LILAC pilot study: Effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy
March 2021
Planas D, Pagliuzza A, Ponte R, Fert A, Marchand L.R, Massanella M, Gosselin A, Mehraj V, Dupuy F.P, Isnard S, Goulet J-P, Lesage S, , Ghali M.P, Angel J, Chomont N, Routy J-P, Ancuta P. EBioMedicine.
February 24 2021
February 15 2021
Peculiar Phenotypic and Cytotoxic Features of Pulmonary Mucosal CD8 T Cells in People Living with HIV Receiving Long-Term Antiretroviral Therapy
December 14 2020
HIV Infection and Persistence in Pulmonary Mucosal Double Negative T Cells In Vivo
November 23 2020
Early Antiretroviral Therapy Prevents Viral Infection of Monocytes and Inflammation in Simian Immunodeficiency Virus-Infected Rhesus Macaques
October 27 2020
Pharmacological Inhibition of PPARy Boosts HIV Reactivation and Th17 Effector Functions, While Preventing Progeny Virion Release and de novo Infection
September 30 2020
Interleukin-1β Triggers p53-Mediated Downmodulation of CCR5 and HIV-1 Entry in Macrophages through MicroRNAs 103 and 107
September 29 2020
HIV enters deep sleep in people who naturally control the virus
September 2020
Distinct viral reservoirs in individuals with spontaneous control of HIV-1
September 2020
Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont N, Bar KJ, Yu XG, Lichterfeld M, Alcami J, Hazuda D, Bushman F, Siliciano JD, Betts MR,Spivak AM, Planelles V, Hahn BH, Smith DM, Ho Y, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJ, Kostman J, Mounzer K, Caskey M, Fox L, Frank I,Riley JL, Tebas P, Montaner LJ. Nature Med.
September 7, 2020
Recommendations for measuring HIV reservoir size in cure-directed clinical trials
Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont N, Bar KJ, Yu XG, Lichterfeld M, Alcami J, Hazuda D, Bushman F, Siliciano JD, Betts MR,Spivak AM, Planelles V, Hahn BH, Smith DM, Ho Y, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJ, Kostman J, Mounzer K, Caskey M, Fox L, Frank I,Riley JL, Tebas P, Montaner LJ. Nature Med.
HIV-Captured DCs Regulate T Cell Migration and Cell-Cell Contact Dynamics to Enhance Viral Spread.
Hon Koh W, Lopez P, Ajibola O, Parvarchian R, Mohammad U, Hnatiuk R, Kindrachuk J, Murooka TT. iScienc.
August 21, 2020
Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART
Gantner P, Pagliuzza A, Pardons M, Ramgopal M, Routy JP, Fromentin R and Chomont N. Nature Communications
August 14, 2020
May 15, 2020
Improving HIV Outgrowth by Optimizing Cell-Culture Conditions and Supplementing With all-trans Retinoic Acid.
Zhang Y, Planas D, Marchand LR, Massanella M, Chen H, Wacleche VS, Gosselin A, Goulet J-P, Filion M, Routy J-P, Chomont N and Ancuta P. Frontiers in Microbiology
The Bacterium Akkermansia muciniphila: A Sentinel for Gut Permeability and Its Relevance to HIV-Related Inflammation.
Ouyang J, Lin J, Isnard S, Fombuena B, Peng X, Marette A, Routy B, Messaoudene M, Chen Y, Routy J-P. Frontiers in Immunology.
April 9, 2020
The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies.
Cohn LB, Chomont N, Deeks SG. Cell Host Microbe.
April 8, 2020
Metformin effect on gut microbiota: insights for HIV-related inflammation
Ouyang J, Isnard S, Lin J, Fombuena B, Marette A, Routy B, Chen Y, Routy JP. AIDS research and Therapy.
March 10, 2020
Plasma Levels of C-Type Lectin REG3α and Gut Damage in People With Human Immunodeficiency Virus
January 1, 2020
Despite early antiretroviral therapy effector memory and follicular helper CD4 T cells are major reservoirs in visceral lymphoid tissues of SIV-infected macaques.
November 14th, 2019
Differential Dynamics of Regulatory T-Cell and Th17 Cell Balance in Mesenteric Lymph Nodes and Blood following Early Antiretroviral Initiation during Acute Simian Immunodeficiency Virus Infection.
Yero A, Farnos O, Rabezanahary H, Racine G, Estaquier J, Jenabian MA. J. Virology
September 12th, 2019
HIV Infection Stabilizes Macrophage-T Cell Interactions To Promote Cell-Cell HIV Spread.
Lopez P, Koh WH, Hnatiuk R, Murooka TT. J. Virology
August 28th, 2019
HIV diversity and genetic compartmentalization in blood and testes during suppressive antiretroviral therapy.
Miller RL, Ponte R, Jones BR, Kinloch NN, Omondi FH, Jenabian MA, Dupuy FP, Fromentin R, Brassard P, Mehraj V, Chomont N, Poon AFY, Joy JB, Brumme Z, Routy JP; ORCHID study group. J. Virology
June 12th, 2019
Expression of MDM2 in Macrophages Promotes the Early Postentry Steps of HIV-1 Infection through Inhibition of p53.
March 21st, 2019
Breton Y, Desrosiers V, Ouellet M, Deshiere A, Torresilla C, Cohen ÉA, Tremblay MJ. J. Virology
HIV-1 is rarely detected in blood and colon myeloid cells during viral-suppressive antiretroviral therapy.
March 11th, 2019
Cattin A, Salinas TRW, Gosselin A, Planas D, Shacklett B, Cohen ÉA, Ghali MP, Routy JP, Ancuta P. AIDS
Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection.
February 27th, 2019
Pardons M, Baxter AE, Massanella M, Pagliuzza A, Fromentin R, Dufour C, Leyre L, Routy JP, Kaufmann DE, Chomont N. PLoS Pathogen.
PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals.
February 18th, 2019
Fromentin R, DaFonseca S, Costiniuk CT, El-Far M, Procopio FA, Hecht FM, Hoh R, Deeks SG, Hazuda DJ6, Lewin SR, Routy JP, Sékaly RP, Chomont N. Nature Communications.
Genetic complexity in the replication-competent latent HIV reservoir increases with untreated infection duration in infected youth.
February 1st, 2019
Medical Assistance in Death as a Unique Opportunity to Advance HIV Cure Research.
January 31rst, 2019
HIV-1 Balances the Fitness Costs and Benefits of Disrupting the Host Cell Actin Cytoskeleton Early after Mucosal Transmission.
January 9th, 2019
HIV subtype and Nef-mediated immune evasion function correlate with viral reservoir size in early-treated individuals.
January 2nd, 2019
Omondi FH, Chandrarathna S, Mujib S, Brumme CJ, Jin SW, Sudderuddin H, Miller R, Rahimi A, Laeyendecker O, Bonner P, Yue FY, Benko E, Kovacs CM, Brockman MA, Ostrowski M, Brumme ZL. J. Virology
Implications of HIV-1 Nef for "Shock and Kill" Strategies to Eliminate Latent Viral Reservoirs.
November 30th, 2018
Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants
November 27th, 2018
Phylogenetic approach to recover integration dates of latent HIV sequences within-host
September 5th, 2018
Bradley R. Jones, Natalie N. Kinloch, Joshua Horacsek, Bruce Ganase, Marianne Harris, P. Richard Harrigan, R. Brad Jones, Mark A. Brockman, Jeffrey B. Joy, Art F. Y. Poon, and Zabrina L. Brumme. PNAS
Socio-economic status and time trends associated with early ART initiation following primary HIV infection in Montreal, Canada: 1996 to 2015.
Feb 6, 2018
Mehraj V, Cox J, Lebouché B, Costiniuk C, Cao W, Li T, Ponte R, Thomas R, Szabo J, Baril JG, Trottier B, Côté P, LeBlanc R, Bruneau J, Tremblay C, Routy JP; Montreal Primary HIV-Infection Study Group. J Int AIDS Soc. 2018 Feb;21(2). doi: 10.1002/jia2.25034.
Inhibition of NF-κB-dependent HIV-1 replication by the marine natural product bengamide A.
April 15, 2018
Tietjen I, Williams DE, Read S, Kuang XT, Mwimanzi P, Wilhelm E, Markle T, Kinloch NN, Naphen CN, Tenney K, Mesplède T, Wainberg MA, Crews P, Bell B5, Andersen RJ, Brumme ZL, Brockman MA. Antiviral Res. 152:94-103. doi: 10.1016/j.antiviral.
ADAR1 and PKR, interferon stimulated genes with clashing effects on HIV-1 replication.
March 26, 2018
Radetskyy R, Daher A, Gatignol A. Cytokine Growth Factor Rev. pii: S1359-6101(18)30032-7. doi: 10.1016/j.cytogfr.2018.03.007. [Epub ahead of print]
Use of (1→3)-β-D-Glucan for diagnosis and management of invasive mycoses in HIV-infected patients.
May 31st, 2018
Farhour Z, Mehraj V, Chen J, Ramendra R, Lu H, Routy JP. Mycoses. 2018 May 31;. [Epub ahead of print]
Contrasting effect of the latency-reversing agents bryostatin-1 and JQ1 on astrocyte-mediated neuroinflammation and brain neutrophil invasion.
Dec 11, 2017
Proust A, Barat C, Leboeuf M, Drouin J, Tremblay MJ. J Neuroinflammation. 2017 Dec 11;14(1):242. doi: 10.1186/s12974-017-1019-y.
The Biology of Monocytes and Dendritic Cells: Contribution to HIV Pathogenesis.
Feb 6, 2018
Wacleche VS, Tremblay CL, Routy JP, Ancuta P. Viruses. 10(2). pii: E65. doi: 10.3390/v10020065.
Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling.
Jan 16, 2018
Wong RW, Lingwood CA, Ostrowski MA, Cabral T, Cochrane A. Sci Rep. 8(1):850. doi: 10.1038/s41598-018-19298-x.
cIAP1/2-TRAF2-SHP-1-Src-MyD88 Complex Regulates Lipopolysaccharide-Induced IL-27 Production through NF-κB Activation in Human Macrophages.
Jan 22, 2018
Busca A, Konarski Y, Gajanayaka N, O'Hara S, Angel J, Kozlowski M, Kumar A. J Immunol.pii: ji1700199. doi: 10.4049/jimmunol.1700199. [Epub ahead of print]
Inducible HIV RNA transcription assays to measure HIV persistence: pros and cons of a compromise.
Jan 17, 2018
Plantin J, Massanella M, Chomont N. Retrovirology.15(1):9. doi: 10.1186/s12977-017-0385-y.
The oncolytic virus, MG1, targets and eliminates latently HIV-1-infected cells: implications for an HIV cure.
Dec 8, 2017
Ranganath N, Sandstrom TS, Burke Schinkel SC, Côté SC, Angel JB. The Journal of Infectious Diseases.
Xenobiotic Nuclear Receptors Pregnane X Receptor and Constitutive Androstane Receptor Regulate Antiretroviral Drug Efflux Transporters at the Blood-Testis Barrier.
December, 2017
Managing Expectations of an HIV Cure: What Should We Expect?
Nov 22, 2017
Reinhard, RJ. AIDS Res Hum Retroviruses. doi: 10.1089/AID.2017.0247. [Epub ahead of print]
HIV-1 NC-induced stress granule assembly and translation arrest are inhibited by the dsRNA binding protein Staufen1.
Nov 10, 2017
Rao S, Cinti A, Temzi A, Amorim R, You JC, Mouland AJ. HIV-1 NC-induced stress granule assembly and translation arrest are inhibited by the dsRNA binding protein Staufen1. RNA. 2017 Nov 10. pii: rna.064618.117. doi: 10.1261/rna.064618.117. [Epub ahead of print]
Very early antiretroviral therapy permits CD8 T cells to keep HIV reservoirs at bay.
Nov 5, 2017
Routy JP, Mehraj V. Ann Transl Med. 2017 Nov;5(21):434. doi: 10.21037/atm.2017.08.38.
The Interferon-induced Protein Kinase R: the base of a riboprotein scaffolding regulating the Human Immunodeficiency Virus.
Nov 2017
The Th17 Lineage: From Barrier Surfaces homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis.
Oct 19, 2017
Sue Waclech V, Landay A, Routy JP, Ancuta P. Viruses. 19;9(10). pii: E303. doi: 10.3390/v9100303.
Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain.
Oct 16, 2017
Asahchop EL, Meziane O, Mamik MK, Chan WF, Branton WG, Resch L, Gill MJ, Haddad E, Guimond JV, Wainberg MA, Baker GB, Cohen EA, Power C. Retrovirology. 16;14(1):47. doi: 10.1186/s12977-017-0370-5.
Characterization of myeloid cell populations in human testes collected after sex reassignment surgery.
Oct 11, 2017
Ponte R, Dupuy F, Brimo F, Mehraj V, Brassard P, Belanger M, Yurchenko E, Ali Jenabian M, Bernard NF, Routy JP, for the ORCHID study group. Journal of Reproductive Immunology. (2018) 16-24. doi: 10.1016/j.jri.2017.10.043
Host MicroRNAs-221 and -222 Inhibit HIV-1 Entry in Macrophages by Targeting the CD4 Viral Receptor.
Oct 3, 2017
Lodge R, Ferreira Barbosa JA, Lombard-Vadnais F, Gilmore JC, Deshiere A, Gosselin A, Wiche Salinas TR, Bego MG, Power C, Routy JP, Ancuta P, Tremblay MJ, Cohen ÉA. Cell Rep. doi: 10.1016/j.celrep.2017.09.030.
