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Publications

2024

2023

Identifying physiological tissue niches that support the HIV reservoir in T cells.

31 octobre 2023

Ikeogu N, Ajibola O, Zayats R, Murooka TT

Early ART reduces viral seeding and innate immunity in liver and lungs of SIV-infected macaques.

24 juillet 2023

Clain JA, Rabezanahary H, Racine G, Boutrais S, Soudaramourty C, Beauparlant CJ, Jenabian M, Droit A, Ancuta P, Zghidi-Abouzid O, Estaquier J.

Generation of functional human T cell development in NOD/SCID/IL2rγnull humanized mice without using fetal tissue: Application as a model of HIV infection and persistence. 

14 février 2023

Colas C, Volodina O, Béland K, Pham, TNQ, Li Y, Dallaire F, Soulard C, Lemieux W, Colamartino ABL, Tremblay-Laganière C, Dicaire R, Guimond J, Vobecky S, Poirier N, Patey N, Cohen EA, Haddad E

2022

Targeting Th17 cells in HIV-1 remission / cure interventions. Trends in Immunology.

juillet 2022

Fert A, Marchand LR, Wiche Salinas TR, Ancuta P

Bryostatin-1 Decreases HIV-1 Infection and Viral Production in
Human Primary Macrophages.

février 2022

Hany L , Turmel M,  Barat C ,  Ouellet M , Tremblay MJ

T cell migration potentiates HIV infection by
enhancing viral fusion and integration.

février 2022

Lopex P, Ajibola O, Pagiluzza A, Zayats R, Hon Koh W, Herschhorn A, Chomont N, Murooka T

2021

Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth

novembre 2021

Salinas TRW, Zhang Y, Sarnello D, Zhyvoloup A, Raymond Marchanda L, Planas D, Lodha M, Chatterjee D, Karwacz K, Oxenford S, Routy JP, Madsen H, Ancuta P, and Fassati A. PNAS

Peculiar Phenotypic and Cytotoxic Features of Pulmonary Mucosal CD8 T Cells in People Living with HIV Receiving Long-Term Antiretroviral Therapy

mars 2021

Planas D, Pagliuzza A, Ponte R, Fert A, Marchand L.R, Massanella M, Gosselin A, Mehraj V, Dupuy F.P, Isnard S, Goulet J-P, Lesage S, , Ghali M.P, Angel J, Chomont N, Routy J-P, Ancuta P. EBioMedicine.

Beyond the Absence of CD4 T-Cell Count: A Novel Genetic CD4 T-Cell Deficiency Disorder With a Contingency Plan

24 février 2021

Routy J-P, Isnard S. J Infect Dis.

Differences in HIV burden in the inflamed and non-inflamed colon from a person living with HIV and ulcerative colitis

15 février 2021

Peng X, Isnard S, Lin J, Fombuena B, Bessissow T, Chomont N, Routy J-P. J Virus Erad.

2020

Peculiar Phenotypic and Cytotoxic Features of Pulmonary Mucosal CD8 T Cells in People Living with HIV Receiving Long-Term Antiretroviral Therapy

14 décembre 2020

Meziane O, Alexandrova Y, Olivenstein R, Dupuy FP, Salahuddin S, Thomson E, Orlova M, Schurr E, Ancuta P, Durand M, Chomont N, Estaquier J, Bernard NF, Costiniuk CT, Jenabian M-A. J Immunol. 

Early Antiretroviral Therapy Prevents Viral Infection of Monocytes and Inflammation in Simian Immunodeficiency Virus-Infected Rhesus Macaques

22 octobre 2020

Rabezanahary H, Clain J, Racine G, Andreani G, Benmadid-Laktout G, Borde C, Mammano F, Mesplèdes T, Ancuta P, Zghidi-Abouzid O, Estaquier J. J Virol.

Pharmacological Inhibition of PPARy Boosts HIV Reactivation and Th17 Effector Functions, While Preventing Progeny Virion Release and de novo Infection

30 septembre 2020

Planas D, Fert A, Zhang Y, Goulet J-P, Richard J, Finzi A, Julia Ruiz MJ, Marchand LR, Chatterjee D, Chen H, Raul Wiche Salinas T, Gosselin A, Cohen EA, Routy J-P, Chomont N, Ancuta P. Pathogen Immun.

