Publications
Theme 1
Active reservoirs in tissues and viral rebound
Theme 2
Persistence and immune escape of HIV reservoir cells in tissues
Theme 3
Therapeutic interventions
Community
Community surveys
2025
Budigalimab, an anti-PD-1 inhibitor, for people living with HIV-1: a randomized, placebo-controlled phase 1b study
Nature Medicine, November 2025
Ramgopal MN, Lalezari JP, Pires Dos Santos AG, Krishnan P, Vaidya TR, Zhou F, Betman H, Dorr P, Mostafa NM, Alcaide ML, Felizarta F, Routy JP.
The CanCURE Survey: Gender-Based Differences in HIV Cure Research Priorities.
Journal of Personalized Medicine, December 2025
Lu J, Vulesevic B, Margolese S, Masching R, Tharao W, Cardinal C, Hedrich T, Mallais C, Dubé K, Cohen E, Chomont N, Costiniuk CT.
2024
Bivalent SMAC mimetic APG-1387 reduces HIV reservoirs and limits viral rebound in humanized mice
iScience, November 2024
2023
Near full-length HIV sequencing in multiple tissues collected postmortem reveals shared clonal expansions across distinct reservoirs during ART
Cell Reports, September 2023
Dufour C, Ruiz MJ, Pagliuzza A, Richard C, Shahid A, Fromentin R, Ponte R, Cattin A, Wiche Salinas TR, Salahuddin S, Sandstrom T, Schinkel SB, Costiniuk CT, Jenabian MA, Ancuta P, Routy JP, Cohen ÉA, Brumme ZL, Power C, Angel JB, Chomont N.
Identifying physiological tissue niches that support the HIV reservoir in T cells
mBio, September 2023
Ikeogu N, Ajibola O, Zayats R, Murooka TT.
Early ART reduces viral seeding and innate immunity in liver and lungs of SIV-infected macaques
JCI Insight, July 2023
Clain JA, Rabezanahary H, Racine G, Boutrais S, Soundaramourty C, Joly Beauparlant C, Jenabian MA, Droit A, Ancuta P, Zghidi-Abouzid O, Estaquier J.
HIV rapidly targets a diverse pool of CD4+ T cells to establish productive and latent infections
Immunity, March 2023
Gantner P, Buranapraditkun S, Pagliuzza A, Dufour C, Pardons M, Mitchell JL, Kroon E, Sacdalan C, Tulmethakaan N, Pinyakorn S, Robb ML, Phanuphak N, Ananworanich J, Hsu D, Vasan S, Trautmann L, Fromentin R, Chomont N.
Generation of functional human T cell development in NOD/SCID/IL2rynull humanized mice without using fetal tissue: Application as a model of HIV infection and persistence
StemCell Reports, February 2023
Colas C, Volodina O, Béland K, Pham TNQ, Li Y, Dallaire F, Soulard C, Lemieux W, Colamartino ABL, Tremblay-Laganière C, Dicaire R, Guimond J, Vobecky S, Poirier N, Patey N, Cohen ÉA, Haddad E.
Phenotypic characterization of single CD4+ T cells harboring genetically intact and inducible HIV genomes
Nature Communications, February 2023
Dufour C, Richard C, Pardons M, Massanella M, Ackaoui A, Murrell B, Routy B, Thomas R, Routy JP, Fromentin R, Chomont N.
2022
T cell migration potentiates HIV infection by enhancing viral fusion and integration
Cell Reports, February 2022
Lopex P, Ajibola O, Pagiluzza A, Zayats R, Hon Koh W, Herschhorn A, Chomont N, Murooka T
Willingness of Older Canadians with HIV to Participate in HIV Cure Research Near and After the End of Life: A Mixed-Method Study.