The evaluation of risk-benefit ratio for gut tissue sampling in HIV cure research.
Oct 1, 2017
The Croton megalobotrys Müll Arg. traditional medicine in HIV/AIDS management: Documentation of patient use, in vitro activation of latent HIV-1 provirus, and isolation of active phorbol esters.
Sept 29, 2017
Tietjen I, Ngwenya BN, Fotso G, Williams DE, Simonambango S, Ngadjui BT, Andersen RJ, Brockman MA, Brumme ZL,Andrae-Marobela K. J Ethnopharmacol. 29;211:267-277. doi: 10.1016/j.jep.2017.09.038. [Epub ahead of print]
Antiviral Activity of Bictegravir and Cabotegravir Against Integrase Inhibitor Resistant SIVmac239 and HIV-1.
Sept 18, 2017
Hassounah SA, Alikhani A, Oliveira M, Bharaj S, Ibanescu RI, Osman N, Xu HT, Brenner BG, Mesplède T, Wainberg MA. Antimicrob Agents Chemorther, 18 sept 2017. doi: 10.1128/AAC.01695-17. [Epub ahead of print]
RNA flow cytometric FISH for investigations into HIV immunology, vaccination and cure strategies.
Sept 12, 2017
Baxter AE, Niessl J, Morou A, Kaufmann DE. AIDS Res Ther 2017 DOI 10.1186/s12981-017-0171-x
Potential contribution of gut microbiota and systemic inflammation on HIV vaccine effectiveness and vaccine design.
Sept 12, 2017
Routy JP and Mehraj V. AIDS Res Ther 2017. DOI 10.1186/s12981-017-0164-9
Multiparametric characterization of rare HIV-infected cells using an RNA-flow FISH technique.
Sept 7, 2017
Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Massanella M, Brassard N, Alsahafi N, Routy JP, Finzi A, Chomont N,Kaufmann D. Nat Protocol. doi: 10.1038/nprot.2017.079.
Pharmacologic HIV-1 Nef blockade promotes CD8 T cell–mediated elimination of latently HIV-1–infected cells in vitro.
Sept 7, 2017
Mujib S, Saiyed A, Fadel S, Bozorgzad A, Aidarus N, Yun Yue F, Benko E, Kovacs C, Emert-Sedlak LA, Smithgall TE, Ostrowski MA. JCI Insight. DOI: 10.1172/jci.insight.93684.
HIV-1 selectively targets gut-homing CCR6+CD4+ T-cells via mTOR-dependent mechanisms.
Aug 3, 2017
Planas D, Zhang Y, Monteiro P, Goulet JP, Gosselin A, Grandvaux N, Hope TJ, Fassati A, Routy JP, Ancuta P. JCI Insight. doi: 10.1172 /jci.insight.93230.
Comprehensive cross-clade characterization of antibody-mediated recognition, complement-mediated lysis and cell-mediated cytotoxicity of HIV-1 envelope specific antibodies towards the eradication of the HIV-1 reservoir.
Jul 27, 2017
Mujib S, Liu J, Rahman AKMN, Schwartz JA, Bonner P, Yue FY, Ostrowski MA. J Virol. 27;91(16). pii: e00634-17. doi: 10.1128/JVI.00634-17. Print 2017 Aug 15.
HIV-1 enhances mTORC1 activity and repositions lysosomes to the periphery by co-opting Rag GTPase.
Jul 14 2017
Cinti A, Le Sage V, Mirev MP, Valiente-Echeverria F, Crossie C, Miron MJ, Pante N, Oliver M, Mouland AJ. Scientific Reports. 7(1):5515.
Global mapping of the macrophage-HIV-1 transcriptome reveals that productive infection induces remodeling of host cell DNA and chromatin.
Jul 12 2017
Deshiere A, Joly-Beauparlant C, Breton Y, Ouellet M, Raymond F, Lodge R, Barat C, Roy M-A, Corbeil J, Tremblay MJ. Scientific Reports. 7(1):5238.
HIV-1 and HIV-Tat inhibit LPS-induced IL-27 production in human macrophages by distinct intracellular signaling pathway.
Jul 11, 2017
Gajanayaka N, O’Hara S, Konarski Y, Fernandes J, Muthumani K, Kozlowski M, Angel JB, Kumar A. J Leukoc Biol. 2017 Sep;102(3):925-939. doi: 10.1189/jlb.4A0716-332RR. Epub 2017 Jul 11.
Impairment of the type I interferon response by HIV-1: Potential targets for HIV eradication.
Apr 24, 2017
Sandstrom TS, Ranganath N, Angel JB. Cytokine Growth Factor Rev. 37:1-16. doi: 10.1016/j.cytogfr.2017.04.004. Epub 2017 Apr 24.
Tim-3 is a marker of plasmacytoid dendritic cell dysfunction during HIV infection and is associated with the recruitment of IRF7 and p85 into lysosomes and with the submembrane displacement of TLR9.
Mar 6, 2017
Schwartz JA, Clayton KL, Mujib S, Zhang H, Rahman AK, Liu J, Yue FY, Benko E, Kovacs C, Ostrowski MA. J Immunol. 2017 Apr 15;198(8):3181-3194. doi: 10.4049/jimmunol.1601298. Epub 2017 Mar 6.
HIV-1 Vpu downmodulates ICAM-1 expression resulting in decreased killing of infected CD4+ T cells by NK cells.
Mar 29, 2017
Sugden SM, Pham TN, Cohen EA. Journal of virology, 91(8): e02442-16.
CD4 T follicular helper cells and HIV infection: Friends or enemies?
Feb 20, 2017
Moukambi F, Rodrigues V, Fortier Y, Rabezanahary H, Borde C, Krust B, Andreani G, Silvestre R, Petrovas C, Laforge M, Estaquier J. Frontiers in immunology, 8:135.
HIV persists in CCR6+CD4+ T-cells from colon and blood during antiretroviral therapy.
Jan 2, 2017
Gosselin A, Wiche Salinas TR, Planas D, Wacleche VS, Zhang Y, Fromentin R, Chomont N, Cohen EA, Shacklett B, Mehraj V, Ghali MP, Routy JP, Ancuta P. AIDS2017, 31(1): 35-48.
Ebola virus VP35 blocks stress granule assembly.
Dec 23, 2016
Le Sage V, Cinti A, McCarthy S, Amorim R, Rao S, Daino GL, Tramontano E, Branch DR, Mouland AJ. Virology. 2017 Feb;502:73-83. doi: 10.1016/j.virol.2016.12.012. Epub 2016 Dec 23.
HIV-1 latency-reversing agents prostratin and bryostatin-1 induce blood-brain barrier disruption/inflammation and modulate leukocyte adhesion/transmigration.
Dec 19, 2016
Dental C, Proust A, Ouellet M, Barat C, Tremblay MJ. J Immunol. Feb 1;198(3):1229-1241. doi: 10.4049/jimmunol.1600742. Epub 2016 Dec 19.
Immune tolerance properties of the testicular tissue as a viral sanctuary site in ART-treated HIV-infected adults.
Nov 28, 2016
Jenabian MA, Costiniuk CT, Mehraj V, Ghazawi FM, Fromentin R, Brousseau J, Brassard P, Belanger M, Ancuta P, Bendayan R,Chomont N, Routy JP; for the Orchid study group. AIDS, 30(18): 2777-2786.
Enhancing virion tethering by BST2 sensitizes productively and latently HIV-infected T cells to ADCC mediated by broadly neutralizing antibodies.
Nov 17, 2016
Pham TN, Lukhele S, Dallaire F, Perron G, Cohen EA. Scientific reports, 6: 37225.
AMPK in Pathogens.
Nov 4, 2016
Mesquita I, Moreira D, Sampaio-Marques B, Laforge M, Cordeiro-da-Silva A, Ludovico P, Estaquier J, Silvestre R. Experientia Supplementum, 107: 287-323.
Differential control of BST2 restriction and plasmacytoid dendritic cell antiviral response by antagonists encoded by HIV-1 group M and O strains.
Oct 28, 2016
Bego MG, Cong L, Mack K, Kirchhoff F, Cohen EA. Journal of virology 2016, 90(22): 10236-10246.
Type I interferon responses are impaired in latently HIV infected cells.
Sept 9, 2016
Ranganath N, Sandstrom TS, Fadel S, Cote SC, Angel JB. Retrovirology 2016, 13(1): 66.
Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals.
Aug 18, 2016
Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Charlebois R, Massanella M, Brassard N, Alsahafi N, Delgado G-G,Routy JP, Walker BD, Finzi A, Chomont N, Kaufmann DE. Cell Host Microbe. 2016 Sep 14;20(3):368-380. doi: 10.1016/j.chom.2016.07.015. Epub 2016 Aug 18.
Kynurenine Reduces Memory CD4 T-Cell Survival by Interfering with Interleukin-2 Signaling Early during HIV-1 Infection.
Aug 12, 2016
Dagenais-Lussier X, Aounallah M, Mehraj V, El-Far M, Tremblay C, Sekaly RP, Routy JP, van Grevenynghe J; for the Montreal Primary Infection Study Group. Journal of virology, 90(17): 7967-7979
Role and modulation of drug transporters in HIV-1 therapy.
May 13, 2016
Alam C, Whyte-Allman SK, Omeragic A, Bendayan R. Adv Drug Deliv Rev. Aug 1;103:121-43. doi: 10.1016/j.addr.2016.05.001. Epub 2016 May 13.
Publications
Antiretroviral drug transporters and metabolic enzymes in human testicular tissue: potential contribution to HIV-1 sanctuary site.
April 13, 2016
Huang Y, Hoque MT, Jenabian MA, Vyboh K, Whyte SK, Sheehan NL, Brassard P, Belanger M, Chomont N, Fletcher CV, Routy JP, Bendayan R. J Antimicrob Chemother. 2016 Jul;71(7):1954-65. doi: 10.1093/jac/dkw046. Epub 2016 Apr 13.
The plasma levels of soluble ST2 as a marker of gut mucosal damage in early HIV infection.
June 19, 2016
Mehraj V, Jenabian MA, Ponte R, Lebouche B, Costiniuk C, Thomas R, Baril JG, Leblanc R, Cox J, Tremblay C, Routy JP, for the Primary HIV Infection and the Long-Term Non-Progressors Study Groups. AIDS 2016, 30(10): 1617-1627.
Adapting the stress response: viral subversion of the mTOR signaling pathway.
May 24, 2016
Le Sage V, Cinti A, Amorim R, Mouland AJ. Viruses 2016, 8(6): 152
Indoleamine 2,3-dioxygenase-expressing aortic plasmacytoid dendritic cells protect against atherosclerosis by induction of regulatory T cells.
May 10, 2016
Yun TJ, Lee JS, Machmach K, Shim D, Choi J, Wi YJ, Jang HS, Jung IH, Kim K, Yoon WK, Miah MA, Li B, Chang J, Bego MG, Pham TN, Loschko J, Fritz JH, Krug AB, Lee SP, Keler T, Guimond JV, Haddad E, Cohen EA, Sirois MG, El-Hamamsy I, Colonna M, Oh GT, Choi JH, Cheong C. Cell metabolism 2016, 23(5): 852-866.
HIV-1-mediated BAFF secretion in macrophages does not require endosomal TLRs, type-I IFN, and Nef, but depends on the cellular phenotype status.
Mar 28, 2017
Gomez AM, Ouellet M, Deshiere A, Breton Y, Tremblay MJ. Journal of immunology 2016, 196(9): 3806-3817.
Bacterial DNA protects monocytic cells against HIV-Vpr-induced mitochondrial membrane depolarization.
Mar 11, 2016
Saxena M, Busca A, Holcik M, Kumar A. Journal of immunology 2016, 196(9): 3754-3767.
Dendritic cell immunotherapy for HIV-1 infection using autologous HIV-1 RNA: a randomized, double-blind, placebo-controlled clinical trial.
May 1, 2016
Jacobson JM, Routy JP, Welles S, DeBenedette M, Tcherepanova I, Angel JB, Asmuth DM, Stein DK, Baril JG, McKellar M, Margolis DM, Trottier B, Wood K, Nicolette C. Journal of acquired immune deficiency syndromes 2016, 72(1): 31-38.
HIV-1 Gag blocks selenite-induced stress granule assembly by altering the mRNA cap-binding complex.
Mar 29, 2016
Cinti A, Le Sage V, Ghanem M, Mouland AJ. mBio 2016, 7(2):e00329-16.
Elevation and persistence of CD8 T-cells in HIV infection: the Achilles heel in the ART era.
Oct 3, 2017
Cao W, Mehraj V, Kaufmann DE, Li T, Routy JP. Journal of the International AIDS Society 2016, 19(1): 20697.
Reversing gut damage in HIV infection: using non-human primate models to instruct clinical research.
Jan 26, 2016
Ponte R, Mehraj V, Ghali P, Couedel-Courteille A, Cheynier R, Routy JP. EBioMedicine 2016, 4: 40-49.
Reversing gut damage in HIV infection: using non-human primate models to instruct clinical research.
Dec 2, 2015
Ponte R, Mehraj V, Ghali P, Couedel-Courteille A, Cheynier R, Routy JP. EBioMedicine 2016, 4: 40-49.
HIV immunotherapy comes of age: implications for prevention, treatment and cure.
Dec 2, 2015
Routy JP, Mehraj V, Cao W. Expert review of clinical immunology 2016, 12(2): 91-94.
Early initiation rather than prolonged duration of antiretroviral therapy in HIV infection contributes to the normalization of CD8+ T-cell counts.