Interleukin-1β Triggers p53-Mediated Downmodulation of CCR5 and HIV-1 Entry in Macrophages through MicroRNAs 103 and 107

29 septembre 2020

Lodge R, Bellini N, Laporte M, Salahuddin S, Routy J-P, Ancuta P, Costiniuk CT, Jenabian M-A,Cohen EA. mBio

HIV enters deep sleep in people who naturally control the virus 

septembre 2020

Chomont N. Nature

Distinct viral reservoirs in individuals with spontaneous control of HIV-1

septembre 2020

Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont N, Bar KJ, Yu XG, Lichterfeld M, Alcami J, Hazuda D, Bushman F, Siliciano JD, Betts MR,Spivak AM, Planelles V, Hahn BH, Smith DM, Ho Y, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJ, Kostman J, Mounzer K, Caskey M, Fox L, Frank I,Riley JL, Tebas P, Montaner LJ. Nature Med.

Recommendations for measuring HIV reservoir size in cure-directed clinical trials

7 septembre 2020

Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont N, Bar KJ, Yu XG, Lichterfeld M, Alcami J, Hazuda D, Bushman F, Siliciano JD, Betts MR,Spivak AM, Planelles V, Hahn BH, Smith DM, Ho Y, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJ, Kostman J, Mounzer K, Caskey M, Fox L, Frank I,Riley JL, Tebas P, Montaner LJ. Nature Med.

Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART

14 août 2020

Gantner P, Pagliuzza A, Pardons M, Ramgopal M, Routy JP, Fromentin R and Chomont N. Nature Communications

Improving HIV Outgrowth by Optimizing Cell-Culture Conditions and Supplementing With all-trans Retinoic Acid.

15 mai 2020

Zhang Y, Planas D, Marchand LR, Massanella M, Chen H, Wacleche VS, Gosselin A, Goulet J-P, Filion M, Routy J-P, Chomont N and Ancuta P. Frontiers in Microbiology.

2019

Despite early antiretroviral therapy effector memory and follicular helper CD4 T cells are major reservoirs in visceral lymphoid tissues of SIV-infected macaques.

13 novembre 2019

Rabezanahary H, Moukambi F, Palesch D, Clain J, Racine G, Andreani G, Benmadid-Laktout G, Zghidi-Abouzid O, Soundaramourty C, Tremblay C, Silvestri G, Estaquier J. Mucosal Immunol

Differential Dynamics of Regulatory T-Cell and Th17 Cell Balance in Mesenteric Lymph Nodes and Blood following Early Antiretroviral Initiation during Acute Simian Immunodeficiency Virus Infection.

12 septembre 2019

Yero A, Farnos O, Rabezanahary H, Racine G, Estaquier J, Jenabian MA. J. Virology

HIV Infection Stabilizes Macrophage-T Cell Interactions To Promote Cell-Cell HIV Spread.

28 août 2019

Lopez P, Koh WH, Hnatiuk R, Murooka TT. J. Virology

HIV diversity and genetic compartmentalization in blood and testes during suppressive antiretroviral therapy.

12 juin 2019

Miller RL, Ponte R, Jones BR, Kinloch NN, Omondi FH, Jenabian MA, Dupuy FP, Fromentin R, Brassard P, Mehraj V, Chomont N, Poon AFY, Joy JB, Brumme Z, Routy JP; ORCHID study group. J. Virology

Expression of MDM2 in Macrophages Promotes the Early Postentry Steps of HIV-1 Infection through Inhibition of p53.

21 mars 2019

Breton Y, Desrosiers V, Ouellet M, Deshiere A, Torresilla C, Cohen ÉA, Tremblay MJ. J. Virology

HIV-1 is rarely detected in blood and colon myeloid cells during viral-suppressive antiretroviral therapy.

11 mars 2019

Cattin A, Salinas TRW, Gosselin A, Planas D, Shacklett B, Cohen EA, Ghali MP, Routy JP, Ancuta P. AIDS

Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection.

27 février 2019

Pardons M, Baxter AE, Massanella M, Pagliuzza A, Fromentin R, Dufour C, Leyre L, Routy JP, Kaufmann DE, Chomont N. PLoS Pathogen.

PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals.

18 février 2019

Fromentin R, DaFonseca S, Costiniuk CT, El-Far M, Procopio FA, Hecht FM, Hoh R, Deeks SG, Hazuda DJ6, Lewin SR, Routy JP, Sékaly RP, Chomont N. Nature Communications.