AIDS Research and Human Retroviruses, August 2022
Lessard D, Dubé K, Bilodeau M, Keeler P, Margolese S, Rosenes R, Sinyavskaya L, Durand M, Benko E, Kovacs C, Guerlotté C, Tharao W, Arnold K, Masching R, Taylor D, Sousa J, Ostrowski M, Taylor J, Kaytes A, Smith D, Gianella S, Chomont N, Angel JB, Routy JP, Cohen ÉA, Lebouché B, Costiniuk CT
Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth
PNAS, November 2021
Salinas TRW, Zhang Y, Sarnello D, Zhyvoloup A, Raymond Marchanda L, Planas D, Lodha M, Chatterjee D, Karwacz K, Oxenford S, Routy JP, Madsen H, Ancuta P, and Fassati A
LILAC pilot study: Effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy
EBioMedicine, March 2021
Planas D, Pagliuzza A, Ponte R, Fert A, Marchand L.R, Massanella M, Gosselin A, Mehraj V, Dupuy F.P, Isnard S, Goulet J-P, Lesage S, , Ghali M.P, Angel J, Chomont N, Routy J-P, Ancuta P.
Beyond the Absence of CD4 T-Cell Count: A Novel Genetic CD4 T-Cell Deficiency Disorder With a Contingency Plan
Journal of Infectious Diseases, February 24 2021
Differences in HIV burden in the inflamed and non-inflamed colon from a person living with HIV and ulcerative colitis
Journal of Virus Eradication, February 15 2021
Peculiar Phenotypic and Cytotoxic Features of Pulmonary Mucosal CD8 T Cells in People Living with HIV Receiving Long-Term Antiretroviral Therapy
Journal of Immunology, December 14 2020
HIV Infection and Persistence in Pulmonary Mucosal Double Negative T Cells In Vivo
Journal of Virology, November 23 2020
Early Antiretroviral Therapy Prevents Viral Infection of Monocytes and Inflammation in Simian Immunodeficiency Virus-Infected Rhesus Macaques
Journal of Virology, October 27 2020
Pharmacological Inhibition of PPARy Boosts HIV Reactivation and Th17 Effector Functions, While Preventing Progeny Virion Release and de novo Infection
Pathogens and Immunity, September 30 2020
Interleukin-1β Triggers p53-Mediated Downmodulation of CCR5 and HIV-1 Entry in Macrophages through MicroRNAs 103 and 107
mBio, September 29 2020
HIV enters deep sleep in people who naturally control the virus
Nature, September 2020
Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART
Nature Communications, August 14, 2020
Gantner P, Pagliuzza A, Pardons M, Ramgopal M, Routy JP, Fromentin R, Chomont N.
Improving HIV Outgrowth by Optimizing Cell-Culture Conditions and Supplementing With all-trans Retinoic Acid.
Frontiers in Microbiology, May 15, 2020
Zhang Y, Planas D, Marchand LR, Massanella M, Chen H, Wacleche VS, Gosselin A, Goulet J-P, Filion M, Routy J-P, Chomont N, Ancuta P.
The Bacterium Akkermansia muciniphila: A Sentinel for Gut Permeability and Its Relevance to HIV-Related Inflammation.
Frontiers in Immunology, April 9, 2020
Ouyang J, Lin J, Isnard S, Fombuena B, Peng X, Marette A, Routy B, Messaoudene M, Chen Y, Routy J-P.
The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies.
Cell Host and Microbe, April 8, 2020
Cohn LB, Chomont N, Deeks SG.
Metformin effect on gut microbiota: insights for HIV-related inflammation
AIDS Research and Therapy, March 2020
Ouyang J, Isnard S, Lin J, Fombuena B, Marette A, Routy B, Chen Y, Routy JP.
Plasma Levels of C-Type Lectin REG3α and Gut Damage in People With Human Immunodeficiency Virus
Journal of Infectious Diseases, January 2020
Isnard S, Ramendra R, Dupuy FP, Lin J, Fombuena B, Kokinov N, Kema I, Jenabian M-A, Lebouché B, Costiniuk C, Ancuta P, Bernard NF, Silverman M, Lakatos P, Durand M, Tremblay C, Routy J-P.
Despite early antiretroviral therapy effector memory and follicular helper CD4 T cells are major reservoirs in visceral lymphoid tissues of SIV-infected macaques.
