-Vadnais F, Gilmore JC, Deshiere A, Gosselin A, Wiche Salinas TR, Bego MG, Power C, Routy JP, Ancuta P, Tremblay MJ, Cohen ÉA. Cell Rep. doi: 10.1016/j.celrep.2017.09.030.
The evaluation of risk-benefit ratio for gut tissue sampling in HIV cure research.
Oct 1, 2017
The Croton megalobotrys Müll Arg. traditional medicine in HIV/AIDS management: Documentation of patient use, in vitro activation of latent HIV-1 provirus, and isolation of active phorbol esters.
Sept 29, 2017
Tietjen I, Ngwenya BN, Fotso G, Williams DE, Simonambango S, Ngadjui BT, Andersen RJ, Brockman MA, Brumme ZL,Andrae-Marobela K. J Ethnopharmacol. 29;211:267-277. doi: 10.1016/j.jep.2017.09.038. [Epub ahead of print]
Antiviral Activity of Bictegravir and Cabotegravir Against Integrase Inhibitor Resistant SIVmac239 and HIV-1.
Sept 18, 2017
Hassounah SA, Alikhani A, Oliveira M, Bharaj S, Ibanescu RI, Osman N, Xu HT, Brenner BG, Mesplède T, Wainberg MA. Antimicrob Agents Chemorther, 18 sept 2017. doi: 10.1128/AAC.01695-17. [Epub ahead of print]
RNA flow cytometric FISH for investigations into HIV immunology, vaccination and cure strategies.
Sept 12, 2017
Baxter AE, Niessl J, Morou A, Kaufmann DE. AIDS Res Ther 2017 DOI 10.1186/s12981-017-0171-x
Potential contribution of gut microbiota and systemic inflammation on HIV vaccine effectiveness and vaccine design.
Sept 12, 2017
Routy JP and Mehraj V. AIDS Res Ther 2017. DOI 10.1186/s12981-017-0164-9
Multiparametric characterization of rare HIV-infected cells using an RNA-flow FISH technique.
Sept 7, 2017
Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Massanella M, Brassard N, Alsahafi N, Routy JP, Finzi A, Chomont N,Kaufmann D. Nat Protocol. doi: 10.1038/nprot.2017.079.
Pharmacologic HIV-1 Nef blockade promotes CD8 T cell–mediated elimination of latently HIV-1–infected cells in vitro.
Sept 7, 2017
Mujib S, Saiyed A, Fadel S, Bozorgzad A, Aidarus N, Yun Yue F, Benko E, Kovacs C, Emert-Sedlak LA, Smithgall TE, Ostrowski MA. JCI Insight. DOI: 10.1172/jci.insight.93684.
HIV-1 selectively targets gut-homing CCR6+CD4+ T-cells via mTOR-dependent mechanisms.
Aug 3, 2017
Planas D, Zhang Y, Monteiro P, Goulet JP, Gosselin A, Grandvaux N, Hope TJ, Fassati A, Routy JP, Ancuta P. JCI Insight. doi: 10.1172 /jci.insight.93230.
Comprehensive cross-clade characterization of antibody-mediated recognition, complement-mediated lysis and cell-mediated cytotoxicity of HIV-1 envelope specific antibodies towards the eradication of the HIV-1 reservoir.
Jul 27, 2017
Mujib S, Liu J, Rahman AKMN, Schwartz JA, Bonner P, Yue FY, Ostrowski MA. J Virol. 27;91(16). pii: e00634-17. doi: 10.1128/JVI.00634-17. Print 2017 Aug 15.
HIV-1 enhances mTORC1 activity and repositions lysosomes to the periphery by co-opting Rag GTPase.
Jul 14 2017
Cinti A, Le Sage V, Mirev MP, Valiente-Echeverria F, Crossie C, Miron MJ, Pante N, Oliver M, Mouland AJ. Scientific Reports. 7(1):5515.
Global mapping of the macrophage-HIV-1 transcriptome reveals that productive infection induces remodeling of host cell DNA and chromatin.
Jul 12 2017
Deshiere A, Joly-Beauparlant C, Breton Y, Ouellet M, Raymond F, Lodge R, Barat C, Roy M-A, Corbeil J, Tremblay MJ. Scientific Reports. 7(1):5238.