Sept 8, 2015
Cao W, Mehraj V, Trottier B, Baril JG, Leblanc R, Lebouche B, Cox J, Tremblay C, Lu W, Singer J, Li T, Routy JP, and the Montreal Primary HIV infection Study Group. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2016, 62(2): 250-257.
Early loss of splenic Tfh cells in SIV-infected rhesus macaques.
Dec 7, 2015
Moukambi F, Rabezanahary H, Rodrigues V, Racine G, Robitaille L, Krust B, Andreani G, Soundaramourty C, Silvestre R, Laforge M, Estaquier J. PLoS pathogens 2015, 11(12): e1005287.
Differential evolution of a CXCR4-using HIV-1 strain in CCR5wt/wt and CCR5∆32/∆32 hosts revealed by longitudinal deep sequencing and phylogenetic reconstruction.
Dec 3, 2015
Le AQ, Taylor J, Dong W, McCloskey R, Woods C, Danroth R, Hayashi K, Milloy MJ, Poon AF, Brumme ZL. Scientific reports 2015, 5: 17607.
Characterization of the drug resistance profiles of integrase strand transfer inhibitors in simian immunodeficiency virus SIVmac239.
Sept 16, 2015
Hassounah SA, Liu Y, Quashie PK, Oliveira M, Moisi D, Brenner BG, Sandstrom PA, Mesplede T, Wainberg MA. Journal of virology, 89(23): 12002-12013.
A robust and scalable TCR-based reporter cell assay to measure HIV-1 Nef-mediated T cell immune evasion.
Aug 28, 2015
Anmole G, Kuang XT, Toyoda M, Martin E, Shahid A, Le AQ, Markle T, Baraki B, Jones RB, Ostrowski MA, Ueno T, Brumme ZL,Brockman MA. Journal of immunological methods 2015, 426: 104-113.
HIV-1 recruits UPF1 but excludes UPF2 to promote nucleocytoplasmic export of the genomic RNA.
Oct 20, 2015
Ajamian L, Abel K, Rao S, Vyboh K, Garcia-de-Gracia F, Soto-Rifo R, Kulozik AE, Gehring NH, Mouland AJ. Biomolecules, 5(4): 2808-2839.
Challenges and opportunities for T-cell-mediated strategies to eliminate HIV reservoirs.
2 oct 2015
Brockman MA, Jones RB, Brumme ZL. Frontiers in immunology 2015, 6:506.
Overcoming the challenge of diagnosis of early HIV infection: a stepping stone to optimal patient management.
Sept 11, 2015
Routy JP, Cao W, Mehraj V. Expert review of anti-infective therapy, 13(10): 1189-1193.
Proteomic analysis of HIV-1 Gag interacting partners using proximity-dependent biotinylation.
Sept 11, 2015
Le Sage V, Cinti A, Valiente-Echeverria F, Mouland AJ. Virology journal 2015, 12(1): 138.
Immunosuppressive tryptophan catabolism and gut mucosal dysfunction following early HIV infection.
Jan 23, 2015
Jenabian MA, El-Far M, Vyboh K, Kema I, Costiniuk CT, Thomas R, Baril JG, LeBlanc R, Kanagaratham C, Radzioch D, Allam O, Ahmad A, Lebouche B, Tremblay C, Ancuta P, Routy JP; for the Montreal Primary infection and Slow Progressor Study Groups. The Journal of infectious diseases 2015, 212:(3): 355-366.
Vpu exploits the cross-talk between BST2 and the ILT7 receptor to suppress anti-HIV-1 responses by plasmacytoid dendritic cells.
Jul 14, 2015
Bego MG, Côté E, Aschman N, Mercier J, Weissenhorn W, Cohen EA. PLoS pathogens 2015, 11(7): e1005024.
CD4:CD8 ratio as a frontier marker for clinical outcome, immune dysfunction and viral reservoir size in virologically suppressed HIV-positive patients.
Jun 29, 2015
Lu W, Mehraj V, Vyboh K, Cao W, Li T, Routy JP. Journal of the International AIDS Society, 18: 20052.
Clinical relevance of kynurenine pathway in HIV/AIDS: An immune checkpoint at the crossroads of metabolism and inflammation.
May 6, 2015
Routy JP, Mehraj V, Vyboh K, Cao W, Kema I, Jenabian MA. AIDS reviews, 17(2): 96-106.
Impaired Th17 polarization of phenotypically naive CD4+ T-cells during chronic HIV-1 infection and potential restoration with early ART.
Apr 30, 2015
DaFonseca S, Niessl J, Pouvreau S, Wacleche VS, Gosselin A, Cleret-Buhot A, Bernard N, Tremblay C, Jenabian MA, Routy JP,Ancuta P. Retrovirology 2015, 12(1): 38.
HIV-1-triggered release of type I IFN by plasmacytoid dendritic cells induces BAFF production in monocytes.
Mar 1, 2015
Gomez AM, Ouellet M, Tremblay MJ. Journal of immunology, 194(5): 2300-2308.
Elevated expression of LAG-3, but not PD-1, is associated with impaired iNKT cytokine production during chronic HIV-1 infection and treatment.
Feb 13, 2015
Juno JA, Stalker AT, Waruk JL, Oyugi J, Kimani M, Plummer FA, Kimani J, Fowke KR. Retrovirology2015, 12(1): 17.
PI3K/Akt regulates survival during differentiation of human macrophages by maintaining NF-kB-dependent expression of antiapoptotic Bcl-xL.
Sept 15, 2014
Busca A, Saxena M, Iqbal S, Angel J, Kumar A. Journal of leukocyte biology, 96(6): 1011-1022.
eEF2 and Ras-GAP SH3 domain-binding protein (G3BP1) modulate stress granule assembly during HIV-1 infection.
Sep 17, 2014
Valiente-Echeverría F, Melnychuk L, Vyboh K, Ajamian L, Gallouzi IE, Bernard N, Mouland AJ. Nature communications 2014, 5: 4819
Effect of HIV-1 integrase resistance mutations when introduced into SIVmac239 on susceptibility to integrase strand transfer inhibitors.
Sept 1, 2014
Hassounah SA, Mesplede T, Quashie PK, Oliveira M, Sandstrom PA, Wainberg MA. Journal of virology2014, 88(17): 9683-9692.
A conserved target site in HIV-1 Gag RNA is accessible to inhibition by both an HDV ribozyme and a short hairpin RNA.
Jul 29, 2014
Scarborough RJ, Levesque MV, Boudrias-Dalle E, Chute IC, Daniels SM, Ouellette RJ, Perreault JP, Gatignol A. Molecular therapy nucleic acids, 3: e178.
Flt3L dependence helps define an uncharacterized subset of murine cutaneous dendritic cells.
Nov 28, 2013
Mollah SA, Dobrin JS, Feder RE, Tse SW, Matos IG, Cheong C, Steinman RM, Anandasabapathy N. The Journal of investigative dermatology, 134(5): 1265-1275.
LILAC pilot study: Effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy
Planas D, Pagliuzza A, Ponte R, Fert A, Marchand L.R, Massanella M, Gosselin A, Mehraj V, Dupuy F.P, Isnard S, Goulet J-P, Lesage S, , Ghali M.P, Angel J, Chomont N, Routy J-P, Ancuta P. EBioMedicine.
March 2021
February 24 2021
February 15 2021
Peculiar Phenotypic and Cytotoxic Features of Pulmonary Mucosal CD8 T Cells in People Living with HIV Receiving Long-Term Antiretroviral Therapy
December 14 2020
HIV Infection and Persistence in Pulmonary Mucosal Double Negative T Cells In Vivo
November 23 2020
Early Antiretroviral Therapy Prevents Viral Infection of Monocytes and Inflammation in Simian Immunodeficiency Virus-Infected Rhesus Macaques
October 27 2020
Pharmacological Inhibition of PPARy Boosts HIV Reactivation and Th17 Effector Functions, While Preventing Progeny Virion Release and de novo Infection
September 30 2020
Interleukin-1β Triggers p53-Mediated Downmodulation of CCR5 and HIV-1 Entry in Macrophages through MicroRNAs 103 and 107
September 29 2020
HIV enters deep sleep in people who naturally control the virus
September 2020
Distinct viral reservoirs in individuals with spontaneous control of HIV-1
September 2020
Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont N, Bar KJ, Yu XG, Lichterfeld M, Alcami J, Hazuda D, Bushman F, Siliciano JD, Betts MR,Spivak AM, Planelles V, Hahn BH, Smith DM, Ho Y, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJ, Kostman J, Mounzer K, Caskey M, Fox L, Frank I,Riley JL, Tebas P, Montaner LJ. Nature Med.
September 7, 2020
Recommendations for measuring HIV reservoir size in cure-directed clinical trials
Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont N, Bar KJ, Yu XG, Lichterfeld M, Alcami J, Hazuda D, Bushman F, Siliciano JD, Betts MR,Spivak AM, Planelles V, Hahn BH, Smith DM, Ho Y, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJ, Kostman J, Mounzer K, Caskey M, Fox L, Frank I,Riley JL, Tebas P, Montaner LJ. Nature Med.
HIV-Captured DCs Regulate T Cell Migration and Cell-Cell Contact Dynamics to Enhance Viral Spread.
Hon Koh W, Lopez P, Ajibola O, Parvarchian R, Mohammad U, Hnatiuk R, Kindrachuk J, Murooka TT. iScienc.
August 21, 2020
Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART
Gantner P, Pagliuzza A, Pardons M, Ramgopal M, Routy JP, Fromentin R and Chomont N. Nature Communications
August 14, 2020
May 15, 2020
Improving HIV Outgrowth by Optimizing Cell-Culture Conditions and Supplementing With all-trans Retinoic Acid.
Zhang Y, Planas D, Marchand LR, Massanella M, Chen H, Wacleche VS, Gosselin A, Goulet J-P, Filion M, Routy J-P, Chomont N and Ancuta P. Frontiers in Microbiology
The Bacterium Akkermansia muciniphila: A Sentinel for Gut Permeability and Its Relevance to HIV-Related Inflammation.
Ouyang J, Lin J, Isnard S, Fombuena B, Peng X, Marette A, Routy B, Messaoudene M, Chen Y, Routy J-P. Frontiers in Immunology.
April 9, 2020
The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies.
Cohn LB, Chomont N, Deeks SG. Cell Host Microbe.
April 8, 2020
Metformin effect on gut microbiota: insights for HIV-related inflammation
Ouyang J, Isnard S, Lin J, Fombuena B, Marette A, Routy B, Chen Y, Routy JP. AIDS research and Therapy.
March 10, 2020
Plasma Levels of C-Type Lectin REG3α and Gut Damage in People With Human Immunodeficiency Virus
January 1, 2020
Despite early antiretroviral therapy effector memory and follicular helper CD4 T cells are major reservoirs in visceral lymphoid tissues of SIV-infected macaques.
November 14th, 2019
Differential Dynamics of Regulatory T-Cell and Th17 Cell Balance in Mesenteric Lymph Nodes and Blood following Early Antiretroviral Initiation during Acute Simian Immunodeficiency Virus Infection.
Yero A, Farnos O, Rabezanahary H, Racine G, Estaquier J, Jenabian MA. J. Virology
September 12th, 2019
HIV Infection Stabilizes Macrophage-T Cell Interactions To Promote Cell-Cell HIV Spread.
Lopez P, Koh WH, Hnatiuk R, Murooka TT. J. Virology
August 28th, 2019
HIV diversity and genetic compartmentalization in blood and testes during suppressive antiretroviral therapy.
Miller RL, Ponte R, Jones BR, Kinloch NN, Omondi FH, Jenabian MA, Dupuy FP, Fromentin R, Brassard P, Mehraj V, Chomont N, Poon AFY, Joy JB, Brumme Z, Routy JP; ORCHID study group. J. Virology
June 12th, 2019
Expression of MDM2 in Macrophages Promotes the Early Postentry Steps of HIV-1 Infection through Inhibition of p53.
March 21st, 2019
Breton Y, Desrosiers V, Ouellet M, Deshiere A, Torresilla C, Cohen ÉA, Tremblay MJ. J. Virology
HIV-1 is rarely detected in blood and colon myeloid cells during viral-suppressive antiretroviral therapy.
March 11th, 2019
Cattin A, Salinas TRW, Gosselin A, Planas D, Shacklett B, Cohen ÉA, Ghali MP, Routy JP, Ancuta P. AIDS
Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection.
February 27th, 2019
Pardons M, Baxter AE, Massanella M, Pagliuzza A, Fromentin R, Dufour C, Leyre L, Routy JP, Kaufmann DE, Chomont N. PLoS Pathogen.
PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals.
February 18th, 2019
Fromentin R, DaFonseca S, Costiniuk CT, El-Far M, Procopio FA, Hecht FM, Hoh R, Deeks SG, Hazuda DJ6, Lewin SR, Routy JP, Sékaly RP, Chomont N. Nature Communications.
Genetic complexity in the replication-competent latent HIV reservoir increases with untreated infection duration in infected youth.
February 1st, 2019
Medical Assistance in Death as a Unique Opportunity to Advance HIV Cure Research.
January 31rst, 2019
HIV-1 Balances the Fitness Costs and Benefits of Disrupting the Host Cell Actin Cytoskeleton Early after Mucosal Transmission.
January 9th, 2019
HIV subtype and Nef-mediated immune evasion function correlate with viral reservoir size in early-treated individuals.