Host mRNA decay proteins influence HIV-1 replication and viral gene expression in primary monocyte-derived macrophages.

7 février 2019

Shringar Rao, Raquel Amorim, Meijuan Niu, Yann Breton, Michel J. Tremblay and Andrew J. Mouland. Retrovirology.

Genetic complexity in the replication-competent latent HIV reservoir increases with untreated infection duration in infected youth.

1 février 2019

Brumme ZL, Sudderuddin H, Ziemniak C, Luzuriaga K, Jones BR, Joy JB, Cunningham CK, Greenough T, Persaud D. AIDS

Medical Assistance in Death as a Unique Opportunity to Advance HIV Cure Research.

31 janvier 2019

Sandstrom TS, Burke Schinkel SC, Angel JB. Clin Infect Dis.

HIV-1 Balances the Fitness Costs and Benefits of Disrupting the Host Cell Actin Cytoskeleton Early after Mucosal Transmission.

19 janvier 2019

Usmani SM, Murooka TT, Deruaz M, Koh WH, Sharaf RR, Di Pilato M, Power KA, Lopez P, Hnatiuk R, Vrbanac VD, Tager AM, Allen TM, Luster AD, Mempel TR. Cell Host Microbe.

HIV subtype and Nef-mediated immune evasion function correlate with viral reservoir size in early-treated individuals.

2 janvier 2019

Omondi FH, Chandrarathna S, Mujib S, Brumme CJ, Jin SW, Sudderuddin H, Miller R, Rahimi A, Laeyendecker O, Bonner P, Yue FY, Benko E, Kovacs CM, Brockman MA, Ostrowski M, Brumme ZL. J. Virology.

2018

Implications of HIV-1 Nef for "Shock and Kill" Strategies to Eliminate Latent Viral Reservoirs.

30 novembre 2018

Kuang XT1, Brockman MA. Viruses.

Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants

27 novembre 2018

Ogunshola F, Anmole G, Miller R, Goering E, Nkosi T, Muema D, Mann J, Ismail N, Chopera D, Ndung’u T, Brockman M & Ndhlovu Z. Nature Communications. 

HIV Cure Research: An example of successful advocacy by scientists for science 

3 novembre, 2018

Angel, JB. Clint Invest. Med. 

The RNA surveillance protein UPF1, UPF2 and SMG6 affects HIV-1 reactivation at post-transcriptional level.

28 juin 2018

Rao S, Amorin R, Niu M, Temzi A, Mouland A.  Retrovirology

The RNA surveillance protein UPF1, UPF2 and SMG6 affects HIV-1 reactivation at post-transcriptional level.

28 juin 2018

Rao S, Amorin R, Niu M, Temzi A, Mouland A.  Retrovirology

Identification of Novel HIV-1 Latency-Reversing Agents from a Library of Marine Natural Products.

27 juin 2018

Richard K, Williams DE, de Silva ED, Brockman MA, Brumme ZL, Andersen RJ, Tietjen I. Viruses

Use of (1→3)-β-D-Glucan for diagnosis and management of invasive mycoses in HIV-infected patients.

31 mai 2018

Farhour Z, Mehraj V, Chen J, Ramendra R, Lu H, Routy JP.  Mycoses. 2018 May 31;. [Epub ahead of print]

ADAR1 and PKR, interferon stimulated genes with clashing effects on HIV-1 replication. 

26 mars 2018

Radetskyy R, Daher A, Gatignol A. Cytokine Growth Factor Rev.  pii: S1359-6101(18)30032-7. doi: 10.1016/j.cytogfr.2018.03.007. [Epub ahead of print]

cIAP1/2-TRAF2-SHP-1-Src-MyD88 Complex Regulates Lipopolysaccharide-Induced IL-27 Production through NF-κB Activation in Human Macrophages.

1 mars 2018

Busca A,, Konarski Y, Gajanayaka N, O'Hara S, Angel J, Kozlowski M, Kumar A. J Immunol

Inhibition of NF-κB-dependent HIV-1 replication by the marine natural product bengamide A.

15 avril, 2018

Tietjen I, Williams DE, Read S, Kuang XT, Mwimanzi P, Wilhelm E, Markle T, Kinloch NN, Naphen CN, Tenney K, Mesplède T, Wainberg MA, Crews P, Bell B5, Andersen RJ, Brumme ZL, Brockman MA. Antiviral Res. 152:94-103. doi: 10.1016/j.antiviral.