HIV-1 and HIV-Tat inhibit LPS-induced IL-27 production in human macrophages by distinct intracellular signaling pathway.
Jul 11, 2017
Gajanayaka N, O’Hara S, Konarski Y, Fernandes J, Muthumani K, Kozlowski M, Angel JB, Kumar A. J Leukoc Biol. 2017 Sep;102(3):925-939. doi: 10.1189/jlb.4A0716-332RR. Epub 2017 Jul 11.
Impairment of the type I interferon response by HIV-1: Potential targets for HIV eradication.
Apr 24, 2017
Sandstrom TS, Ranganath N, Angel JB. Cytokine Growth Factor Rev. 37:1-16. doi: 10.1016/j.cytogfr.2017.04.004. Epub 2017 Apr 24.
Tim-3 is a marker of plasmacytoid dendritic cell dysfunction during HIV infection and is associated with the recruitment of IRF7 and p85 into lysosomes and with the submembrane displacement of TLR9.
Mar 6, 2017
Schwartz JA, Clayton KL, Mujib S, Zhang H, Rahman AK, Liu J, Yue FY, Benko E, Kovacs C, Ostrowski MA. J Immunol. 2017 Apr 15;198(8):3181-3194. doi: 10.4049/jimmunol.1601298. Epub 2017 Mar 6.
HIV-1 Vpu downmodulates ICAM-1 expression resulting in decreased killing of infected CD4+ T cells by NK cells.
Mar 29, 2017
Sugden SM, Pham TN, Cohen EA. Journal of virology, 91(8): e02442-16.
CD4 T follicular helper cells and HIV infection: Friends or enemies?
Feb 20, 2017
Moukambi F, Rodrigues V, Fortier Y, Rabezanahary H, Borde C, Krust B, Andreani G, Silvestre R, Petrovas C, Laforge M, Estaquier J. Frontiers in immunology, 8:135.
HIV persists in CCR6+CD4+ T-cells from colon and blood during antiretroviral therapy.
Jan 2, 2017
Gosselin A, Wiche Salinas TR, Planas D, Wacleche VS, Zhang Y, Fromentin R, Chomont N, Cohen EA, Shacklett B, Mehraj V, Ghali MP, Routy JP, Ancuta P. AIDS2017, 31(1): 35-48.
Ebola virus VP35 blocks stress granule assembly.
Dec 23, 2016
Le Sage V, Cinti A, McCarthy S, Amorim R, Rao S, Daino GL, Tramontano E, Branch DR, Mouland AJ. Virology. 2017 Feb;502:73-83. doi: 10.1016/j.virol.2016.12.012. Epub 2016 Dec 23.
HIV-1 latency-reversing agents prostratin and bryostatin-1 induce blood-brain barrier disruption/inflammation and modulate leukocyte adhesion/transmigration.
Dec 19, 2016
Dental C, Proust A, Ouellet M, Barat C, Tremblay MJ. J Immunol. Feb 1;198(3):1229-1241. doi: 10.4049/jimmunol.1600742. Epub 2016 Dec 19.
Immune tolerance properties of the testicular tissue as a viral sanctuary site in ART-treated HIV-infected adults.
Nov 28, 2016
Jenabian MA, Costiniuk CT, Mehraj V, Ghazawi FM, Fromentin R, Brousseau J, Brassard P, Belanger M, Ancuta P, Bendayan R,Chomont N, Routy JP; for the Orchid study group. AIDS, 30(18): 2777-2786.
Enhancing virion tethering by BST2 sensitizes productively and latently HIV-infected T cells to ADCC mediated by broadly neutralizing antibodies.
Nov 17, 2016
Pham TN, Lukhele S, Dallaire F, Perron G, Cohen EA. Scientific reports, 6: 37225.
AMPK in Pathogens.
Nov 4, 2016
Mesquita I, Moreira D, Sampaio-Marques B, Laforge M, Cordeiro-da-Silva A, Ludovico P, Estaquier J, Silvestre R. Experientia Supplementum, 107: 287-323.
Differential control of BST2 restriction and plasmacytoid dendritic cell antiviral response by antagonists encoded by HIV-1 group M and O strains.
Oct 28, 2016
Bego MG, Cong L, Mack K, Kirchhoff F, Cohen EA. Journal of virology 2016, 90(22): 10236-10246.
Type I interferon responses are impaired in latently HIV infected cells.