January 2nd, 2019
Omondi FH, Chandrarathna S, Mujib S, Brumme CJ, Jin SW, Sudderuddin H, Miller R, Rahimi A, Laeyendecker O, Bonner P, Yue FY, Benko E, Kovacs CM, Brockman MA, Ostrowski M, Brumme ZL. J. Virology
Implications of HIV-1 Nef for "Shock and Kill" Strategies to Eliminate Latent Viral Reservoirs.
November 30th, 2018
Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants
November 27th, 2018
Phylogenetic approach to recover integration dates of latent HIV sequences within-host
September 5th, 2018
Bradley R. Jones, Natalie N. Kinloch, Joshua Horacsek, Bruce Ganase, Marianne Harris, P. Richard Harrigan, R. Brad Jones, Mark A. Brockman, Jeffrey B. Joy, Art F. Y. Poon, and Zabrina L. Brumme. PNAS
Socio-economic status and time trends associated with early ART initiation following primary HIV infection in Montreal, Canada: 1996 to 2015.
Feb 6, 2018
Mehraj V, Cox J, Lebouché B, Costiniuk C, Cao W, Li T, Ponte R, Thomas R, Szabo J, Baril JG, Trottier B, Côté P, LeBlanc R, Bruneau J, Tremblay C, Routy JP; Montreal Primary HIV-Infection Study Group. J Int AIDS Soc. 2018 Feb;21(2). doi: 10.1002/jia2.25034.
Inhibition of NF-κB-dependent HIV-1 replication by the marine natural product bengamide A.
April 15, 2018
Tietjen I, Williams DE, Read S, Kuang XT, Mwimanzi P, Wilhelm E, Markle T, Kinloch NN, Naphen CN, Tenney K, Mesplède T, Wainberg MA, Crews P, Bell B5, Andersen RJ, Brumme ZL, Brockman MA. Antiviral Res. 152:94-103. doi: 10.1016/j.antiviral.
ADAR1 and PKR, interferon stimulated genes with clashing effects on HIV-1 replication.
March 26, 2018
Radetskyy R, Daher A, Gatignol A. Cytokine Growth Factor Rev. pii: S1359-6101(18)30032-7. doi: 10.1016/j.cytogfr.2018.03.007. [Epub ahead of print]
Use of (1→3)-β-D-Glucan for diagnosis and management of invasive mycoses in HIV-infected patients.
May 31st, 2018
Farhour Z, Mehraj V, Chen J, Ramendra R, Lu H, Routy JP. Mycoses. 2018 May 31;. [Epub ahead of print]
Contrasting effect of the latency-reversing agents bryostatin-1 and JQ1 on astrocyte-mediated neuroinflammation and brain neutrophil invasion.
Dec 11, 2017
Proust A, Barat C, Leboeuf M, Drouin J, Tremblay MJ. J Neuroinflammation. 2017 Dec 11;14(1):242. doi: 10.1186/s12974-017-1019-y.
The Biology of Monocytes and Dendritic Cells: Contribution to HIV Pathogenesis.
Feb 6, 2018
Wacleche VS, Tremblay CL, Routy JP, Ancuta P. Viruses. 10(2). pii: E65. doi: 10.3390/v10020065.
Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling.
Jan 16, 2018
Wong RW, Lingwood CA, Ostrowski MA, Cabral T, Cochrane A. Sci Rep. 8(1):850. doi: 10.1038/s41598-018-19298-x.
cIAP1/2-TRAF2-SHP-1-Src-MyD88 Complex Regulates Lipopolysaccharide-Induced IL-27 Production through NF-κB Activation in Human Macrophages.
Jan 22, 2018
Busca A, Konarski Y, Gajanayaka N, O'Hara S, Angel J, Kozlowski M, Kumar A. J Immunol.pii: ji1700199. doi: 10.4049/jimmunol.1700199. [Epub ahead of print]
Inducible HIV RNA transcription assays to measure HIV persistence: pros and cons of a compromise.
Jan 17, 2018
Plantin J, Massanella M, Chomont N. Retrovirology.15(1):9. doi: 10.1186/s12977-017-0385-y.
The oncolytic virus, MG1, targets and eliminates latently HIV-1-infected cells: implications for an HIV cure.
Dec 8, 2017
Ranganath N, Sandstrom TS, Burke Schinkel SC, Côté SC, Angel JB. The Journal of Infectious Diseases.
Xenobiotic Nuclear Receptors Pregnane X Receptor and Constitutive Androstane Receptor Regulate Antiretroviral Drug Efflux Transporters at the Blood-Testis Barrier.
December, 2017
Managing Expectations of an HIV Cure: What Should We Expect?
Nov 22, 2017
Reinhard, RJ. AIDS Res Hum Retroviruses. doi: 10.1089/AID.2017.0247. [Epub ahead of print]
HIV-1 NC-induced stress granule assembly and translation arrest are inhibited by the dsRNA binding protein Staufen1.
Nov 10, 2017
Rao S, Cinti A, Temzi A, Amorim R, You JC, Mouland AJ. HIV-1 NC-induced stress granule assembly and translation arrest are inhibited by the dsRNA binding protein Staufen1. RNA. 2017 Nov 10. pii: rna.064618.117. doi: 10.1261/rna.064618.117. [Epub ahead of print]
Very early antiretroviral therapy permits CD8 T cells to keep HIV reservoirs at bay.
Nov 5, 2017
Routy JP, Mehraj V. Ann Transl Med. 2017 Nov;5(21):434. doi: 10.21037/atm.2017.08.38.
The Interferon-induced Protein Kinase R: the base of a riboprotein scaffolding regulating the Human Immunodeficiency Virus.
Nov 2017
The Th17 Lineage: From Barrier Surfaces homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis.
Oct 19, 2017
Sue Waclech V, Landay A, Routy JP, Ancuta P. Viruses. 19;9(10). pii: E303. doi: 10.3390/v9100303.
Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain.
Oct 16, 2017
Asahchop EL, Meziane O, Mamik MK, Chan WF, Branton WG, Resch L, Gill MJ, Haddad E, Guimond JV, Wainberg MA, Baker GB, Cohen EA, Power C. Retrovirology. 16;14(1):47. doi: 10.1186/s12977-017-0370-5.
Characterization of myeloid cell populations in human testes collected after sex reassignment surgery.
Oct 11, 2017
Ponte R, Dupuy F, Brimo F, Mehraj V, Brassard P, Belanger M, Yurchenko E, Ali Jenabian M, Bernard NF, Routy JP, for the ORCHID study group. Journal of Reproductive Immunology. (2018) 16-24. doi: 10.1016/j.jri.2017.10.043
Host MicroRNAs-221 and -222 Inhibit HIV-1 Entry in Macrophages by Targeting the CD4 Viral Receptor.
Oct 3, 2017
Lodge R, Ferreira Barbosa JA, Lombard-Vadnais F, Gilmore JC, Deshiere A, Gosselin A, Wiche Salinas TR, Bego MG, Power C, Routy JP, Ancuta P, Tremblay MJ, Cohen ÉA. Cell Rep. doi: 10.1016/j.celrep.2017.09.030.
The evaluation of risk-benefit ratio for gut tissue sampling in HIV cure research.
Oct 1, 2017
The Croton megalobotrys Müll Arg. traditional medicine in HIV/AIDS management: Documentation of patient use, in vitro activation of latent HIV-1 provirus, and isolation of active phorbol esters.
Sept 29, 2017
Tietjen I, Ngwenya BN, Fotso G, Williams DE, Simonambango S, Ngadjui BT, Andersen RJ, Brockman MA, Brumme ZL,Andrae-Marobela K. J Ethnopharmacol. 29;211:267-277. doi: 10.1016/j.jep.2017.09.038. [Epub ahead of print]
Antiviral Activity of Bictegravir and Cabotegravir Against Integrase Inhibitor Resistant SIVmac239 and HIV-1.
Sept 18, 2017
Hassounah SA, Alikhani A, Oliveira M, Bharaj S, Ibanescu RI, Osman N, Xu HT, Brenner BG, Mesplède T, Wainberg MA. Antimicrob Agents Chemorther, 18 sept 2017. doi: 10.1128/AAC.01695-17. [Epub ahead of print]
RNA flow cytometric FISH for investigations into HIV immunology, vaccination and cure strategies.
Sept 12, 2017
Baxter AE, Niessl J, Morou A, Kaufmann DE. AIDS Res Ther 2017 DOI 10.1186/s12981-017-0171-x
Potential contribution of gut microbiota and systemic inflammation on HIV vaccine effectiveness and vaccine design.
Sept 12, 2017
Routy JP and Mehraj V. AIDS Res Ther 2017. DOI 10.1186/s12981-017-0164-9
Multiparametric characterization of rare HIV-infected cells using an RNA-flow FISH technique.
Sept 7, 2017
Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Massanella M, Brassard N, Alsahafi N, Routy JP, Finzi A, Chomont N,Kaufmann D. Nat Protocol. doi: 10.1038/nprot.2017.079.
Pharmacologic HIV-1 Nef blockade promotes CD8 T cell–mediated elimination of latently HIV-1–infected cells in vitro.
Sept 7, 2017
Mujib S, Saiyed A, Fadel S, Bozorgzad A, Aidarus N, Yun Yue F, Benko E, Kovacs C, Emert-Sedlak LA, Smithgall TE, Ostrowski MA. JCI Insight. DOI: 10.1172/jci.insight.93684.
HIV-1 selectively targets gut-homing CCR6+CD4+ T-cells via mTOR-dependent mechanisms.
Aug 3, 2017
Planas D, Zhang Y, Monteiro P, Goulet JP, Gosselin A, Grandvaux N, Hope TJ, Fassati A, Routy JP, Ancuta P. JCI Insight. doi: 10.1172 /jci.insight.93230.
Comprehensive cross-clade characterization of antibody-mediated recognition, complement-mediated lysis and cell-mediated cytotoxicity of HIV-1 envelope specific antibodies towards the eradication of the HIV-1 reservoir.
Jul 27, 2017
Mujib S, Liu J, Rahman AKMN, Schwartz JA, Bonner P, Yue FY, Ostrowski MA. J Virol. 27;91(16). pii: e00634-17. doi: 10.1128/JVI.00634-17. Print 2017 Aug 15.
HIV-1 enhances mTORC1 activity and repositions lysosomes to the periphery by co-opting Rag GTPase.
Jul 14 2017
Cinti A, Le Sage V, Mirev MP, Valiente-Echeverria F, Crossie C, Miron MJ, Pante N, Oliver M, Mouland AJ. Scientific Reports. 7(1):5515.
Global mapping of the macrophage-HIV-1 transcriptome reveals that productive infection induces remodeling of host cell DNA and chromatin.
Jul 12 2017
Deshiere A, Joly-Beauparlant C, Breton Y, Ouellet M, Raymond F, Lodge R, Barat C, Roy M-A, Corbeil J, Tremblay MJ. Scientific Reports. 7(1):5238.
HIV-1 and HIV-Tat inhibit LPS-induced IL-27 production in human macrophages by distinct intracellular signaling pathway.
Jul 11, 2017
Gajanayaka N, O’Hara S, Konarski Y, Fernandes J, Muthumani K, Kozlowski M, Angel JB, Kumar A. J Leukoc Biol. 2017 Sep;102(3):925-939. doi: 10.1189/jlb.4A0716-332RR. Epub 2017 Jul 11.
Impairment of the type I interferon response by HIV-1: Potential targets for HIV eradication.
Apr 24, 2017
Sandstrom TS, Ranganath N, Angel JB. Cytokine Growth Factor Rev. 37:1-16. doi: 10.1016/j.cytogfr.2017.04.004. Epub 2017 Apr 24.
Tim-3 is a marker of plasmacytoid dendritic cell dysfunction during HIV infection and is associated with the recruitment of IRF7 and p85 into lysosomes and with the submembrane displacement of TLR9.
Mar 6, 2017
Schwartz JA, Clayton KL, Mujib S, Zhang H, Rahman AK, Liu J, Yue FY, Benko E, Kovacs C, Ostrowski MA. J Immunol. 2017 Apr 15;198(8):3181-3194. doi: 10.4049/jimmunol.1601298. Epub 2017 Mar 6.
HIV-1 Vpu downmodulates ICAM-1 expression resulting in decreased killing of infected CD4+ T cells by NK cells.
Mar 29, 2017
Sugden SM, Pham TN, Cohen EA. Journal of virology, 91(8): e02442-16.
CD4 T follicular helper cells and HIV infection: Friends or enemies?
Feb 20, 2017
Moukambi F, Rodrigues V, Fortier Y, Rabezanahary H, Borde C, Krust B, Andreani G, Silvestre R, Petrovas C, Laforge M, Estaquier J. Frontiers in immunology, 8:135.
HIV persists in CCR6+CD4+ T-cells from colon and blood during antiretroviral therapy.
Jan 2, 2017
Gosselin A, Wiche Salinas TR, Planas D, Wacleche VS, Zhang Y, Fromentin R, Chomont N, Cohen EA, Shacklett B, Mehraj V, Ghali MP, Routy JP, Ancuta P. AIDS2017, 31(1): 35-48.
Ebola virus VP35 blocks stress granule assembly.
Dec 23, 2016
Le Sage V, Cinti A, McCarthy S, Amorim R, Rao S, Daino GL, Tramontano E, Branch DR, Mouland AJ. Virology. 2017 Feb;502:73-83. doi: 10.1016/j.virol.2016.12.012. Epub 2016 Dec 23.
HIV-1 latency-reversing agents prostratin and bryostatin-1 induce blood-brain barrier disruption/inflammation and modulate leukocyte adhesion/transmigration.