Socio-economic status and time trends associated with early ART initiation following primary HIV infection in Montreal, Canada: 1996 to 2015.

6 fevrier 2018

Mehraj V, Cox J, Lebouché B, Costiniuk C, Cao W, Li T, Ponte R, Thomas R, Szabo J, Baril JG, Trottier B, Côté P, LeBlanc R, Bruneau J, Tremblay C, Routy JP; Montreal Primary HIV-Infection Study Group.  J Int AIDS Soc. 2018 Feb;21(2). doi: 10.1002/jia2.25034.

The Biology of Monocytes and Dendritic Cells: Contribution to HIV Pathogenesis. 

6 fevrier, 2018

Wacleche VS, Tremblay CL, Routy JP, Ancuta P. Viruses. 10(2). pii: E65. doi: 10.3390/v10020065.

cIAP1/2-TRAF2-SHP-1-Src-MyD88 Complex Regulates Lipopolysaccharide-Induced IL-27 Production through NF-κB Activation in Human Macrophages. 

22 Janvier, 2018

Busca A, Konarski Y, Gajanayaka N, O'Hara S, Angel J, Kozlowski M, Kumar A.  J Immunol.pii: ji1700199. doi: 10.4049/jimmunol.1700199. [Epub ahead of print]

Inducible HIV RNA transcription assays to measure HIV persistence: pros and cons of a compromise. 

17 Janvier, 2018

Plantin J, Massanella M, Chomont N. Retrovirology.15(1):9. doi: 10.1186/s12977-017-0385-y.

Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling.

16 Janvier, 2018

Wong RW, Lingwood CA, Ostrowski MA, Cabral T, Cochrane A.  Sci Rep. 8(1):850. doi: 10.1038/s41598-018-19298-x.

2017

Regulation of CD4 Receptor and HIV-1 Entry by MicroRNAs-221 and -222 during Differentiation of THP-1 Cells.

30 Décembre, 2017

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Lodge R, Gilmore JC, Ferreira Barbosa JA, Lombard-Vadnais F, Cohen ÉA. Viruses. 10(1). pii: E13. doi: 10.3390/v10010013.

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Xenobiotic Nuclear Receptors Pregnane X Receptor and Constitutive Androstane Receptor Regulate Antiretroviral Drug Efflux Transporters at the Blood-Testis Barrier.

Décembre 2017

Whyte-Allman SK, Hoque MT, Jenabian MA, Routy JP, Bendayan R

Contrasting effect of the latency-reversing agents bryostatin-1 and JQ1 on astrocyte-mediated neuroinflammation and brain neutrophil invasion.

11 Décembre 2017

Proust A, Barat C, Leboeuf M, Drouin J, Tremblay MJ. J Neuroinflammation. 2017 Dec 11;14(1):242. doi: 10.1186/s12974-017-1019-y.

The oncolytic virus, MG1, targets and eliminates latently HIV-1-infected cells: implications for an HIV cure.

8 Décembre 2017

Ranganath N, Sandstrom TS, Burke Schinkel SC, Côté SC, Angel JB. The Journal of Infectious Diseases.

Managing Expectations of an HIV Cure: What Should We Expect?

22 Nov 2017

Reinhard, RJ.  AIDS Res Hum Retroviruses. doi: 10.1089/AID.2017.0247. [Epub ahead of print]

HIV-1 NC-induced stress granule assembly and translation arrest are inhibited by the dsRNA binding protein Staufen1.

10 Nov 2017

Rao S, Cinti A, Temzi A, Amorim R, You JC, Mouland AJ. HIV-1 NC-induced stress granule assembly and translation arrest are inhibited by the dsRNA binding protein Staufen1. RNA. 2017 Nov 10. pii: rna.064618.117. doi: 10.1261/rna.064618.117. [Epub ahead of print]

Very early antiretroviral therapy permits CD8 T cells to keep HIV reservoirs at bay.

5 Nov 2017

Routy JP, Mehraj V. Ann Transl Med. 2017 Nov;5(21):434. doi: 10.21037/atm.2017.08.38.

The Interferon-induced Protein Kinase R: the base of a riboprotein scaffolding regulating the Human Immunodeficiency Virus.

Nov 2017

Daher A, Labbé RP, Radetskyy R, Gatignol A. Virologie. 2017. 21:211-224