Sept 9, 2016
Ranganath N, Sandstrom TS, Fadel S, Cote SC, Angel JB. Retrovirology 2016, 13(1): 66.
Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals.
Aug 18, 2016
Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Charlebois R, Massanella M, Brassard N, Alsahafi N, Delgado G-G,Routy JP, Walker BD, Finzi A, Chomont N, Kaufmann DE. Cell Host Microbe. 2016 Sep 14;20(3):368-380. doi: 10.1016/j.chom.2016.07.015. Epub 2016 Aug 18.
Kynurenine Reduces Memory CD4 T-Cell Survival by Interfering with Interleukin-2 Signaling Early during HIV-1 Infection.
Aug 12, 2016
Dagenais-Lussier X, Aounallah M, Mehraj V, El-Far M, Tremblay C, Sekaly RP, Routy JP, van Grevenynghe J; for the Montreal Primary Infection Study Group. Journal of virology, 90(17): 7967-7979
Role and modulation of drug transporters in HIV-1 therapy.
May 13, 2016
Alam C, Whyte-Allman SK, Omeragic A, Bendayan R. Adv Drug Deliv Rev. Aug 1;103:121-43. doi: 10.1016/j.addr.2016.05.001. Epub 2016 May 13.
Bryostatin-1 Decreases HIV-1 Infection and Viral Production in
Human Primary Macrophages.
February 2022
T cell migration potentiates HIV infection by enhancing viral fusion and integration.
February 2022
Lopex P, Ajibola O, Pagiluzza A, Zayats R, Hon Koh W,Herschhorn A, Chomont N, Murooka T
Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth
November 2021
Salinas TRW, Zhang Y, Sarnello D, Zhyvoloup A, Raymond Marchanda L, Planas D, Lodha M, Chatterjee D, Karwacz K, Oxenford S, Routy JP, Madsen H, Ancuta P, and Fassati A. PNAS
LILAC pilot study: Effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy
March 2021
February 24 2021
February 15 2021
Peculiar Phenotypic and Cytotoxic Features of Pulmonary Mucosal CD8 T Cells in People Living with HIV Receiving Long-Term Antiretroviral Therapy
December 14 2020
HIV Infection and Persistence in Pulmonary Mucosal Double Negative T Cells In Vivo
November 23 2020
Early Antiretroviral Therapy Prevents Viral Infection of Monocytes and Inflammation in Simian Immunodeficiency Virus-Infected Rhesus Macaques
October 27 2020
Pharmacological Inhibition of PPARy Boosts HIV Reactivation and Th17 Effector Functions, While Preventing Progeny Virion Release and de novo Infection
September 30 2020
Interleukin-1β Triggers p53-Mediated Downmodulation of CCR5 and HIV-1 Entry in Macrophages through MicroRNAs 103 and 107
September 29 2020
HIV enters deep sleep in people who naturally control the virus
September 2020
Distinct viral reservoirs in individuals with spontaneous control of HIV-1
September 2020
Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont N, Bar KJ, Yu XG, Lichterfeld M, Alcami J, Hazuda D, Bushman F, Siliciano JD, Betts MR,Spivak AM, Planelles V, Hahn BH, Smith DM, Ho Y, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJ, Kostman J, Mounzer K, Caskey M, Fox L, Frank I,Riley JL, Tebas P, Montaner LJ. Nature Med.
Recommendations for measuring HIV reservoir size in cure-directed clinical trials
September 7, 2020
Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont N, Bar KJ, Yu XG, Lichterfeld M, Alcami J, Hazuda D, Bushman F, Siliciano JD, Betts MR,Spivak AM, Planelles V, Hahn BH, Smith DM, Ho Y, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJ, Kostman J, Mounzer K, Caskey M, Fox L, Frank I,Riley JL, Tebas P, Montaner LJ. Nature Med.
HIV-Captured DCs Regulate T Cell Migration and Cell-Cell Contact Dynamics to Enhance Viral Spread.
August 21, 2020
Hon Koh W, Lopez P, Ajibola O, Parvarchian R, Mohammad U, Hnatiuk R, Kindrachuk J, Murooka TT. iScienc.
Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART
August 14, 2020
Gantner P, Pagliuzza A, Pardons M, Ramgopal M, Routy JP, Fromentin R and Chomont N. Nature Communications
Improving HIV Outgrowth by Optimizing Cell-Culture Conditions and Supplementing With all-trans Retinoic Acid.