Dec 19, 2016
Dental C, Proust A, Ouellet M, Barat C, Tremblay MJ. J Immunol. Feb 1;198(3):1229-1241. doi: 10.4049/jimmunol.1600742. Epub 2016 Dec 19.
Immune tolerance properties of the testicular tissue as a viral sanctuary site in ART-treated HIV-infected adults.
Nov 28, 2016
Jenabian MA, Costiniuk CT, Mehraj V, Ghazawi FM, Fromentin R, Brousseau J, Brassard P, Belanger M, Ancuta P, Bendayan R,Chomont N, Routy JP; for the Orchid study group. AIDS, 30(18): 2777-2786.
Enhancing virion tethering by BST2 sensitizes productively and latently HIV-infected T cells to ADCC mediated by broadly neutralizing antibodies.
Nov 17, 2016
Pham TN, Lukhele S, Dallaire F, Perron G, Cohen EA. Scientific reports, 6: 37225.
AMPK in Pathogens.
Nov 4, 2016
Mesquita I, Moreira D, Sampaio-Marques B, Laforge M, Cordeiro-da-Silva A, Ludovico P, Estaquier J, Silvestre R. Experientia Supplementum, 107: 287-323.
Differential control of BST2 restriction and plasmacytoid dendritic cell antiviral response by antagonists encoded by HIV-1 group M and O strains.
Oct 28, 2016
Bego MG, Cong L, Mack K, Kirchhoff F, Cohen EA. Journal of virology 2016, 90(22): 10236-10246.
Type I interferon responses are impaired in latently HIV infected cells.
Sept 9, 2016
Ranganath N, Sandstrom TS, Fadel S, Cote SC, Angel JB. Retrovirology 2016, 13(1): 66.
Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals.
Aug 18, 2016
Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Charlebois R, Massanella M, Brassard N, Alsahafi N, Delgado G-G,Routy JP, Walker BD, Finzi A, Chomont N, Kaufmann DE. Cell Host Microbe. 2016 Sep 14;20(3):368-380. doi: 10.1016/j.chom.2016.07.015. Epub 2016 Aug 18.
Kynurenine Reduces Memory CD4 T-Cell Survival by Interfering with Interleukin-2 Signaling Early during HIV-1 Infection.
Aug 12, 2016
Dagenais-Lussier X, Aounallah M, Mehraj V, El-Far M, Tremblay C, Sekaly RP, Routy JP, van Grevenynghe J; for the Montreal Primary Infection Study Group. Journal of virology, 90(17): 7967-7979
Role and modulation of drug transporters in HIV-1 therapy.
May 13, 2016
Alam C, Whyte-Allman SK, Omeragic A, Bendayan R. Adv Drug Deliv Rev. Aug 1;103:121-43. doi: 10.1016/j.addr.2016.05.001. Epub 2016 May 13.
Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth
Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth
LILAC pilot study: Effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy
March 2021
Planas D, Pagliuzza A, Ponte R, Fert A, Marchand L.R, Massanella M, Gosselin A, Mehraj V, Dupuy F.P, Isnard S, Goulet J-P, Lesage S, , Ghali M.P, Angel J, Chomont N, Routy J-P, Ancuta P. EBioMedicine.
February 24 2021
February 15 2021
Peculiar Phenotypic and Cytotoxic Features of Pulmonary Mucosal CD8 T Cells in People Living with HIV Receiving Long-Term Antiretroviral Therapy
December 14 2020
HIV Infection and Persistence in Pulmonary Mucosal Double Negative T Cells In Vivo
November 23 2020
Early Antiretroviral Therapy Prevents Viral Infection of Monocytes and Inflammation in Simian Immunodeficiency Virus-Infected Rhesus Macaques
October 27 2020
Pharmacological Inhibition of PPARy Boosts HIV Reactivation and Th17 Effector Functions, While Preventing Progeny Virion Release and de novo Infection
September 30 2020
Interleukin-1β Triggers p53-Mediated Downmodulation of CCR5 and HIV-1 Entry in Macrophages through MicroRNAs 103 and 107
September 29 2020
HIV enters deep sleep in people who naturally control the virus
September 2020
Distinct viral reservoirs in individuals with spontaneous control of HIV-1
September 2020
Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont N, Bar KJ, Yu XG, Lichterfeld M, Alcami J, Hazuda D, Bushman F, Siliciano JD, Betts MR,Spivak AM, Planelles V, Hahn BH, Smith DM, Ho Y, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJ, Kostman J, Mounzer K, Caskey M, Fox L, Frank I,Riley JL, Tebas P, Montaner LJ. Nature Med.
September 7, 2020
Recommendations for measuring HIV reservoir size in cure-directed clinical trials
Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont N, Bar KJ, Yu XG, Lichterfeld M, Alcami J, Hazuda D, Bushman F, Siliciano JD, Betts MR,Spivak AM, Planelles V, Hahn BH, Smith DM, Ho Y, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJ, Kostman J, Mounzer K, Caskey M, Fox L, Frank I,Riley JL, Tebas P, Montaner LJ. Nature Med.
HIV-Captured DCs Regulate T Cell Migration and Cell-Cell Contact Dynamics to Enhance Viral Spread.
Hon Koh W, Lopez P, Ajibola O, Parvarchian R, Mohammad U, Hnatiuk R, Kindrachuk J, Murooka TT. iScienc.
August 21, 2020
Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART
Gantner P, Pagliuzza A, Pardons M, Ramgopal M, Routy JP, Fromentin R and Chomont N. Nature Communications
August 14, 2020
May 15, 2020
Improving HIV Outgrowth by Optimizing Cell-Culture Conditions and Supplementing With all-trans Retinoic Acid.
Zhang Y, Planas D, Marchand LR, Massanella M, Chen H, Wacleche VS, Gosselin A, Goulet J-P, Filion M, Routy J-P, Chomont N and Ancuta P. Frontiers in Microbiology
The Bacterium Akkermansia muciniphila: A Sentinel for Gut Permeability and Its Relevance to HIV-Related Inflammation.
Ouyang J, Lin J, Isnard S, Fombuena B, Peng X, Marette A, Routy B, Messaoudene M, Chen Y, Routy J-P. Frontiers in Immunology.
April 9, 2020
The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies.
Cohn LB, Chomont N, Deeks SG. Cell Host Microbe.
April 8, 2020
Metformin effect on gut microbiota: insights for HIV-related inflammation
Ouyang J, Isnard S, Lin J, Fombuena B, Marette A, Routy B, Chen Y, Routy JP. AIDS research and Therapy.
March 10, 2020
Plasma Levels of C-Type Lectin REG3α and Gut Damage in People With Human Immunodeficiency Virus
January 1, 2020
Despite early antiretroviral therapy effector memory and follicular helper CD4 T cells are major reservoirs in visceral lymphoid tissues of SIV-infected macaques.
November 14th, 2019
Differential Dynamics of Regulatory T-Cell and Th17 Cell Balance in Mesenteric Lymph Nodes and Blood following Early Antiretroviral Initiation during Acute Simian Immunodeficiency Virus Infection.
Yero A, Farnos O, Rabezanahary H, Racine G, Estaquier J, Jenabian MA. J. Virology
September 12th, 2019
HIV Infection Stabilizes Macrophage-T Cell Interactions To Promote Cell-Cell HIV Spread.
Lopez P, Koh WH, Hnatiuk R, Murooka TT. J. Virology
August 28th, 2019
HIV diversity and genetic compartmentalization in blood and testes during suppressive antiretroviral therapy.
Miller RL, Ponte R, Jones BR, Kinloch NN, Omondi FH, Jenabian MA, Dupuy FP, Fromentin R, Brassard P, Mehraj V, Chomont N, Poon AFY, Joy JB, Brumme Z, Routy JP; ORCHID study group. J. Virology
June 12th, 2019
Expression of MDM2 in Macrophages Promotes the Early Postentry Steps of HIV-1 Infection through Inhibition of p53.
March 21st, 2019
Breton Y, Desrosiers V, Ouellet M, Deshiere A, Torresilla C, Cohen ÉA, Tremblay MJ. J. Virology
HIV-1 is rarely detected in blood and colon myeloid cells during viral-suppressive antiretroviral therapy.
March 11th, 2019
Cattin A, Salinas TRW, Gosselin A, Planas D, Shacklett B, Cohen ÉA, Ghali MP, Routy JP, Ancuta P. AIDS
Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection.
February 27th, 2019
Pardons M, Baxter AE, Massanella M, Pagliuzza A, Fromentin R, Dufour C, Leyre L, Routy JP, Kaufmann DE, Chomont N. PLoS Pathogen.
PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals.
February 18th, 2019
Fromentin R, DaFonseca S, Costiniuk CT, El-Far M, Procopio FA, Hecht FM, Hoh R, Deeks SG, Hazuda DJ6, Lewin SR, Routy JP, Sékaly RP, Chomont N. Nature Communications.
Genetic complexity in the replication-competent latent HIV reservoir increases with untreated infection duration in infected youth.
February 1st, 2019
Medical Assistance in Death as a Unique Opportunity to Advance HIV Cure Research.
January 31rst, 2019
HIV-1 Balances the Fitness Costs and Benefits of Disrupting the Host Cell Actin Cytoskeleton Early after Mucosal Transmission.
January 9th, 2019
HIV subtype and Nef-mediated immune evasion function correlate with viral reservoir size in early-treated individuals.
January 2nd, 2019
Omondi FH, Chandrarathna S, Mujib S, Brumme CJ, Jin SW, Sudderuddin H, Miller R, Rahimi A, Laeyendecker O, Bonner P, Yue FY, Benko E, Kovacs CM, Brockman MA, Ostrowski M, Brumme ZL. J. Virology
Implications of HIV-1 Nef for "Shock and Kill" Strategies to Eliminate Latent Viral Reservoirs.
November 30th, 2018
Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants
November 27th, 2018
Phylogenetic approach to recover integration dates of latent HIV sequences within-host
September 5th, 2018
Bradley R. Jones, Natalie N. Kinloch, Joshua Horacsek, Bruce Ganase, Marianne Harris, P. Richard Harrigan, R. Brad Jones, Mark A. Brockman, Jeffrey B. Joy, Art F. Y. Poon, and Zabrina L. Brumme. PNAS
Socio-economic status and time trends associated with early ART initiation following primary HIV infection in Montreal, Canada: 1996 to 2015.
Feb 6, 2018
Mehraj V, Cox J, Lebouché B, Costiniuk C, Cao W, Li T, Ponte R, Thomas R, Szabo J, Baril JG, Trottier B, Côté P, LeBlanc R, Bruneau J, Tremblay C, Routy JP; Montreal Primary HIV-Infection Study Group. J Int AIDS Soc. 2018 Feb;21(2). doi: 10.1002/jia2.25034.
Inhibition of NF-κB-dependent HIV-1 replication by the marine natural product bengamide A.
April 15, 2018
Tietjen I, Williams DE, Read S, Kuang XT, Mwimanzi P, Wilhelm E, Markle T, Kinloch NN, Naphen CN, Tenney K, Mesplède T, Wainberg MA, Crews P, Bell B5, Andersen RJ, Brumme ZL, Brockman MA. Antiviral Res. 152:94-103. doi: 10.1016/j.antiviral.
ADAR1 and PKR, interferon stimulated genes with clashing effects on HIV-1 replication.
March 26, 2018
Radetskyy R, Daher A, Gatignol A. Cytokine Growth Factor Rev. pii: S1359-6101(18)30032-7. doi: 10.1016/j.cytogfr.2018.03.007. [Epub ahead of print]
Use of (1→3)-β-D-Glucan for diagnosis and management of invasive mycoses in HIV-infected patients.
May 31st, 2018
Farhour Z, Mehraj V, Chen J, Ramendra R, Lu H, Routy JP. Mycoses. 2018 May 31;. [Epub ahead of print]
Contrasting effect of the latency-reversing agents bryostatin-1 and JQ1 on astrocyte-mediated neuroinflammation and brain neutrophil invasion.
Dec 11, 2017
Proust A, Barat C, Leboeuf M, Drouin J, Tremblay MJ. J Neuroinflammation. 2017 Dec 11;14(1):242. doi: 10.1186/s12974-017-1019-y.
The Biology of Monocytes and Dendritic Cells: Contribution to HIV Pathogenesis.
Feb 6, 2018
Wacleche VS, Tremblay CL, Routy JP, Ancuta P. Viruses. 10(2). pii: E65. doi: 10.3390/v10020065.
Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling.
Jan 16, 2018
Wong RW, Lingwood CA, Ostrowski MA, Cabral T, Cochrane A. Sci Rep. 8(1):850. doi: 10.1038/s41598-018-19298-x.
cIAP1/2-TRAF2-SHP-1-Src-MyD88 Complex Regulates Lipopolysaccharide-Induced IL-27 Production through NF-κB Activation in Human Macrophages.
Jan 22, 2018
Busca A, Konarski Y, Gajanayaka N, O'Hara S, Angel J, Kozlowski M, Kumar A. J Immunol.pii: ji1700199. doi: 10.4049/jimmunol.1700199. [Epub ahead of print]
Inducible HIV RNA transcription assays to measure HIV persistence: pros and cons of a compromise.
Jan 17, 2018
Plantin J, Massanella M, Chomont N. Retrovirology.15(1):9. doi: 10.1186/s12977-017-0385-y.
The oncolytic virus, MG1, targets and eliminates latently HIV-1-infected cells: implications for an HIV cure.