Mucosal Immunology, November 2019
Rabezanahary H, Moukambi F, Palesch D, Clain J, Racine G, Andreani G, Benmadid-Laktout G, Zghidi-Abouzid O, Soundaramourty C, Tremblay C, Silvestri G, Estaquier J.
Differential Dynamics of Regulatory T-Cell and Th17 Cell Balance in Mesenteric Lymph Nodes and Blood following Early Antiretroviral Initiation during Acute Simian Immunodeficiency Virus Infection.
Journal of Virology, September 2019
HIV diversity and genetic compartmentalization in blood and testes during suppressive antiretroviral therapy.
Journal of Virology, June 2019
Miller RL, Ponte R, Jones BR, Kinloch NN, Omondi FH, Jenabian MA, Dupuy FP, Fromentin R, Brassard P, Mehraj V, Chomont N, Poon AFY, Joy JB, Brumme Z, Routy JP; ORCHID study group.
Expression of MDM2 in Macrophages Promotes the Early Postentry Steps of HIV-1 Infection through Inhibition of p53.
Journal of Virology, March 2019
HIV-1 is rarely detected in blood and colon myeloid cells during viral-suppressive antiretroviral therapy.
AIDS, March 2019
Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection.
PLoS Pathogen, February 2019
Pardons M, Baxter AE, Massanella M, Pagliuzza A, Fromentin R, Dufour C, Leyre L, Routy JP, Kaufmann DE, Chomont N.
PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals.
Nature Communications, February 2019
Fromentin R, DaFonseca S, Costiniuk CT, El-Far M, Procopio FA, Hecht FM, Hoh R, Deeks SG, Hazuda DJ6, Lewin SR, Routy JP, Sékaly RP, Chomont N.
Medical Assistance in Death as a Unique Opportunity to Advance HIV Cure Research.
Clinical Infectious Diseases, January 2019
HIV subtype and Nef-mediated immune evasion function correlate with viral reservoir size in early-treated individuals.
Journal of Virology, January 2019
2021 and older
Phylogenetic approach to recover integration dates of latent HIV sequences within-host
PNAS, September 2018
Bradley R. Jones, Natalie N. Kinloch, Joshua Horacsek, Bruce Ganase, Marianne Harris, P. Richard Harrigan, R. Brad Jones, Mark A. Brockman, Jeffrey B. Joy, Art F. Y. Poon, and Zabrina L. Brumme.
Identification of Novel HIV-1 Latency-Reversing Agents from a Library of Marine Natural Products.
Viruses, June 2018
Richard K, Williams DE, de Silva ED, Brockman MA, Brummer ZL, Andersen RJ, Tietjen I.
Use of (1→3)-β-D-Glucan for diagnosis and management of invasive mycoses in HIV-infected patients.
Mycoses, May 2018
Inhibition of NF-κB-dependent HIV-1 replication by the marine natural product bengamide A.
Antiviral Research, April 2018
Tietjen I, Williams DE, Read S, Kuang XT, Mwimanzi P, Wilhelm E, Markle T, Kinloch NN, Naphen CN, Tenney K, Mesplède T, Wainberg MA, Crews P, Bell B5, Andersen RJ, Brumme ZL, Brockman MA.
cIAP1/2-TRAF2-SHP-1-Src-MyD88 Complex Regulates Lipopolysaccaride-Induced IL-27 Production through NF-kB Activation in Human Macrophages.
Journal of Immunology, March 2018
Busca A, Konarski Y, Gajanayaka N, O'Hara S, Angel J, Kozlowski M, Kumar A.
Socio-economic status and time trends associated with early ART initiation following primary HIV infection in Montreal, Canada: 1996 to 2015.
Journal of the International AIDS Society, February 2018
Mehraj V, Cox J, Lebouché B, Costiniuk C, Cao W, Li T, Ponte R, Thomas R, Szabo J, Baril JG, Trottier B, Côté P, LeBlanc R, Bruneau J, Tremblay C, Routy JP; Montreal Primary HIV-Infection Study Group.