May 15, 2020
Zhang Y, Planas D, Marchand LR, Massanella M, Chen H, Wacleche VS, Gosselin A, Goulet J-P, Filion M, Routy J-P, Chomont N and Ancuta P. Frontiers in Microbiology
The Bacterium Akkermansia muciniphila: A Sentinel for Gut Permeability and Its Relevance to HIV-Related Inflammation.
April 9, 2020
Ouyang J, Lin J, Isnard S, Fombuena B, Peng X, Marette A, Routy B, Messaoudene M, Chen Y, Routy J-P. Frontiers in Immunology.
The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies.
April 8, 2020
Cohn LB, Chomont N, Deeks SG. Cell Host Microbe.
Metformin effect on gut microbiota: insights for HIV-related inflammation
Ouyang J, Isnard S, Lin J, Fombuena B, Marette A, Routy B, Chen Y, Routy JP. AIDS research and Therapy.
March 10, 2020
Plasma Levels of C-Type Lectin REG3α and Gut Damage in People With Human Immunodeficiency Virus
January 1, 2020
Despite early antiretroviral therapy effector memory and follicular helper CD4 T cells are major reservoirs in visceral lymphoid tissues of SIV-infected macaques.
November 14th, 2019
Differential Dynamics of Regulatory T-Cell and Th17 Cell Balance in Mesenteric Lymph Nodes and Blood following Early Antiretroviral Initiation during Acute Simian Immunodeficiency Virus Infection.
Yero A, Farnos O, Rabezanahary H, Racine G, Estaquier J, Jenabian MA. J. Virology
September 12th, 2019
HIV Infection Stabilizes Macrophage-T Cell Interactions To Promote Cell-Cell HIV Spread.
Lopez P, Koh WH, Hnatiuk R, Murooka TT. J. Virology
August 28th, 2019
HIV diversity and genetic compartmentalization in blood and testes during suppressive antiretroviral therapy.
Miller RL, Ponte R, Jones BR, Kinloch NN, Omondi FH, Jenabian MA, Dupuy FP, Fromentin R, Brassard P, Mehraj V, Chomont N, Poon AFY, Joy JB, Brumme Z, Routy JP; ORCHID study group. J. Virology
June 12th, 2019
Expression of MDM2 in Macrophages Promotes the Early Postentry Steps of HIV-1 Infection through Inhibition of p53.
March 21st, 2019
Breton Y, Desrosiers V, Ouellet M, Deshiere A, Torresilla C, Cohen ÉA, Tremblay MJ. J. Virology
HIV-1 is rarely detected in blood and colon myeloid cells during viral-suppressive antiretroviral therapy.
March 11th, 2019
Cattin A, Salinas TRW, Gosselin A, Planas D, Shacklett B, Cohen ÉA, Ghali MP, Routy JP, Ancuta P. AIDS
Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection.
February 27th, 2019
Pardons M, Baxter AE, Massanella M, Pagliuzza A, Fromentin R, Dufour C, Leyre L, Routy JP, Kaufmann DE, Chomont N. PLoS Pathogen.
PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals.
February 18th, 2019
Fromentin R, DaFonseca S, Costiniuk CT, El-Far M, Procopio FA, Hecht FM, Hoh R, Deeks SG, Hazuda DJ6, Lewin SR, Routy JP, Sékaly RP, Chomont N. Nature Communications.
Genetic complexity in the replication-competent latent HIV reservoir increases with untreated infection duration in infected youth.
February 1st, 2019
Medical Assistance in Death as a Unique Opportunity to Advance HIV Cure Research.
January 31rst, 2019
HIV-1 Balances the Fitness Costs and Benefits of Disrupting the Host Cell Actin Cytoskeleton Early after Mucosal Transmission.
January 9th, 2019
HIV subtype and Nef-mediated immune evasion function correlate with viral reservoir size in early-treated individuals.
January 2nd, 2019
Omondi FH, Chandrarathna S, Mujib S, Brumme CJ, Jin SW, Sudderuddin H, Miller R, Rahimi A, Laeyendecker O, Bonner P, Yue FY, Benko E, Kovacs CM, Brockman MA, Ostrowski M, Brumme ZL. J. Virology