CanCURE Principal Investigator Dr. Andrew Mouland, from the Lady Davis Institute at the Jewish General Hospital in Montréal, has published a new scientific article on HIV-1 in Nature Communications. His team has discovered that HIV-1 is capable of resisting against stress granules by blocking the cell’s ability to assemble them in its effort to fight off the virus. Stress granules are clusters of RNA and proteins that cells assemble as a protective measure against environmental stresses and viral infections. This important finding constitutes an unexpected facet of how HIV-1 commandeers the host cell’s antiviral stress response.
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Valiente-Echeverria F et al. Nat. Commun. 2014