The Biology of Monocytes and Dendritic Cells: Contribution to HIV Pathogenesis.
Viruses, February 2018
Wacleche VS, Tremblay CL, Routy JP, Ancuta P.
Inducible HIV RNA transcription assays to measure HIV persistence: pros and cons of a compromise.
Retrovirology, January 2018
Plantin J, Massanella M, Chomont N.
Regulation of CD4 Receptor and HIV-1 Entry by MicroRNAs-221 and -222 during Differentiation of THP-1 Cells.
Viruses, December 2017
​
Lodge R, Gilmore JC, Ferreira Barbosa JA, Lombard-Vadnais F, Cohen ÉA.
​
The oncolytic virus, MG1, targets and eliminates latently HIV-1-infected cells: implications for an HIV cure.
Journal of Infectious Diseases, December 2017
Ranganath N, Sandstrom TS, Burke Schinkel SC, Côté SC, Angel JB.
Xenobiotic Nuclear Receptors Pregnane X Receptor and Constitutive Androstane Receptor Regulate Antiretroviral Drug Efflux Transporters at the Blood-Testis Barrier.
Journal of Pharmacology and Experimental Therapeutics, December 2017
Very early antiretroviral therapy permits CD8 T cells to keep HIV reservoirs at bay.
Annals of Translational Medicine, November 2017
Routy JP, Mehraj V.
The Th17 Lineage: From Barrier Surfaces homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis.
Viruses, October 2017
Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain.
Oct 16, 2017
Asahchop EL, Meziane O, Mamik MK, Chan WF, Branton WG, Resch L, Gill MJ, Haddad E, Guimond JV, Wainberg MA, Baker GB, Cohen EA, Power C. Retrovirology. 16;14(1):47. doi: 10.1186/s12977-017-0370-5.
Characterization of myeloid cell populations in human testes collected after sex reassignment surgery.
Oct 11, 2017
Ponte R, Dupuy F, Brimo F, Mehraj V, Brassard P, Belanger M, Yurchenko E, Ali Jenabian M, Bernard NF, Routy JP, for the ORCHID study group. Journal of Reproductive Immunology. (2018) 16-24. doi: 10.1016/j.jri.2017.10.043
HIV-1 and HIV-Tat inhibit LPS-induced IL-27 production in human macrophages by distinct intracellular signaling pathway.
Jul 11, 2017
Gajanayaka N, O’Hara S, Konarski Y, Fernandes J, Muthumani K, Kozlowski M, Angel JB, Kumar A. J Leukoc Biol. 2017 Sep;102(3):925-939. doi: 10.1189/jlb.4A0716-332RR. Epub 2017 Jul 11.
Host MicroRNAs-221 and -222 Inhibit HIV-1 Entry in Macrophages by Targeting the CD4 Viral Receptor.
Oct 3, 2017
Lodge R, Ferreira Barbosa JA, Lombard-Vadnais F, Gilmore JC, Deshiere A, Gosselin A, Wiche Salinas TR, Bego MG, Power C, Routy JP, Ancuta P, Tremblay MJ, Cohen ÉA. Cell Rep. doi: 10.1016/j.celrep.2017.09.030.
The evaluation of risk-benefit ratio for gut tissue sampling in HIV cure research.
Oct 1, 2017
The Croton megalobotrys Müll Arg. traditional medicine in HIV/AIDS management: Documentation of patient use, in vitro activation of latent HIV-1 provirus, and isolation of active phorbol esters.
Sept 29, 2017
Tietjen I, Ngwenya BN, Fotso G, Williams DE, Simonambango S, Ngadjui BT, Andersen RJ, Brockman MA, Brumme ZL,Andrae-Marobela K. J Ethnopharmacol. 29;211:267-277. doi: 10.1016/j.jep.2017.09.038. [Epub ahead of print]
Potential contribution of gut microbiota and systemic inflammation on HIV vaccine effectiveness and vaccine design.