Dec 8, 2017
Ranganath N, Sandstrom TS, Burke Schinkel SC, Côté SC, Angel JB. The Journal of Infectious Diseases.
Xenobiotic Nuclear Receptors Pregnane X Receptor and Constitutive Androstane Receptor Regulate Antiretroviral Drug Efflux Transporters at the Blood-Testis Barrier.
December, 2017
Managing Expectations of an HIV Cure: What Should We Expect?
Nov 22, 2017
Reinhard, RJ. AIDS Res Hum Retroviruses. doi: 10.1089/AID.2017.0247. [Epub ahead of print]
HIV-1 NC-induced stress granule assembly and translation arrest are inhibited by the dsRNA binding protein Staufen1.
Nov 10, 2017
Rao S, Cinti A, Temzi A, Amorim R, You JC, Mouland AJ. HIV-1 NC-induced stress granule assembly and translation arrest are inhibited by the dsRNA binding protein Staufen1. RNA. 2017 Nov 10. pii: rna.064618.117. doi: 10.1261/rna.064618.117. [Epub ahead of print]
Very early antiretroviral therapy permits CD8 T cells to keep HIV reservoirs at bay.
Nov 5, 2017
Routy JP, Mehraj V. Ann Transl Med. 2017 Nov;5(21):434. doi: 10.21037/atm.2017.08.38.
The Interferon-induced Protein Kinase R: the base of a riboprotein scaffolding regulating the Human Immunodeficiency Virus.
Nov 2017
The Th17 Lineage: From Barrier Surfaces homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis.
Oct 19, 2017
Sue Waclech V, Landay A, Routy JP, Ancuta P. Viruses. 19;9(10). pii: E303. doi: 10.3390/v9100303.
Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain.
Oct 16, 2017
Asahchop EL, Meziane O, Mamik MK, Chan WF, Branton WG, Resch L, Gill MJ, Haddad E, Guimond JV, Wainberg MA, Baker GB, Cohen EA, Power C. Retrovirology. 16;14(1):47. doi: 10.1186/s12977-017-0370-5.
Characterization of myeloid cell populations in human testes collected after sex reassignment surgery.
Oct 11, 2017
Ponte R, Dupuy F, Brimo F, Mehraj V, Brassard P, Belanger M, Yurchenko E, Ali Jenabian M, Bernard NF, Routy JP, for the ORCHID study group. Journal of Reproductive Immunology. (2018) 16-24. doi: 10.1016/j.jri.2017.10.043
Host MicroRNAs-221 and -222 Inhibit HIV-1 Entry in Macrophages by Targeting the CD4 Viral Receptor.
Oct 3, 2017
Lodge R, Ferreira Barbosa JA, Lombard-Vadnais F, Gilmore JC, Deshiere A, Gosselin A, Wiche Salinas TR, Bego MG, Power C, Routy JP, Ancuta P, Tremblay MJ, Cohen ÉA. Cell Rep. doi: 10.1016/j.celrep.2017.09.030.
The evaluation of risk-benefit ratio for gut tissue sampling in HIV cure research.
Oct 1, 2017
The Croton megalobotrys Müll Arg. traditional medicine in HIV/AIDS management: Documentation of patient use, in vitro activation of latent HIV-1 provirus, and isolation of active phorbol esters.
Sept 29, 2017
Tietjen I, Ngwenya BN, Fotso G, Williams DE, Simonambango S, Ngadjui BT, Andersen RJ, Brockman MA, Brumme ZL,Andrae-Marobela K. J Ethnopharmacol. 29;211:267-277. doi: 10.1016/j.jep.2017.09.038. [Epub ahead of print]
Antiviral Activity of Bictegravir and Cabotegravir Against Integrase Inhibitor Resistant SIVmac239 and HIV-1.
Sept 18, 2017
Hassounah SA, Alikhani A, Oliveira M, Bharaj S, Ibanescu RI, Osman N, Xu HT, Brenner BG, Mesplède T, Wainberg MA. Antimicrob Agents Chemorther, 18 sept 2017. doi: 10.1128/AAC.01695-17. [Epub ahead of print]
RNA flow cytometric FISH for investigations into HIV immunology, vaccination and cure strategies.
Sept 12, 2017
Baxter AE, Niessl J, Morou A, Kaufmann DE. AIDS Res Ther 2017 DOI 10.1186/s12981-017-0171-x
Potential contribution of gut microbiota and systemic inflammation on HIV vaccine effectiveness and vaccine design.
Sept 12, 2017
Routy JP and Mehraj V. AIDS Res Ther 2017. DOI 10.1186/s12981-017-0164-9
Multiparametric characterization of rare HIV-infected cells using an RNA-flow FISH technique.
Sept 7, 2017
Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Massanella M, Brassard N, Alsahafi N, Routy JP, Finzi A, Chomont N,Kaufmann D. Nat Protocol. doi: 10.1038/nprot.2017.079.
Pharmacologic HIV-1 Nef blockade promotes CD8 T cell–mediated elimination of latently HIV-1–infected cells in vitro.
Sept 7, 2017
Mujib S, Saiyed A, Fadel S, Bozorgzad A, Aidarus N, Yun Yue F, Benko E, Kovacs C, Emert-Sedlak LA, Smithgall TE, Ostrowski MA. JCI Insight. DOI: 10.1172/jci.insight.93684.
HIV-1 selectively targets gut-homing CCR6+CD4+ T-cells via mTOR-dependent mechanisms.
Aug 3, 2017
Planas D, Zhang Y, Monteiro P, Goulet JP, Gosselin A, Grandvaux N, Hope TJ, Fassati A, Routy JP, Ancuta P. JCI Insight. doi: 10.1172 /jci.insight.93230.
Comprehensive cross-clade characterization of antibody-mediated recognition, complement-mediated lysis and cell-mediated cytotoxicity of HIV-1 envelope specific antibodies towards the eradication of the HIV-1 reservoir.
Jul 27, 2017
Mujib S, Liu J, Rahman AKMN, Schwartz JA, Bonner P, Yue FY, Ostrowski MA. J Virol. 27;91(16). pii: e00634-17. doi: 10.1128/JVI.00634-17. Print 2017 Aug 15.
HIV-1 enhances mTORC1 activity and repositions lysosomes to the periphery by co-opting Rag GTPase.
Jul 14 2017
Cinti A, Le Sage V, Mirev MP, Valiente-Echeverria F, Crossie C, Miron MJ, Pante N, Oliver M, Mouland AJ. Scientific Reports. 7(1):5515.
Global mapping of the macrophage-HIV-1 transcriptome reveals that productive infection induces remodeling of host cell DNA and chromatin.
Jul 12 2017
Deshiere A, Joly-Beauparlant C, Breton Y, Ouellet M, Raymond F, Lodge R, Barat C, Roy M-A, Corbeil J, Tremblay MJ. Scientific Reports. 7(1):5238.
HIV-1 and HIV-Tat inhibit LPS-induced IL-27 production in human macrophages by distinct intracellular signaling pathway.
Jul 11, 2017
Gajanayaka N, O’Hara S, Konarski Y, Fernandes J, Muthumani K, Kozlowski M, Angel JB, Kumar A. J Leukoc Biol. 2017 Sep;102(3):925-939. doi: 10.1189/jlb.4A0716-332RR. Epub 2017 Jul 11.
Impairment of the type I interferon response by HIV-1: Potential targets for HIV eradication.
Apr 24, 2017
Sandstrom TS, Ranganath N, Angel JB. Cytokine Growth Factor Rev. 37:1-16. doi: 10.1016/j.cytogfr.2017.04.004. Epub 2017 Apr 24.
Tim-3 is a marker of plasmacytoid dendritic cell dysfunction during HIV infection and is associated with the recruitment of IRF7 and p85 into lysosomes and with the submembrane displacement of TLR9.
Mar 6, 2017
Schwartz JA, Clayton KL, Mujib S, Zhang H, Rahman AK, Liu J, Yue FY, Benko E, Kovacs C, Ostrowski MA. J Immunol. 2017 Apr 15;198(8):3181-3194. doi: 10.4049/jimmunol.1601298. Epub 2017 Mar 6.
HIV-1 Vpu downmodulates ICAM-1 expression resulting in decreased killing of infected CD4+ T cells by NK cells.
Mar 29, 2017
Sugden SM, Pham TN, Cohen EA. Journal of virology, 91(8): e02442-16.
CD4 T follicular helper cells and HIV infection: Friends or enemies?
Feb 20, 2017
Moukambi F, Rodrigues V, Fortier Y, Rabezanahary H, Borde C, Krust B, Andreani G, Silvestre R, Petrovas C, Laforge M, Estaquier J. Frontiers in immunology, 8:135.
HIV persists in CCR6+CD4+ T-cells from colon and blood during antiretroviral therapy.
Jan 2, 2017
Gosselin A, Wiche Salinas TR, Planas D, Wacleche VS, Zhang Y, Fromentin R, Chomont N, Cohen EA, Shacklett B, Mehraj V, Ghali MP, Routy JP, Ancuta P. AIDS2017, 31(1): 35-48.
Ebola virus VP35 blocks stress granule assembly.
Dec 23, 2016
Le Sage V, Cinti A, McCarthy S, Amorim R, Rao S, Daino GL, Tramontano E, Branch DR, Mouland AJ. Virology. 2017 Feb;502:73-83. doi: 10.1016/j.virol.2016.12.012. Epub 2016 Dec 23.
HIV-1 latency-reversing agents prostratin and bryostatin-1 induce blood-brain barrier disruption/inflammation and modulate leukocyte adhesion/transmigration.
Dec 19, 2016
Dental C, Proust A, Ouellet M, Barat C, Tremblay MJ. J Immunol. Feb 1;198(3):1229-1241. doi: 10.4049/jimmunol.1600742. Epub 2016 Dec 19.
Immune tolerance properties of the testicular tissue as a viral sanctuary site in ART-treated HIV-infected adults.
Nov 28, 2016
Jenabian MA, Costiniuk CT, Mehraj V, Ghazawi FM, Fromentin R, Brousseau J, Brassard P, Belanger M, Ancuta P, Bendayan R,Chomont N, Routy JP; for the Orchid study group. AIDS, 30(18): 2777-2786.
Enhancing virion tethering by BST2 sensitizes productively and latently HIV-infected T cells to ADCC mediated by broadly neutralizing antibodies.
Nov 17, 2016
Pham TN, Lukhele S, Dallaire F, Perron G, Cohen EA. Scientific reports, 6: 37225.
AMPK in Pathogens.
Nov 4, 2016
Mesquita I, Moreira D, Sampaio-Marques B, Laforge M, Cordeiro-da-Silva A, Ludovico P, Estaquier J, Silvestre R. Experientia Supplementum, 107: 287-323.
Differential control of BST2 restriction and plasmacytoid dendritic cell antiviral response by antagonists encoded by HIV-1 group M and O strains.
Oct 28, 2016
Bego MG, Cong L, Mack K, Kirchhoff F, Cohen EA. Journal of virology 2016, 90(22): 10236-10246.
Type I interferon responses are impaired in latently HIV infected cells.
Sept 9, 2016
Ranganath N, Sandstrom TS, Fadel S, Cote SC, Angel JB. Retrovirology 2016, 13(1): 66.
Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals.
Aug 18, 2016
Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Charlebois R, Massanella M, Brassard N, Alsahafi N, Delgado G-G,Routy JP, Walker BD, Finzi A, Chomont N, Kaufmann DE. Cell Host Microbe. 2016 Sep 14;20(3):368-380. doi: 10.1016/j.chom.2016.07.015. Epub 2016 Aug 18.
Kynurenine Reduces Memory CD4 T-Cell Survival by Interfering with Interleukin-2 Signaling Early during HIV-1 Infection.
Aug 12, 2016
Dagenais-Lussier X, Aounallah M, Mehraj V, El-Far M, Tremblay C, Sekaly RP, Routy JP, van Grevenynghe J; for the Montreal Primary Infection Study Group. Journal of virology, 90(17): 7967-7979
Role and modulation of drug transporters in HIV-1 therapy.
May 13, 2016
Alam C, Whyte-Allman SK, Omeragic A, Bendayan R. Adv Drug Deliv Rev. Aug 1;103:121-43. doi: 10.1016/j.addr.2016.05.001. Epub 2016 May 13.
LILAC pilot study: Effects of metformin on mTOR activation and HIV reservoir persistence during antiretroviral therapy
March 2021
February 24 2021
February 15 2021
Peculiar Phenotypic and Cytotoxic Features of Pulmonary Mucosal CD8 T Cells in People Living with HIV Receiving Long-Term Antiretroviral Therapy
December 14 2020
HIV Infection and Persistence in Pulmonary Mucosal Double Negative T Cells In Vivo
November 23 2020
Early Antiretroviral Therapy Prevents Viral Infection of Monocytes and Inflammation in Simian Immunodeficiency Virus-Infected Rhesus Macaques
October 27 2020
Pharmacological Inhibition of PPARy Boosts HIV Reactivation and Th17 Effector Functions, While Preventing Progeny Virion Release and de novo Infection
September 30 2020
Interleukin-1β Triggers p53-Mediated Downmodulation of CCR5 and HIV-1 Entry in Macrophages through MicroRNAs 103 and 107
September 29 2020
HIV enters deep sleep in people who naturally control the virus
September 2020
Distinct viral reservoirs in individuals with spontaneous control of HIV-1
September 2020
Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont N, Bar KJ, Yu XG, Lichterfeld M, Alcami J, Hazuda D, Bushman F, Siliciano JD, Betts MR,Spivak AM, Planelles V, Hahn BH, Smith DM, Ho Y, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJ, Kostman J, Mounzer K, Caskey M, Fox L, Frank I,Riley JL, Tebas P, Montaner LJ. Nature Med.
Recommendations for measuring HIV reservoir size in cure-directed clinical trials
September 7, 2020
Abdel-Mohsen M, Richman D, Siliciano RF, Nussenzweig MC, Howell BJ, Martinez-Picado J, Chomont N, Bar KJ, Yu XG, Lichterfeld M, Alcami J, Hazuda D, Bushman F, Siliciano JD, Betts MR,Spivak AM, Planelles V, Hahn BH, Smith DM, Ho Y, Buzon MJ, Gaebler C, Paiardini M, Li Q, Estes JD, Hope TJ, Kostman J, Mounzer K, Caskey M, Fox L, Frank I,Riley JL, Tebas P, Montaner LJ. Nature Med.
HIV-Captured DCs Regulate T Cell Migration and Cell-Cell Contact Dynamics to Enhance Viral Spread.
August 21, 2020
Hon Koh W, Lopez P, Ajibola O, Parvarchian R, Mohammad U, Hnatiuk R, Kindrachuk J, Murooka TT. iScienc.
Single-cell TCR sequencing reveals phenotypically diverse clonally expanded cells harboring inducible HIV proviruses during ART
August 14, 2020
Gantner P, Pagliuzza A, Pardons M, Ramgopal M, Routy JP, Fromentin R and Chomont N. Nature Communications
Improving HIV Outgrowth by Optimizing Cell-Culture Conditions and Supplementing With all-trans Retinoic Acid.
May 15, 2020
Zhang Y, Planas D, Marchand LR, Massanella M, Chen H, Wacleche VS, Gosselin A, Goulet J-P, Filion M, Routy J-P, Chomont N and Ancuta P. Frontiers in Microbiology
The Bacterium Akkermansia muciniphila: A Sentinel for Gut Permeability and Its Relevance to HIV-Related Inflammation.
April 9, 2020
Ouyang J, Lin J, Isnard S, Fombuena B, Peng X, Marette A, Routy B, Messaoudene M, Chen Y, Routy J-P. Frontiers in Immunology.
The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies.
April 8, 2020
Cohn LB, Chomont N, Deeks SG. Cell Host Microbe.
Metformin effect on gut microbiota: insights for HIV-related inflammation
Ouyang J, Isnard S, Lin J, Fombuena B, Marette A, Routy B, Chen Y, Routy JP. AIDS research and Therapy.
March 10, 2020
Plasma Levels of C-Type Lectin REG3α and Gut Damage in People With Human Immunodeficiency Virus
January 1, 2020
Despite early antiretroviral therapy effector memory and follicular helper CD4 T cells are major reservoirs in visceral lymphoid tissues of SIV-infected macaques.
November 14th, 2019
Differential Dynamics of Regulatory T-Cell and Th17 Cell Balance in Mesenteric Lymph Nodes and Blood following Early Antiretroviral Initiation during Acute Simian Immunodeficiency Virus Infection.
Yero A, Farnos O, Rabezanahary H, Racine G, Estaquier J, Jenabian MA. J. Virology
September 12th, 2019
HIV Infection Stabilizes Macrophage-T Cell Interactions To Promote Cell-Cell HIV Spread.
Lopez P, Koh WH, Hnatiuk R, Murooka TT. J. Virology
August 28th, 2019
HIV diversity and genetic compartmentalization in blood and testes during suppressive antiretroviral therapy.
Miller RL, Ponte R, Jones BR, Kinloch NN, Omondi FH, Jenabian MA, Dupuy FP, Fromentin R, Brassard P, Mehraj V, Chomont N, Poon AFY, Joy JB, Brumme Z, Routy JP; ORCHID study group. J. Virology
June 12th, 2019
Expression of MDM2 in Macrophages Promotes the Early Postentry Steps of HIV-1 Infection through Inhibition of p53.
March 21st, 2019
Breton Y, Desrosiers V, Ouellet M, Deshiere A, Torresilla C, Cohen ÉA, Tremblay MJ. J. Virology
HIV-1 is rarely detected in blood and colon myeloid cells during viral-suppressive antiretroviral therapy.
March 11th, 2019
Cattin A, Salinas TRW, Gosselin A, Planas D, Shacklett B, Cohen ÉA, Ghali MP, Routy JP, Ancuta P. AIDS
Single-cell characterization and quantification of translation-competent viral reservoirs in treated and untreated HIV infection.
February 27th, 2019
Pardons M, Baxter AE, Massanella M, Pagliuzza A, Fromentin R, Dufour C, Leyre L, Routy JP, Kaufmann DE, Chomont N. PLoS Pathogen.
PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals.
February 18th, 2019
Fromentin R, DaFonseca S, Costiniuk CT, El-Far M, Procopio FA, Hecht FM, Hoh R, Deeks SG, Hazuda DJ6, Lewin SR, Routy JP, Sékaly RP, Chomont N. Nature Communications.
Genetic complexity in the replication-competent latent HIV reservoir increases with untreated infection duration in infected youth.
February 1st, 2019
Medical Assistance in Death as a Unique Opportunity to Advance HIV Cure Research.
January 31rst, 2019
HIV-1 Balances the Fitness Costs and Benefits of Disrupting the Host Cell Actin Cytoskeleton Early after Mucosal Transmission.
January 9th, 2019
HIV subtype and Nef-mediated immune evasion function correlate with viral reservoir size in early-treated individuals.
January 2nd, 2019
Omondi FH, Chandrarathna S, Mujib S, Brumme CJ, Jin SW, Sudderuddin H, Miller R, Rahimi A, Laeyendecker O, Bonner P, Yue FY, Benko E, Kovacs CM, Brockman MA, Ostrowski M, Brumme ZL. J. Virology
Implications of HIV-1 Nef for "Shock and Kill" Strategies to Eliminate Latent Viral Reservoirs.
November 30th, 2018
Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants
November 27th, 2018
Phylogenetic approach to recover integration dates of latent HIV sequences within-host
September 5th, 2018
Bradley R. Jones, Natalie N. Kinloch, Joshua Horacsek, Bruce Ganase, Marianne Harris, P. Richard Harrigan, R. Brad Jones, Mark A. Brockman, Jeffrey B. Joy, Art F. Y. Poon, and Zabrina L. Brumme. PNAS
Socio-economic status and time trends associated with early ART initiation following primary HIV infection in Montreal, Canada: 1996 to 2015.
Feb 6, 2018
Mehraj V, Cox J, Lebouché B, Costiniuk C, Cao W, Li T, Ponte R, Thomas R, Szabo J, Baril JG, Trottier B, Côté P, LeBlanc R, Bruneau J, Tremblay C, Routy JP; Montreal Primary HIV-Infection Study Group. J Int AIDS Soc. 2018 Feb;21(2). doi: 10.1002/jia2.25034.
Inhibition of NF-κB-dependent HIV-1 replication by the marine natural product bengamide A.
April 15, 2018
Tietjen I, Williams DE, Read S, Kuang XT, Mwimanzi P, Wilhelm E, Markle T, Kinloch NN, Naphen CN, Tenney K, Mesplède T, Wainberg MA, Crews P, Bell B5, Andersen RJ, Brumme ZL, Brockman MA. Antiviral Res. 152:94-103. doi: 10.1016/j.antiviral.
ADAR1 and PKR, interferon stimulated genes with clashing effects on HIV-1 replication.
March 26, 2018
Radetskyy R, Daher A, Gatignol A. Cytokine Growth Factor Rev. pii: S1359-6101(18)30032-7. doi: 10.1016/j.cytogfr.2018.03.007. [Epub ahead of print]
Use of (1→3)-β-D-Glucan for diagnosis and management of invasive mycoses in HIV-infected patients.
May 31st, 2018
Farhour Z, Mehraj V, Chen J, Ramendra R, Lu H, Routy JP. Mycoses. 2018 May 31;. [Epub ahead of print]
Contrasting effect of the latency-reversing agents bryostatin-1 and JQ1 on astrocyte-mediated neuroinflammation and brain neutrophil invasion.
Dec 11, 2017
Proust A, Barat C, Leboeuf M, Drouin J, Tremblay MJ. J Neuroinflammation. 2017 Dec 11;14(1):242. doi: 10.1186/s12974-017-1019-y.
The Biology of Monocytes and Dendritic Cells: Contribution to HIV Pathogenesis.
Feb 6, 2018
Wacleche VS, Tremblay CL, Routy JP, Ancuta P. Viruses. 10(2). pii: E65. doi: 10.3390/v10020065.
Cardiac glycoside/aglycones inhibit HIV-1 gene expression by a mechanism requiring MEK1/2-ERK1/2 signaling.
Jan 16, 2018
Wong RW, Lingwood CA, Ostrowski MA, Cabral T, Cochrane A. Sci Rep. 8(1):850. doi: 10.1038/s41598-018-19298-x.
cIAP1/2-TRAF2-SHP-1-Src-MyD88 Complex Regulates Lipopolysaccharide-Induced IL-27 Production through NF-κB Activation in Human Macrophages.
Jan 22, 2018
Busca A, Konarski Y, Gajanayaka N, O'Hara S, Angel J, Kozlowski M, Kumar A. J Immunol.pii: ji1700199. doi: 10.4049/jimmunol.1700199. [Epub ahead of print]
Inducible HIV RNA transcription assays to measure HIV persistence: pros and cons of a compromise.
Jan 17, 2018
Plantin J, Massanella M, Chomont N. Retrovirology.15(1):9. doi: 10.1186/s12977-017-0385-y.
The oncolytic virus, MG1, targets and eliminates latently HIV-1-infected cells: implications for an HIV cure.
Dec 8, 2017
Ranganath N, Sandstrom TS, Burke Schinkel SC, Côté SC, Angel JB. The Journal of Infectious Diseases.
Xenobiotic Nuclear Receptors Pregnane X Receptor and Constitutive Androstane Receptor Regulate Antiretroviral Drug Efflux Transporters at the Blood-Testis Barrier.
December, 2017
Managing Expectations of an HIV Cure: What Should We Expect?
Nov 22, 2017
Reinhard, RJ. AIDS Res Hum Retroviruses. doi: 10.1089/AID.2017.0247. [Epub ahead of print]
HIV-1 NC-induced stress granule assembly and translation arrest are inhibited by the dsRNA binding protein Staufen1.
Nov 10, 2017
Rao S, Cinti A, Temzi A, Amorim R, You JC, Mouland AJ. HIV-1 NC-induced stress granule assembly and translation arrest are inhibited by the dsRNA binding protein Staufen1. RNA. 2017 Nov 10. pii: rna.064618.117. doi: 10.1261/rna.064618.117. [Epub ahead of print]
Very early antiretroviral therapy permits CD8 T cells to keep HIV reservoirs at bay.
Nov 5, 2017
Routy JP, Mehraj V. Ann Transl Med. 2017 Nov;5(21):434. doi: 10.21037/atm.2017.08.38.
The Interferon-induced Protein Kinase R: the base of a riboprotein scaffolding regulating the Human Immunodeficiency Virus.
Nov 2017
The Th17 Lineage: From Barrier Surfaces homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis.
Oct 19, 2017
Sue Waclech V, Landay A, Routy JP, Ancuta P. Viruses. 19;9(10). pii: E303. doi: 10.3390/v9100303.
Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain.
Oct 16, 2017
Asahchop EL, Meziane O, Mamik MK, Chan WF, Branton WG, Resch L, Gill MJ, Haddad E, Guimond JV, Wainberg MA, Baker GB, Cohen EA, Power C. Retrovirology. 16;14(1):47. doi: 10.1186/s12977-017-0370-5.
Characterization of myeloid cell populations in human testes collected after sex reassignment surgery.
Oct 11, 2017
Ponte R, Dupuy F, Brimo F, Mehraj V, Brassard P, Belanger M, Yurchenko E, Ali Jenabian M, Bernard NF, Routy JP, for the ORCHID study group. Journal of Reproductive Immunology. (2018) 16-24. doi: 10.1016/j.jri.2017.10.043
Host MicroRNAs-221 and -222 Inhibit HIV-1 Entry in Macrophages by Targeting the CD4 Viral Receptor.
Oct 3, 2017
Lodge R, Ferreira Barbosa JA, Lombard-Vadnais F, Gilmore JC, Deshiere A, Gosselin A, Wiche Salinas TR, Bego MG, Power C, Routy JP, Ancuta P, Tremblay MJ, Cohen ÉA. Cell Rep. doi: 10.1016/j.celrep.2017.09.030.
The evaluation of risk-benefit ratio for gut tissue sampling in HIV cure research.
Oct 1, 2017
The Croton megalobotrys Müll Arg. traditional medicine in HIV/AIDS management: Documentation of patient use, in vitro activation of latent HIV-1 provirus, and isolation of active phorbol esters.
Sept 29, 2017
Tietjen I, Ngwenya BN, Fotso G, Williams DE, Simonambango S, Ngadjui BT, Andersen RJ, Brockman MA, Brumme ZL,Andrae-Marobela K. J Ethnopharmacol. 29;211:267-277. doi: 10.1016/j.jep.2017.09.038. [Epub ahead of print]
Antiviral Activity of Bictegravir and Cabotegravir Against Integrase Inhibitor Resistant SIVmac239 and HIV-1.