Sept 12, 2017
Routy JP and Mehraj V. AIDS Res Ther 2017. DOI 10.1186/s12981-017-0164-9
Multiparametric characterization of rare HIV-infected cells using an RNA-flow FISH technique.
Sept 7, 2017
Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Massanella M, Brassard N, Alsahafi N, Routy JP, Finzi A, Chomont N,Kaufmann D. Nat Protocol. doi: 10.1038/nprot.2017.079.
HIV-1 selectively targets gut-homing CCR6+CD4+ T-cells via mTOR-dependent mechanisms.
Aug 3, 2017
Planas D, Zhang Y, Monteiro P, Goulet JP, Gosselin A, Grandvaux N, Hope TJ, Fassati A, Routy JP, Ancuta P. JCI Insight. doi: 10.1172 /jci.insight.93230.
Impairment of the type I interferon response by HIV-1: Potential targets for HIV eradication.
Apr 24, 2017
Sandstrom TS, Ranganath N, Angel JB. Cytokine Growth Factor Rev. 37:1-16. doi: 10.1016/j.cytogfr.2017.04.004. Epub 2017 Apr 24.
HIV-1 Vpu downmodulates ICAM-1 expression resulting in decreased killing of infected CD4+ T cells by NK cells.
Mar 29, 2017
Sugden SM, Pham TN, Cohen EA. Journal of virology, 91(8): e02442-16.
CD4 T follicular helper cells and HIV infection: Friends or enemies?
Feb 20, 2017
Moukambi F, Rodrigues V, Fortier Y, Rabezanahary H, Borde C, Krust B, Andreani G, Silvestre R, Petrovas C, Laforge M, Estaquier J. Frontiers in immunology, 8:135.​​
HIV persists in CCR6+CD4+ T-cells from colon and blood during antiretroviral therapy.
Jan 2, 2017
Gosselin A, Wiche Salinas TR, Planas D, Wacleche VS, Zhang Y, Fromentin R, Chomont N, Cohen EA, Shacklett B, Mehraj V, Ghali MP, Routy JP, Ancuta P. AIDS2017, 31(1): 35-48.​​
Immune tolerance properties of the testicular tissue as a viral sanctuary site in ART-treated HIV-infected adults.
Nov 28, 2016
Jenabian MA, Costiniuk CT, Mehraj V, Ghazawi FM, Fromentin R, Brousseau J, Brassard P, Belanger M, Ancuta P, Bendayan R,Chomont N, Routy JP; for the Orchid study group. AIDS, 30(18): 2777-2786.​
Enhancing virion tethering by BST2 sensitizes productively and latently HIV-infected T cells to ADCC mediated by broadly neutralizing antibodies.
Nov 17, 2016
Pham TN, Lukhele S, Dallaire F, Perron G, Cohen EA. Scientific reports, 6: 37225.​
Differential control of BST2 restriction and plasmacytoid dendritic cell antiviral response by antagonists encoded by HIV-1 group M and O strains.
Oct 28, 2016
Bego MG, Cong L, Mack K, Kirchhoff F, Cohen EA. Journal of virology 2016, 90(22): 10236-10246.
Type I interferon responses are impaired in latently HIV infected cells.
Sept 9, 2016
Ranganath N, Sandstrom TS, Fadel S, Cote SC, Angel JB. Retrovirology 2016, 13(1): 66.
Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals.
Aug 18, 2016
Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Charlebois R, Massanella M, Brassard N, Alsahafi N, Delgado G-G,Routy JP, Walker BD, Finzi A, Chomont N, Kaufmann DE. Cell Host Microbe. 2016 Sep 14;20(3):368-380. doi: 10.1016/j.chom.2016.07.015. Epub 2016 Aug 18.
Kynurenine Reduces Memory CD4 T-Cell Survival by Interfering with Interleukin-2 Signaling Early during HIV-1 Infection.
Aug 12, 2016
Dagenais-Lussier X, Aounallah M, Mehraj V, El-Far M, Tremblay C, Sekaly RP, Routy JP, van Grevenynghe J; for the Montreal Primary Infection Study Group. Journal of virology, 90(17): 7967-7979