Sept 18, 2017
Hassounah SA, Alikhani A, Oliveira M, Bharaj S, Ibanescu RI, Osman N, Xu HT, Brenner BG, Mesplède T, Wainberg MA. Antimicrob Agents Chemorther, 18 sept 2017. doi: 10.1128/AAC.01695-17. [Epub ahead of print]
RNA flow cytometric FISH for investigations into HIV immunology, vaccination and cure strategies.
Sept 12, 2017
Baxter AE, Niessl J, Morou A, Kaufmann DE. AIDS Res Ther 2017 DOI 10.1186/s12981-017-0171-x
Potential contribution of gut microbiota and systemic inflammation on HIV vaccine effectiveness and vaccine design.
Sept 12, 2017
Routy JP and Mehraj V. AIDS Res Ther 2017. DOI 10.1186/s12981-017-0164-9
Multiparametric characterization of rare HIV-infected cells using an RNA-flow FISH technique.
Sept 7, 2017
Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Massanella M, Brassard N, Alsahafi N, Routy JP, Finzi A, Chomont N,Kaufmann D. Nat Protocol. doi: 10.1038/nprot.2017.079.
Pharmacologic HIV-1 Nef blockade promotes CD8 T cell–mediated elimination of latently HIV-1–infected cells in vitro.
Sept 7, 2017
Mujib S, Saiyed A, Fadel S, Bozorgzad A, Aidarus N, Yun Yue F, Benko E, Kovacs C, Emert-Sedlak LA, Smithgall TE, Ostrowski MA. JCI Insight. DOI: 10.1172/jci.insight.93684.
HIV-1 selectively targets gut-homing CCR6+CD4+ T-cells via mTOR-dependent mechanisms.
Aug 3, 2017
Planas D, Zhang Y, Monteiro P, Goulet JP, Gosselin A, Grandvaux N, Hope TJ, Fassati A, Routy JP, Ancuta P. JCI Insight. doi: 10.1172 /jci.insight.93230.
Comprehensive cross-clade characterization of antibody-mediated recognition, complement-mediated lysis and cell-mediated cytotoxicity of HIV-1 envelope specific antibodies towards the eradication of the HIV-1 reservoir.
Jul 27, 2017
Mujib S, Liu J, Rahman AKMN, Schwartz JA, Bonner P, Yue FY, Ostrowski MA. J Virol. 27;91(16). pii: e00634-17. doi: 10.1128/JVI.00634-17. Print 2017 Aug 15.
HIV-1 enhances mTORC1 activity and repositions lysosomes to the periphery by co-opting Rag GTPase.
Jul 14 2017
Cinti A, Le Sage V, Mirev MP, Valiente-Echeverria F, Crossie C, Miron MJ, Pante N, Oliver M, Mouland AJ. Scientific Reports. 7(1):5515.
Global mapping of the macrophage-HIV-1 transcriptome reveals that productive infection induces remodeling of host cell DNA and chromatin.
Jul 12 2017
Deshiere A, Joly-Beauparlant C, Breton Y, Ouellet M, Raymond F, Lodge R, Barat C, Roy M-A, Corbeil J, Tremblay MJ. Scientific Reports. 7(1):5238.
HIV-1 and HIV-Tat inhibit LPS-induced IL-27 production in human macrophages by distinct intracellular signaling pathway.
Jul 11, 2017
Gajanayaka N, O’Hara S, Konarski Y, Fernandes J, Muthumani K, Kozlowski M, Angel JB, Kumar A. J Leukoc Biol. 2017 Sep;102(3):925-939. doi: 10.1189/jlb.4A0716-332RR. Epub 2017 Jul 11.
Impairment of the type I interferon response by HIV-1: Potential targets for HIV eradication.
Apr 24, 2017
Sandstrom TS, Ranganath N, Angel JB. Cytokine Growth Factor Rev. 37:1-16. doi: 10.1016/j.cytogfr.2017.04.004. Epub 2017 Apr 24.
Tim-3 is a marker of plasmacytoid dendritic cell dysfunction during HIV infection and is associated with the recruitment of IRF7 and p85 into lysosomes and with the submembrane displacement of TLR9.
Mar 6, 2017
Schwartz JA, Clayton KL, Mujib S, Zhang H, Rahman AK, Liu J, Yue FY, Benko E, Kovacs C, Ostrowski MA. J Immunol. 2017 Apr 15;198(8):3181-3194. doi: 10.4049/jimmunol.1601298. Epub 2017 Mar 6.
HIV-1 Vpu downmodulates ICAM-1 expression resulting in decreased killing of infected CD4+ T cells by NK cells.
Mar 29, 2017
Sugden SM, Pham TN, Cohen EA. Journal of virology, 91(8): e02442-16.
CD4 T follicular helper cells and HIV infection: Friends or enemies?
Feb 20, 2017
Moukambi F, Rodrigues V, Fortier Y, Rabezanahary H, Borde C, Krust B, Andreani G, Silvestre R, Petrovas C, Laforge M, Estaquier J. Frontiers in immunology, 8:135.
HIV persists in CCR6+CD4+ T-cells from colon and blood during antiretroviral therapy.
Jan 2, 2017
Gosselin A, Wiche Salinas TR, Planas D, Wacleche VS, Zhang Y, Fromentin R, Chomont N, Cohen EA, Shacklett B, Mehraj V, Ghali MP, Routy JP, Ancuta P. AIDS2017, 31(1): 35-48.
Ebola virus VP35 blocks stress granule assembly.
Dec 23, 2016
Le Sage V, Cinti A, McCarthy S, Amorim R, Rao S, Daino GL, Tramontano E, Branch DR, Mouland AJ. Virology. 2017 Feb;502:73-83. doi: 10.1016/j.virol.2016.12.012. Epub 2016 Dec 23.
HIV-1 latency-reversing agents prostratin and bryostatin-1 induce blood-brain barrier disruption/inflammation and modulate leukocyte adhesion/transmigration.
Dec 19, 2016
Dental C, Proust A, Ouellet M, Barat C, Tremblay MJ. J Immunol. Feb 1;198(3):1229-1241. doi: 10.4049/jimmunol.1600742. Epub 2016 Dec 19.
Immune tolerance properties of the testicular tissue as a viral sanctuary site in ART-treated HIV-infected adults.
Nov 28, 2016
Jenabian MA, Costiniuk CT, Mehraj V, Ghazawi FM, Fromentin R, Brousseau J, Brassard P, Belanger M, Ancuta P, Bendayan R,Chomont N, Routy JP; for the Orchid study group. AIDS, 30(18): 2777-2786.
Enhancing virion tethering by BST2 sensitizes productively and latently HIV-infected T cells to ADCC mediated by broadly neutralizing antibodies.
Nov 17, 2016
Pham TN, Lukhele S, Dallaire F, Perron G, Cohen EA. Scientific reports, 6: 37225.
AMPK in Pathogens.
Nov 4, 2016
Mesquita I, Moreira D, Sampaio-Marques B, Laforge M, Cordeiro-da-Silva A, Ludovico P, Estaquier J, Silvestre R. Experientia Supplementum, 107: 287-323.
Differential control of BST2 restriction and plasmacytoid dendritic cell antiviral response by antagonists encoded by HIV-1 group M and O strains.
Oct 28, 2016
Bego MG, Cong L, Mack K, Kirchhoff F, Cohen EA. Journal of virology 2016, 90(22): 10236-10246.
Type I interferon responses are impaired in latently HIV infected cells.
Sept 9, 2016
Ranganath N, Sandstrom TS, Fadel S, Cote SC, Angel JB. Retrovirology 2016, 13(1): 66.
Single-Cell Characterization of Viral Translation-Competent Reservoirs in HIV-Infected Individuals.
Aug 18, 2016
Baxter AE, Niessl J, Fromentin R, Richard J, Porichis F, Charlebois R, Massanella M, Brassard N, Alsahafi N, Delgado G-G,Routy JP, Walker BD, Finzi A, Chomont N, Kaufmann DE. Cell Host Microbe. 2016 Sep 14;20(3):368-380. doi: 10.1016/j.chom.2016.07.015. Epub 2016 Aug 18.
Kynurenine Reduces Memory CD4 T-Cell Survival by Interfering with Interleukin-2 Signaling Early during HIV-1 Infection.
Aug 12, 2016
Dagenais-Lussier X, Aounallah M, Mehraj V, El-Far M, Tremblay C, Sekaly RP, Routy JP, van Grevenynghe J; for the Montreal Primary Infection Study Group. Journal of virology, 90(17): 7967-7979
Role and modulation of drug transporters in HIV-1 therapy.
May 13, 2016
Alam C, Whyte-Allman SK, Omeragic A, Bendayan R. Adv Drug Deliv Rev. Aug 1;103:121-43. doi: 10.1016/j.addr.2016.05.001. Epub 2016 May 13.
Role of P-glycoprotein in the distribution of the HIV protease inhibitor atazanavir in the brain and male genital tract.
Dec 30, 2013
Robillard KR, Chan GN, Zhang G, la Porte C, Cameron W, Bendayan R. Antimicrobial agents and chemotherapy, 58(3): 1713-1722.
Control of dendritic cell migration, T cell-dependent immunity, and autoimmunity by protein tyrosine phosphatase PTPN12 expressed in dendritic cells.
Dec 23, 2013
Rhee I, Zhong MC, Reizis B, Cheong C, Veillette A. Molecular and cellular biology 2014, 34(5): 888-899.
From arrest to escape: HIV-1 Vpr cuts a deal.
Feb 12, 2014
Cohen EA. Cell host & microbe 2014, 15(2): 125-127
HIV Nef and Vpu protect HIV-infected CD4+ T cells from antibody-mediated cell lysis through down-modulation of CD4 and BST2.
Feb 6, 2014
Pham TN, Lukhele S, Hajjar F, Routy JP, Cohen EA. Retrovirology 2014, 11: 15
Deamination intensity profiling of human APOBEC3 protein activity along the near full-length genomes of HIV-1 and MoMLV by HyperHRM analysis.
Jan 4, 2014
Belanger K, Savoie M, Aydin H, Renner TM, Montazeri Z, Langlois MA. Virology 2014, 448: 168-175.
Transcriptional profiling reveals molecular signatures associated with HIV permissiveness in Th1Th17 cells and identifies peroxisome proliferator-activated receptor gamma as an intrinsic negative regulator of viral replication.
Dec 21, 2013
Selective recognition of viral promoters by host cell transcription complexes: challenges and opportunities to control latency.
Jul 1, 2013
Wilhelm E, Bell B. Current opinion in virology 2013, 3(4): 380-386
Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells.
Jun 14, 2013
Youngblood B, Noto A, Porichis F, Akondy RS, Ndhlovu ZM, Austin JW, Bordi R, Procopio FA, Miura T, Allen TM, Sidney J, Sette A, Walker BD, Ahmed R, Boss JM, Sekaly RP, Kaufmann DE. Journal of immunology 2013, 191(2): 540-544.
Interleukin-7 promotes HIV persistence during antiretroviral therapy.
Apr 15, 2013
Vandergeeten C, Fromentin R, DaFonseca S, Lawani MB, Sereti I, Lederman MM, Ramgopal M, Routy JP, Sekaly RP, Chomont N. Blood 2013, 121(21): 4321-4329.
Role of drug efflux and uptake transporters in atazanavir intestinal permeability and drug-drug interactions.
Dec 7, 2012
Kis O, Zastre JA, Hoque MT, Walmsley SL, Bendayan R. Pharmaceutical research 2013, 30(4): 1050-1064.
High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control.
Dec 11, 2012
Ndhlovu ZM, Chibnik LB, Proudfoot J, Vine S, McMullen A, Cesa K, Porichis F, Jones RB, Alvino DM, Hart MG, Stampouloglou E, Piechocka-Trocha A, Kadie C, Pereyra F, Heckerman D, De Jager PL, Walker BD, Kaufmann DE. Blood 2013, 121(5): 801-811.
Modulation of HIV reservoirs by host HLA: bridging the gap between vaccine and cure.
Aug 29, 2012
Brumme ZL, Chopera DR, Brockman MA. Current opinion in virology 2012, 2(5): 599-605.
Differential HIV-1 endocytosis and susceptibility to virus infection in human macrophages correlate with cell activation status.
Jul 11, 2012
Gobeil LA, Lodge R, Tremblay MJ. Journal of virology 2012, 86(19): 10399-10407.
Exon level transcriptomic profiling of HIV-1-infected CD4(+) T cells reveals virus-induced genes and host environment favorable for viral replication.
Aug 2, 2012
Imbeault M, Giguere K, Ouellet M, Tremblay MJ. PLoS pathogens 2012, 8(8): e1002861.
CTGC motifs within the HIV core promoter specify Tat-responsive pre-initiation complexes.
Jul 26, 2012
Wilhelm E, Doyle MC, Nzaramba I, Magdzinski A, Dumais N, Bell B. Retrovirology, 9: 62.
Towards an HIV cure: a global scientific strategy.
Jul 20, 2012
The International AIDS Society Scientific Working Group on HIV Cure: Deeks SG, Autran B, Berkhout B, Benkirane M, Cairns S, Chomont N, Chun TW, Churchill M, Di Mascio M, Katlama C, Lafeuillade A, Landay A, Lederman M, Lewin SR, Maldarelli F, Margolis D, Markowitz M, Martinez-Picado J, Mullins JI, Mellors J, Moreno S, O'Doherty U, Palmer S, Penicaud MC, Peterlin M, Poli G, Routy JP, Rouzioux C, Silvestri G, Stevenson M, Telenti A, Van Lint C, Verdin E, Woolfrey A, Zaia J, Barre-Sinoussi F. Nature reviews immunology, 12(8): 607-614.